Aging Auditory System: Presbycusis and Its Neural Bases - Supplement

翻译后摘要：本补充，以促进多样性的目的是提供博士前， 研究生对Jennifer Pineros女士，M.S.，一位西班牙裔女性生物医学专家 工程师.生物医学研究、生物医学工程和老龄化研究的多样性将得到加强。 在这个项目中提供了几种方式，包括增加西班牙裔的数量， 拉丁美洲人参与生物医学研究和开发，以及增加的数量， 从事工程和老龄化研究的女性。女性仍然处于高度- 在工程等STEM领域有代表性。Pineros女士，在要求的两年期间， 补充资金期间，将开展严谨、多方面、跨学科的 一项教育研究计划，重点是加快具体目标之一的进展 我们目前的NIA计划项目赠款（P01 AG 009524 -23），集中在发现一些 年龄相关性听力损失的神经基础和分子机制，以及对 药物发现，以防止或减缓这种高度流行的感觉障碍，涉及感觉 系统和老化的神经系统。Pineros女士的博士项目将集中在目前的P01 我们的动物模型项目的具体目标1，重点是项目4。同志顺应 国家衰老研究所的使命，我们的实验目标是探索正常的衰老过程， 和年龄相关的听力损失（ARHL）机制，因为这些往往是加速或 由于常见的衰老医学状况而加剧，例如荷尔蒙失衡， 下降。具体来说，Pineros女士将研究神经和分子基础， 加速的与年龄相关的听力损失特征的可能可逆性 衰老的条件;包括激素缺乏，不平衡和治疗效果 与ARHL相关-老年性耳聋。这些实验是在一个 多学科的方式，包括调查听力和听觉生理学的变化， 解剖学改变和分子生物标志物变化与激素失衡， 激素药物补充剂在老龄动物。教学培训和增值教育 本补充材料的组成部分包括定期的导师会议，有针对性的正式课程， 每周项目会议，每月计划项目会议，研究研讨会， 生物工程，老龄化，并在医学院，并介绍了在国家和 国际研究会议（ARO，IEEE，BMES，Soc. Neuroscience.），导致同行- 审查出版物并完成生物医学工程博士学位。

Abstract: The purpose of this Supplement to Promote Diversity is to provide Pre-Doctoral, Graduate student support for Ms. Jennifer Pineros, M.S., a Hispanic, woman biomedical engineer. Diversity in biomedical research, biomedical engineering, and aging research will be provided in this project in several ways, including increasing the number of Hispanics and Latinos involved in biomedical research and development, as well as increasing the number of women pursuing careers in engineering and aging research. Women are still highly under- represented in STEM areas such as engineering. Ms. Pineros, during the 2-year requested Supplemental funding period, will carry out a rigorous, multi-faceted, interdisciplinary educational research program focused on accelerating the progress of one of the Specific Aims of our current NIA Program Project grant (P01 AG009524-23), centering on discovering some of the neural bases and molecular mechanisms of age-related hearing loss, and implications for drug discovery, to prevent or slow down this highly prevalent sensory disorder involving sensory systems and the aging nervous system. Ms. Pineros' PhD project will focus on the current P01 Specific Aim 1 for our animal model projects, focusing upon Project 4. In keeping with the National Institute on Aging's mission, our experimental aims explore normal aging processes, and age-related hearing (ARHL) loss mechanisms, as these are oftentimes accelerated or exacerbated by common medical conditions of aging, such as hormonal imbalances and declines. Specifically, Ms. Pineros will be investigating the neural and molecular bases, and possible reversibility of the accelerated age-related hearing loss characteristic of medical conditions in aging; including hormonal deficiencies, imbalances and therapeutic effects relevant for ARHL – presbycusis. The experiments are carefully coordinated in a multidisciplinary way, including investigations of changes in hearing and auditory physiology, anatomical alterations, and molecular biomarker changes with hormonal imbalances and hormonal drug supplementation in aging animals. Didactic training and value added educational components of this Supplement include regular Mentor meetings, targeted formal coursework, weekly project meetings, monthly Program Project meetings, research seminars in bioengineering, aging, and at the medical school, and presentation of findings at national and international research meetings (ARO, IEEE, BMES, Soc. Neuroscience…), leading to peer- reviewed publications and completion of a PhD in biomedical engineering.