Anger Rumination in the Development of Psychopathology

精神病理学发展中的愤怒反思

• 批准号: 10378144
• 负责人: Jessica Rachael Peters
• 金额: $ 19.08万
• 依托单位: BROWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-04-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10378144
• 关键词: Adolescence; Adolescent; Affect; Aggressive behavior; Anger; Anterior; Area; Arousal; Behavior; Behavioral; Behavioral Mechanisms; Biological; Borderline Personality Disorder; Characteristics; Clinical; Clinical Research; Conscious; Data; Data Analyses; Development; Disease; Disinhibition; Distress; Early Intervention; Eating Disorders; Emotional; Emotions; Ethical Issues; Feeling; Female Adolescents; Food; Functional Magnetic Resonance Imaging; Funding; Goals; Habits; Health system; Hostility; Impairment; Impulsive Behavior; Impulsivity; Individual; Institution; Insula of Reil; Intervention; K-Series Research Career Programs; Knowledge; Link; Mental Health; Mentorship; Methodology; Modeling; Monitor; Motivation; Negative Reinforcements; Neurobiology; Neurologic; Nucleus Accumbens; Outcome; Pain management; Participant; Pathway Analysis; Pattern; Population; Positive Reinforcements; Preventive screening; Process; Psychopathology; Public Health; Recording of previous events; Regulation; Research; Research Personnel; Research Training; Rewards; Risk; Risk Factors; Role; Sampling; Self-Direction; Self-Injurious Behavior; Shame; Substance Use Disorder; Suicide; Symptoms; System; Testing; Time; To specify; Training; Translational Research; United States National Institutes of Health; Universities; Validation; Veins; Woman; aged; base; behavioral pharmacology; behavioral response; career development; cognitive process; cost; depressive symptoms; design; effective intervention; emotion regulation; empowerment; experience; externalizing behavior; follow-up; imaging study; learning network; negative affect; network models; neural circuit; neural correlate; neuromechanism; pleasure; preventive intervention; programs; recruit; relating to nervous system; response; rumination; sex; skills; theories; trait; vulnerable adolescent; young adult

PROJECT SUMMARY/ABSTRACT BPD is a serious and costly public health problem. To develop effective preventative and early interventions for BPD as symptoms emerge across adolescence, it is crucial to understand the biological and behavioral mechanisms via which a subset of adolescents vulnerable to negative emotions also develop the relational and behavioral dysregulation that makes BPD so challenging to treat. Rumination on anger may amplify anger as a preferred state to shame and feelings of rejection, while contributing to the dysregulation typical of BPD. Unlike other negative emotions, anger increases both arousal and approach motivation. Accordingly, AR may not only dampen BPD individuals’ self-directed negative affect (negative reinforcement), but also provide them with feelings of validation, empowerment, and pleasure (positive reinforcement). This theory suggests a potential neural mechanism contributing to BPD development: sensitization of the dopaminergic reward system localized within the nucleus accumbens (NAcc) to repeated engagement in AR. The proposed study’s central hypothesis is that repeated use of AR as an emotion regulation strategy to manage the pain of rejection is immediately rewarding, but with the cost of increased risk of the wide range of dysfunctional, impulsive behaviors characteristic of BPD. The neural circuitry of rejection and AR will be examined in a non-clinical sample of adolescent girls (N=60) aged 13-16, with heightened emotional vulnerability and endorsing a range of AR. To examine AR-related NAcc recruitment, following assessments, participants will engage in fMRI- monitored paradigms involving interpersonal rejection, and subsequent prompts to engage in angry, depressive, positive and neutral thought. Neural correlates of AR will be used to predict BPD features and related outcomes at 6 and 12 months, as well as networks modeling the interplay among BPD features, including links between internalized negative affect and dysregulated behavior. The training plan closely matches the proposed research and long-term goals with an emphasis on activities that will facilitate the candidate’s development as an independent investigator. Specifically, the training aims are to: (1) Gain experience in translational research with adolescents, including ethical issues with this protected population; (2) Acquire the theoretical and methodological skills required for designing, implementing, and analyzing data from fMRI studies; (3) Learn network analysis and apply these skills to the assessment of psychopathology. A mentorship team with expertise across these areas has been assembled, and Brown University is a world- renowned clinical research institution with an extensive history of NIH funding and supporting career development awards. Overall, the broad aim of these research and training goals is to support the candidate’s development of an independent research program examining maladaptive anger regulation as a potential biologically-based intervention target in the development of BPD and other forms of psychopathology.

