Addressing the chronic pain-early cognitive decline comorbidity among older adults; The Active Brains study
解决老年人慢性疼痛-早期认知能力下降的合并症;
基本信息
- 批准号:10558586
- 负责人:
- 金额:$ 59.47万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-02-01 至 2027-01-31
- 项目状态:未结题
- 来源:
- 关键词:AddressAdherenceAlzheimer disease preventionAlzheimer&aposs disease related dementiaAlzheimer&aposs disease riskAnxietyAwarenessBehaviorBenchmarkingBrainBreathingBypassCellular PhoneClinical TrialsCognitionCognitiveConsentCoping SkillsDataData CollectionEducationEducational process of instructingElderlyEmotionalEnrollmentEthnic OriginEvidence based programEvidence based treatmentExerciseFundingGeneral HospitalsGeriatricsGoalsHealthHip region structureImpaired cognitionIndividualInfrastructureInterventionInterviewInvestigationLinkMassachusettsMeasuresMediatingMediatorMental DepressionMethodologyMethodsModelingNational Center for Complementary and Integrative HealthNeurobehavioral ManifestationsOutcomePainPain intensityPain managementParticipantPatient Self-ReportPatientsPerformancePersistent painPharmaceutical PreparationsPhysical FunctionPopulationPsychologyRaceRandomizedReactionReportingRespiratory DiaphragmScanningSingle-Blind StudyStrategic PlanningStress and CopingTechnology AssessmentTestingWalkingWristacceptability and feasibilityactigraphyactive controladverse event riskbarrier to carebattery lifeblindchronic musculoskeletal painchronic painchronic pain managementclinical predictorsclinically relevantcognitive benefitscognitive functioncognitive performancecognitive reservecomorbiditydigitaldigital monitoringdisabilityeffective interventionefficacy evaluationefficacy testingemotional functioningethnic minorityexperiencefallsfeasibility trialfitbitfollow-upfunctional improvementhigh risk populationimprovedintervention deliverymind/bodymindfulnessmonitoring devicemultidisciplinarymultimodalitynormal agingnovelpain catastrophizingpain symptomparticipant retentionpre-clinicalprimary outcomeprogramsracial minorityrecruitreinforcerresponsesecondary outcomeside effectskillsslow potentialtheoriesuptakevirtualvirtual delivery
项目摘要
PROJECT SUMMARY
Chronic pain and early cognitive decline are increasingly prevalent among older adults, bidirectionally related, and
individual risk factors for Alzheimer’s Disease and Related Dementias (ADRD). Chronic pain and cognitive
decline exacerbate each other, placing individuals on a “disability spiral” or worsened physical, emotional, and
cognitive functioning with incremental risk of ADRD. Currently there are no evidence-based treatments that successfully
address the chronic pain-early cognitive decline comorbidity among older adults. With funding from NCCIH and
NIA we used mixed methods to iteratively develop a multimodal, theory grounded, group-based mind-body activity
program tailored to the unique needs of older adults with chronic pain and early cognitive decline. The program helps
older adults manage pain, increase cognitive reserves, and increase engagement in activities that are meaningful to them
using quota-based pacing reinforced by a digital monitoring device. The program shows excellent feasibility and
acceptability for virtual delivery and remote data collection. Program participation is associated with improvement in
multimodal physical function (self-report, 6-minute walk test and Actigraph measured stepcount), emotional function
(depression and anxiety), cognitive function (self-report and objective), pain intensity and theory informed mediators.
Building on our promising study we now propose to conduct a fully powered RCT of our mind-body activity program
(Active Brains-Digital) versus an educational control (Health Enhancement Program) both delivered virtually among
N=260 older adults with musculoskeletal chronic pain and early cognitive decline. We will establish efficacy of Active
Brains-Digital, sustainability of improvement over 6 months, and mechanisms of change through relevant mediators and
moderators. The trial will take place at the Massachusetts General Hospital using our established methodology and
infrastructure. Active Brains-Digital has the potential to be the first evidence-based program for older adults with
chronic pain and early cognitive decline, with important implications for prevention of AD/ADRD in this high risk
population. This project directly aligns with NIA strategic Goal C, objectives 1 and 3.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Christine S Ritchie其他文献
Intervention for the management of neuropsychiatric symptoms to reduce caregiver stress: Protocol for the Mindful and Self-compassion Care (MASC) intervention for caregivers of persons living with dementia (Preprint)
管理神经精神症状以减轻护理人员压力的干预措施:针对痴呆症患者护理人员的正念和自我同情护理 (MASC) 干预方案(预印本)
- DOI:
- 发表时间:
2024 - 期刊:
- 影响因子:1.7
- 作者:
Aniyah Travis;Arden O’Donnell;Natalia Giraldo;Sarah M. Stone;Daniel Torres;Shelley R Adler;A. Vranceanu;Christine S Ritchie - 通讯作者:
Christine S Ritchie
Christine S Ritchie的其他文献
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{{ truncateString('Christine S Ritchie', 18)}}的其他基金
Bridging the Science-to-Service Gap in Aging Care: Prevention, Optimization and Living Well with Persistent or Serious Illnesses
缩小老年护理中科学与服务的差距:持续或严重疾病的预防、优化和健康生活
- 批准号:
10638577 - 财政年份:2023
- 资助金额:
$ 59.47万 - 项目类别:
Addressing the chronic pain-early cognitive decline comorbidity among older adults; The Active Brains study
解决老年人慢性疼痛-早期认知能力下降的合并症;
- 批准号:
10370093 - 财政年份:2022
- 资助金额:
$ 59.47万 - 项目类别:
Addressing the chronic pain epidemic among older adults in underserved community center; The GetActive+ study.
解决服务不足的社区中心老年人中流行的慢性疼痛问题;
- 批准号:
10536153 - 财政年份:2022
- 资助金额:
$ 59.47万 - 项目类别:
The Mindful and Self-Compassionate Care Program (MASC): Reducing Stress for Caregivers of Persons with Dementia
正念和自我关怀护理计划 (MASC):减轻痴呆症患者护理人员的压力
- 批准号:
10505172 - 财政年份:2022
- 资助金额:
$ 59.47万 - 项目类别:
Addressing the chronic pain epidemic among older adults in underserved community center; The GetActive+ study (McDermott-Career Enhancement Supplement)
解决服务不足的社区中心老年人中流行的慢性疼痛问题;
- 批准号:
10789061 - 财政年份:2022
- 资助金额:
$ 59.47万 - 项目类别:
Palliative Care Research Cooperative Group (PCRC): Investigator Development Center
姑息治疗研究合作小组 (PCRC):研究者发展中心
- 批准号:
10438802 - 财政年份:2013
- 资助金额:
$ 59.47万 - 项目类别:
Palliative Care Research Cooperative Group (PCRC): Investigator Development Center
姑息治疗研究合作小组 (PCRC):研究者发展中心
- 批准号:
10207786 - 财政年份:2013
- 资助金额:
$ 59.47万 - 项目类别:
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