Synthetic Biology and Biotechnology (SB2) Predoctoral Training Program

合成生物学与生物技术（SB2）博士前培训项目

• 批准号: 10654551
• 负责人: CHRISTOPHER S CHEN
• 金额: $ 22.98万
• 依托单位: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10654551
• 关键词: Biotechnology; Training Programs; pre-doctoral; synthetic biology

Project Summary/Abstract This application seeks funding for a Biotechnology Predoctoral Training Program in Synthetic Biology at Boston University. Three predoctoral training slots per year are requested, to support trainees for their second and third years of residence. The Synthetic Biology and Biotechnology (SB2) Program aims to prepare top researchers for careers in synthetic biology. Synthetic biology uses engineering approaches to build complex biological systems for research and applications, ranging from industrial chemistry to medical breakthroughs. This fast-growing discipline has the potential to revolutionize many scientific fields and industries, including biotechnology, and our program will be the first in the nation to prepare students specifically in synthetic biology. An intrinsically interdisciplinary field, our program integrates (a) solid technical foundation in the principles and practices of synthetic biology, (b) hands-on exposure to biotech research and the principles of commercialization for translating new synthetic biology technologies, (c) and extensive professional skills development, including teamwork and communication, necessary to success in interdisciplinary teams. The curriculum includes a strong didactic foundation in molecular and cellular engineering, the theory and practice of synthetic biology, data analysis, and basic understanding of commercialization and industrial research goals, along with in-depth examination of a broad range of potential applications. Experiential learning is emphasized throughout the curriculum. Program features include (1) summer internship in a local biotech company, (2) Synthetic Biology Laboratory to introduce state-of-the-art techniques and data analysis methodologies, (3) rigorous dissection of literature focusing on critical thinking and experimental design and validation, (4) a 5-day intensive training course in Biotechnology Entrepreneurship, (5) an SB2 Annual Seminar and Poster Day at which trainees present their research. Emphasis is placed throughout in developing skills in reproducible and rigorous research, in communicating science, and in understanding how to apply synthetic biology to find new solutions to existing problems in academia and biotechnology. Numerous mechanisms are employed to assist trainees in preparing for diverse career paths with formal and informal opportunities to interact with scientists from a range of careers. A distinguished training faculty of 20 mentors is drawn from various departments and colleges at Boston University, with expertise in engineering, biology, chemistry, pharmacology, computer engineering, and physics. All students have a primary and secondary advisor, one focused on foundational tools and one on applications, to ensure their research is clearly motivated and far-reaching. Students play critical roles in defining their interdisciplinary research projects by developing a formal Individual Development Plan.

项目概要/摘要 本申请寻求合成生物学生物技术博士前培训计划的资助 在波士顿大学。每年需要三个博士前培训名额，以支持学员 他们居住的第二年和第三年。合成生物学和生物技术（SB2）计划 旨在为合成生物学领域的顶尖研究人员做好准备。合成生物学利用工程学 构建用于研究和应用的复杂生物系统的方法，范围从工业 化学到医学的突破。这一快速发展的学科有可能带来革命性的变革 许多科学领域和行业，包括生物技术，我们的项目将是世界上第一个 国家专门为学生准备合成生物学。本质上是一个跨学科领域，我们的 计划整合了（a）合成生物学原理和实践的坚实技术基础， (b) 亲身接触生物技术研究以及转化新产品的商业化原则 合成生物学技术，(c) 和广泛的专业技能发展，包括团队合作 和沟通，这是跨学科团队取得成功所必需的。课程包括 在分子和细胞工程、合成理论和实践方面有坚实的教学基础 生物学、数据分析以及对商业化和工业研究目标的基本了解， 以及对广泛的潜在应用的深入研究。体验式学习是 整个课程都强调。项目特色包括（1）在当地暑期实习 生物科技公司，（2）合成生物学实验室引进最先进的技术和数据 分析方法，（3）对文献进行严格的剖析，重点关注批判性思维和 实验设计和验证，(4) 为期 5 天的生物技术强化培训课程 创业精神，(5) SB2 年度研讨会和海报日，学员可以在会上展示他们的成果 研究。重点始终放在培养可重复和严谨的研究技能， 传播科学，并了解如何应用合成生物学来寻找新的解决方案 学术界和生物技术领域存在的问题。采用多种机制来协助 受训者为多样化的职业道路做好准备，并有正式和非正式的互动机会 来自不同职业的科学家。由 20 名导师组成的杰出培训师资队伍来自 波士顿大学的各个系和学院，在工程、生物学、 化学、药理学、计算机工程和物理学。所有学生都有小学和 二级顾问，一名专注于基础工具，一名专注于应用程序，以确保他们 研究显然是有动机且影响深远的。学生在定义自己的能力方面发挥着关键作用 通过制定正式的个人发展计划来开展跨学科研究项目。

项目成果

Long-term evolution of proliferating cells using the eVOLVER platform.

使用 eVOLVER 平台进行增殖细胞的长期进化。

• DOI: 10.1101/2023.03.28.534552
• 发表时间: 2023
• 期刊: bioRxiv : the preprint server for biology
• 作者: García-Ruano,Daniel;Jain,Akanksha;Heins,ZacharyJ;Wong,BrandonG;YimerWolle,Ezira;Khalil,AhmadS;Coudreuse,Damien
• 通讯作者: Coudreuse,Damien

Scaffold proteins as dynamic integrators of biological processes.

• DOI: 10.1016/j.jbc.2022.102628
• 发表时间: 2022-12
• 期刊: JOURNAL OF BIOLOGICAL CHEMISTRY
• 影响因子: 4.8
• 作者: DiRusso, Christopher J.;Dashtiahangar, Maryam;Gilmore, Thomas D.
• 通讯作者: Gilmore, Thomas D.