项目概要/摘要 BPD 是一个严重且代价高昂的公共卫生问题。制定有效的预防和早期干预措施 BPD 症状在青春期出现，了解其生物学和行为特征至关重要 一些容易受到负面情绪影响的青少年也通过这种机制发展了关系和 行为失调使得边缘性人格障碍很难治疗。对愤怒的沉思可能会放大愤怒 与羞耻感和被拒绝感相比，人们更喜欢这种状态，同时也会导致边缘性人格障碍典型的失调。不像 与其他负面情绪相比，愤怒会增加唤醒度和接近动机。因此，AR不仅可以 抑制 BPD 个体的自我导向负面影响（负面强化），同时也为他们提供 验证、授权和快乐的感觉（积极强化）。该理论提出了一种潜在的 促进 BPD 发展的神经机制：多巴胺能奖励系统的敏化 位于伏隔核 (NAcc) 内，以反复参与 AR。拟议研究的中心 假设重复使用 AR 作为一种情绪调节策略来控制拒绝的痛苦 立即获得回报，但代价是各种功能失调、冲动的风险增加 BPD 的行为特征。排斥和 AR 的神经回路将在非临床中进行检查 13-16 岁青春期女孩样本 (N=60)，她们情绪脆弱，认可的范围 的 AR。为了检查与 AR 相关的 NAcc 招募，在评估之后，参与者将参与 fMRI- 监控涉及人际拒绝的范式，并随后提示进行愤怒、 抑郁、积极和中立的思想。 AR 的神经相关性将用于预测 BPD 特征和 6 个月和 12 个月时的相关结果，以及对 BPD 特征之间相互作用进行建模的网络， 包括内在的负面影响和失调行为之间的联系。培训计划紧密结合 将拟议的研究与长期目标相匹配，重点关注有助于促进 候选人作为独立调查员的发展。具体而言，培训目标是：（1）获得 对青少年进行转化研究的经验，包括与这一受保护人群有关的伦理问题； (2) 获得设计、实施和分析数据所需的理论和方法技能 来自功能磁共振成像研究； (3)学习网络分析并将这些技能应用于精神病理学的评估。一个 布朗大学已经组建了具有这些领域专业知识的导师团队，是一所世界级的大学。 著名的临床研究机构，拥有 NIH 资助和支持事业的悠久历史 发展奖。总体而言，这些研究和培训目标的总体目标是支持候选人的 制定一项独立研究计划，将适应不良的愤怒调节视为一种潜在的方法 BPD 和其他形式的精神病理学发展中基于生物学的干预目标。

项目成果

A daily diary study of minority stressors, suicidal ideation, nonsuicidal self-injury ideation, and affective mechanisms among sexual and gender minority youth.

对性少数和性别少数青少年的少数压力源、自杀意念、非自杀自残意念以及情感机制进行每日日记研究。

• DOI: 10.1037/abn0000813
• 发表时间: 2023
• 期刊: Journal of psychopathology and clinical science
• 作者: Mereish,EthanH;Peters,JessicaR;Brick,LeslieAD;Killam,MatthewA;Yen,Shirley
• 通讯作者: Yen,Shirley

Borderline personality disorder symptom networks across adolescent and adult clinical samples: examining symptom centrality and replicability.

• DOI: 10.1017/s0033291721004931
• 发表时间: 2023-05
• 期刊: PSYCHOLOGICAL MEDICINE
• 影响因子: 6.9
• 作者: Peters, Jessica R.;Crowe, Michael L.;Morgan, Theresa;Zimmerman, Mark;Sharp, Carla;Grilo, Carlos M.;Sanislow, Charles A.;Shea, M. Tracie;Zanarini, Mary C.;McGlashan, Thomas H.;Morey, Leslie C.;Skodol, Andrew E.;Yen, Shirley
• 通讯作者: Yen, Shirley

Association of Borderline Personality Disorder Criteria With Suicide Attempts: Findings From the Collaborative Longitudinal Study of Personality Disorders Over 10 Years of Follow-up.

• DOI: 10.1001/jamapsychiatry.2020.3598
• 发表时间: 2020-11
• 期刊: JAMA psychiatry
• 影响因子: 25.8
• 作者: S. Yen;S. Yen;Jessica R. Peters;Shivani Nishar;C. Grilo;C. Sanislow;M. Shea;M. Zanarini;T. McGlashan;L. Morey;A. Skodol

Improving rigor through gender inclusivity in reproductive psychiatric science.

• DOI: 10.1016/j.cpnec.2023.100194
• 发表时间: 2023-11
• 期刊: COMPREHENSIVE PSYCHONEUROENDOCRINOLOGY
• 作者: Peters, Jessica R.;Stumper, Allison;Schmalenberger, Katja M.;Taubman, Andy J.;Eisenlohr-Moul, Tory A.
• 通讯作者: Eisenlohr-Moul, Tory A.

Association between Shame Aversion and Ruminative Retribution: Evidence for Moderation by Externalization of Blame and Control.

• DOI: 10.1007/s11031-021-09901-6
• 发表时间: 2021-12
• 期刊: Motivation and emotion
• 影响因子: 4.8
• 作者: Schoenleber M;Beltran E;Peters JR;Anestis MD
• 通讯作者: Anestis MD