Outreach, Recruitment and Engagement Core

外展、招聘和参与核心

• 批准号: 10378618
• 负责人: Christine S Ritchie
• 金额: $ 21.13万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-15 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10378618
• 关键词: Affect; Alzheimer' s Disease; Alzheimer' s disease related dementia; Area; Awareness; Biology; Boston; Brain; Caring; Cities; Clinic; Clinical; Clinical Research; Clinical Trials; Communities; Community Health Education; Consultations; Cultural Diversity; Custom; Data; Databases; Dementia; Diagnosis; Diagnostic; Disease; Early Diagnosis; Education; Elderly; Electronic Mail; Enrollment; Environment; Ethnic Origin; Event; Evolution; Faculty; Fostering; Future; Genetic study; Goals; Health; Health Professional; Individual; Learning; Lewy Bodies; Marshal; Massachusetts; Memory; Memory Disorders; Methods; Minority Groups; Mission; Natural History; Needs Assessment; Neurologist; Neurology; Neuropsychology; Participant; Pharmacology; Prevention; Public Health; Rapid diagnostics; Registries; Research; Resources; Risk; Sampling; Specialist; Teacher Professional Development; Therapeutic Trials; Training; Underrepresented Minority; Underrepresented Populations; Work; base; biobank; clinical biomarkers; clinical center; cohort; community engagement; community setting; dementia care; disease heterogeneity; diversity and inclusion; ethnic diversity; innovation; medical schools; minority communities; neuroimaging marker; outreach; participant enrollment; patient advocacy group; programs; rapid technique; recruit; research study; skills; social media; socioeconomics; success; tool; volunteer; web site

Massachusetts Alzheimer’s Disease Research Center: Outreach, Recruitment and Engagement Core The Outreach, Recruitment and Engagement (ORE) Core of the Massachusetts Alzheimer’s Disease Research Center (MADRC) has shifted its focus towards early detection and prevention while concentrating on the critical need for diversity within clinical trials and research studies. This mission aligns well with MADRC’s overall goals for understanding disease heterogeneity; as diversity across education, ethnicity and socio- economic strata affects not only the biology of Alzheimer’s Disease (AD) and related dementias (ADRD) but the clinical expression of disease as well. Only as we expand and diversify participation in AD/ADRD clinical research will we acquire new strategies to find a cure. The ORE core will meet these challenges by focusing its mission in several areas: We will marshal resources to meet the recruitment and retention needs of the MADRC Clinical Core and all MADRC affiliated research studies (Aim 1). We will work with the Clinical Core to increase the clinical and demographic diversity of the Research Cohort in clinical and community settings. We will also develop liaisons with local and national groups to increase public awareness about AD/ADRD dementias, particularly within underrepresented minority groups (Aim 2) and work to increase diversity in all our research studies. We intend to collaborate with city and state agencies fostering a Dementia Friendly environment to bring education about prevention, AD/ADRD resources and clinical trial opportunities to underserved and ethnically diverse communities. We also intend to work with the Neuropath core to educate the public about the value of brain donation and the lessons learned from these studies (Aim 3). We intend to develop new strategies to facilitate rapid enrollment into clinical trials by working with the Data and Clinical cores to build and maintain a registry of research ready participants (Aim 4) who agree to be contacted as clinical and research trials become available. We will build toward the future by developing a Rapid Diagnostic Clinic to facilitate earlier diagnosis and enrollment of participants into research studies and working with the Data Core to recruit from a BioBank EHR Database that will allow rapid recruitment of large or highly customizable samples (Aim 5). We will also provide customized education and support to PCP practitioners, faith-based ministers and geriatric specialists who are on the frontlines of dementia care. We will work with the REC to train fellows in cultural diversity and community engagement (Aim 6). The ORE core interfaces with all the MADRC cores by providing education to the public about clinical, biomarker and genetic studies and the value of brain donations. It supports the recruitment needs of all the MADRC cores and affiliated research studies. Only together will we find a cure for AD/ADRD before 2025.

马萨诸塞州阿尔茨海默病研究中心：外展，招聘和参与的核心 马萨诸塞州阿尔茨海默病的外展、招募和参与（ORE）核心 研究中心（MADRC）已将重点转向早期发现和预防，同时专注于 临床试验和研究中对多样性的迫切需求。这一使命与MADRC的 理解疾病异质性的总体目标;由于教育、种族和社会的多样性， 经济阶层不仅影响阿尔茨海默病（AD）和相关痴呆症（ADRD）的生物学， 疾病的临床表现。只有当我们扩大和多样化参与AD/ADRD临床 研究将使我们获得新的治疗方法。ORE核心将通过专注于 它在几个领域的使命： 我们将调动资源，以满足MADRC临床核心和所有 MADRC附属研究（目标1）。我们将与临床核心合作， 研究队列在临床和社区环境中的人口统计学多样性。我们还将发展联络 与地方和国家团体合作，提高公众对AD/ADRD痴呆症的认识，特别是在 代表性不足的少数群体（目标2），并努力增加我们所有研究的多样性。我们打算 与城市和州机构合作，营造一个对痴呆症友好的环境， 预防、AD/ADRD资源和临床试验机会， 社区.我们还打算与神经病核心合作，教育公众大脑的价值。 这些研究的目的是为了评估捐赠和从这些研究中吸取的教训（目标3）。 我们打算开发新的策略，通过与数据合作，促进快速入组临床试验 和临床核心，以建立和维护研究准备参与者的登记（目标4），他们同意 在临床和研究试验可用时联系。 我们将通过开发快速诊断诊所来促进早期诊断， 招募参与者进入研究，并与数据核心合作，从生物银行EHR招募 数据库将允许快速招募大型或高度可定制的样本（目标5）。我们还将提供 为PCP从业人员、宗教牧师和老年病专家提供定制教育和支持， 在痴呆症治疗的第一线我们将与区域经济委员会合作，培训文化多样性方面的研究员， 社区参与（目标6）。 ORE核心通过向公众提供关于临床、医学和生物医学的教育， 生物标志物和基因研究以及大脑捐赠的价值。它支持所有的招聘需求， MADRC核心和附属研究。只有共同努力，我们才能在2025年之前找到治疗AD/ADRD的方法。