Bridging the Science-to-Service Gap in Aging Care: Prevention, Optimization and Living Well with Persistent or Serious Illnesses

缩小老年护理中科学与服务的差距：持续或严重疾病的预防、优化和健康生活

• 批准号: 10638577
• 负责人: Christine S Ritchie
• 金额: $ 17.4万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-01 至 2028-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10638577
• 关键词: Aging; Caring; Prevention; Science; service gap

PROJECT SUMMARY: Bridging the Science-to-Service Gap in Aging Care (BRIDGE THE GAP): Prevention, Optimization and Living Well with Persistent or Serious Illnesses The proposed T32 postdoctoral fellowship will address the pressing need for strengthening and diversifying the pipeline for well-trained clinician investigators positioned to advance the field of aging research through the development, testing, and implementation of clinical and behavioral preventive interventions (CBPIs) across the spectrum from health to illness across all care settings (e.g., hospital, nursing homes) and in the community for individuals and their informal caregivers. Despite advances in medical, social and behavioral sciences, a widely acknowledged science-to-service gap remains such that most interventions are rarely implemented in the routine care of older adults in clinical or community settings. This gap is particularly apparent in the care of those with Alzheimer’s Disease and related dementias (ADRD), where there is a dearth of evidence-based approaches to support persons living with dementia (PLWD) and their caregivers across the disease trajectory. A key reason for this “implementation cliff” is the lack of rigorous and comprehensive training in all stages of the NIH model for new clinical investigators that enter the field of aging. Further, to date, very little research has been focused on prevention of age-related negative consequences. We are well positioned to address this important gap because we have access to both an exceptionally talented pool of interdisciplinary trainees (PhD and MD) and an unparalleled network of interdisciplinary, NIH funded faculty mentors and investigators with complementary expertise in CBPIs in primary prevention (e.g. treating ADRD risk factors to prevent onset), secondary prevention (e.g., prevention of emotional distress in ADRD), and tertiary prevention (e.g., increasing quality of life in ADRD). Two new trainees who have recently completed their clinical training will enter the program each year and will receive a maximum of three years of support (maximum 6 trainees at one time). Trainees will receive interdisciplinary mentorship across 1) the Department of Internal Medicine Mongan Institute (including the Center for Aging and Serious Illness) 2) the Department of Psychiatry (including the Center for Health Outcomes and Interdisciplinary Research) and 3) the Department of Neurology (including the Massachusetts ADRD Research Center). Trainees will receive specialized didactic training that covers methods across the NIH stage model, trial design and community engaged research across primary, secondary and tertiary prevention, biostatistics, clinical trial management, scientific writing, health disparities and social determinants of health, leadership skills and career planning, in preparation for career development awards or other independent applications to be submitted by the end of the fellowship period. Trainees will develop mentored clinical research projects that use the NIH stage model and will receive experiential training through their mentors’ NIH funded clinical trials. Our trainees will graduate with a deep understanding of the NIH stage model, skills to develop and implement scalable and equitable preventive interventions in all care settings, and the research tools necessary to advance the science of aging and improve care for our growing older adult population.

项目摘要：弥合老化护理中的科学服务差距（桥梁差距）：预防， 优化和与持续或严重疾病一起生活 拟议的T32博士后奖学金将解决加强和多元化的迫切需求 训练有素的临床研究人员定位，可以通过开发，测试和 从健康到疾病的临床和行为预防干预措施（CBPI）的实施 所有护理环境（例如医院，护士房屋）以及社区中的个人及其非正式护理人员。尽管 医学，社会和行为科学的进步，公认的科学服务差距仍然如此，以至于大多数 在临床或社区环境中老年人的常规护理中，很少实施干预措施。这个差距是 在患有阿尔茨海默氏病和相关痴呆症（ADRD）的人的照顾下，尤其明显 基于证据的方法来支持痴呆症患者（PLWD）及其护理人员在疾病中 弹道。这种“实施悬崖”的关键原因是在各个阶段缺乏严格而全面的培训 进入衰老领域的新临床研究人员的NIH模型。此外，迄今为止，研究很少 专注于预防与年龄相关的负面后果。我们在解决这一重要差距方面有好处，因为 我们可以访问一个非常有才华的跨学科学员（PhD和MD）和无与伦比的 NIH跨学科的网络资助了CBPIS完善知识的教师和调查员 初级预防（例如，治疗ADRD风险因素以防止发作），次要预防（例如，预防情绪 ADRD的困扰）和第三级预防（例如，ADRD的生活质量提高）。两名新学员最近 完成他们的临床培训将每年进入该计划，并最多获得三年的支持 （一次最多6名）。学员将在1）内部部门接受跨学科的心态 医学蒙加研究所（包括老化和严重疾病中心）2）精神病学系（包括 健康成果与跨学科研究中心）和3）神经病学系（包括 马萨诸塞州ADRD研究中心）。学员将接受专门的教学培训 NIH舞台模型，试验设计和社区参与研究，跨初级，二级和三级预防的研究， 生物统计学，临床试验管理，科学写作，健康差异和健康的社会决定者，领导力 技能和职业计划，为提交职业发展奖或其他独立申请做准备 在团契期结束时。受训人员将开发使用NIH舞台模型的临床研究项目 并将通过其导师的NIH资助临床试验获得专家培训。我们的学员将毕业 对NIH舞台模型的深入了解，开发和实施可扩展和公平的预防干预措施的技能 在所有护理环境中 成人人口。

项目成果

The impact of a virtual mind-body program on resilience factors among international English-speaking adults with neurofibromatoses: secondary analysis of a randomized clinical trial.

虚拟身心计划对患有神经纤维瘤的国际英语成人的复原力因素的影响：随机临床试验的二次分析。

• DOI: 10.1007/s11060-023-04389-1
• 发表时间: 2023
• 期刊: Journal of neuro-oncology
• 影响因子: 3.9
• 作者: Presciutti,AlexanderM;Lester,EthanG;Woodworth,EmilyC;Greenberg,Jonathan;Bakhshaie,Jafar;Hooker,JuliaE;McDermott,KatherineA;Vranceanu,Ana-Maria
• 通讯作者: Vranceanu,Ana-Maria