Anger Rumination in the Development of Psychopathology

精神病理学发展中的愤怒反思

• 批准号: 9526677
• 负责人: Jessica Rachael Peters
• 金额: $ 19.47万
• 依托单位: BROWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-04-01 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9526677
• 关键词: Adolescence; Adolescent; Affect; Aggressive behavior; Anger; Anterior; Area; Arousal; Behavior; Behavioral; Behavioral Mechanisms; Biological; Borderline Personality Disorder; Characteristics; Clinical; Clinical Research; Conscious; Data; Data Analyses; Development; Disease; Disinhibition; Distress; Early Intervention; Eating Disorders; Emotional; Emotions; Ethical Issues; Feeling; Female Adolescents; Food; Functional Magnetic Resonance Imaging; Funding; Goals; Habits; Health system; Hostility; Image Analysis; Impairment; Impulsive Behavior; Impulsivity; Individual; Institution; Insula of Reil; Intervention; K-Series Research Career Programs; Knowledge; Link; Mental Health; Mentorship; Methodology; Modeling; Monitor; Motivation; Negative Reinforcements; Neurobiology; Neurologic; Nucleus Accumbens; Outcome; Pain management; Participant; Pathway Analysis; Pattern; Population; Positive Reinforcements; Preventive Intervention; Preventive screening; Process; Psychopathology; Public Health; Rage; Recording of previous events; Regulation; Research; Research Personnel; Research Training; Rewards; Risk; Risk Factors; Role; Sampling; Self-Direction; Self-Injurious Behavior; Shame; Substance Use Disorder; Suicide; Symptoms; System; Testing; Time; To specify; Training; Translational Research; United States National Institutes of Health; Universities; Validation; Veins; Woman; aged; base; behavioral pharmacology; behavioral response; career development; cognitive process; cost; depressive symptoms; design; effective intervention; emotion regulation; empowerment; experience; externalizing behavior; follow-up; imaging study; learning network; negative affect; network models; neural circuit; neural correlate; neuromechanism; pleasure; programs; recruit; relating to nervous system; response; sex; skills; theories; trait; vulnerable adolescent; young adult

PROJECT SUMMARY/ABSTRACT BPD is a serious and costly public health problem. To develop effective preventative and early interventions for BPD as symptoms emerge across adolescence, it is crucial to understand the biological and behavioral mechanisms via which a subset of adolescents vulnerable to negative emotions also develop the relational and behavioral dysregulation that makes BPD so challenging to treat. Rumination on anger may amplify anger as a preferred state to shame and feelings of rejection, while contributing to the dysregulation typical of BPD. Unlike other negative emotions, anger increases both arousal and approach motivation. Accordingly, AR may not only dampen BPD individuals’ self-directed negative affect (negative reinforcement), but also provide them with feelings of validation, empowerment, and pleasure (positive reinforcement). This theory suggests a potential neural mechanism contributing to BPD development: sensitization of the dopaminergic reward system localized within the nucleus accumbens (NAcc) to repeated engagement in AR. The proposed study’s central hypothesis is that repeated use of AR as an emotion regulation strategy to manage the pain of rejection is immediately rewarding, but with the cost of increased risk of the wide range of dysfunctional, impulsive behaviors characteristic of BPD. The neural circuitry of rejection and AR will be examined in a non-clinical sample of adolescent girls (N=60) aged 13-16, with heightened emotional vulnerability and endorsing a range of AR. To examine AR-related NAcc recruitment, following assessments, participants will engage in fMRI- monitored paradigms involving interpersonal rejection, and subsequent prompts to engage in angry, depressive, positive and neutral thought. Neural correlates of AR will be used to predict BPD features and related outcomes at 6 and 12 months, as well as networks modeling the interplay among BPD features, including links between internalized negative affect and dysregulated behavior. The training plan closely matches the proposed research and long-term goals with an emphasis on activities that will facilitate the candidate’s development as an independent investigator. Specifically, the training aims are to: (1) Gain experience in translational research with adolescents, including ethical issues with this protected population; (2) Acquire the theoretical and methodological skills required for designing, implementing, and analyzing data from fMRI studies; (3) Learn network analysis and apply these skills to the assessment of psychopathology. A mentorship team with expertise across these areas has been assembled, and Brown University is a world- renowned clinical research institution with an extensive history of NIH funding and supporting career development awards. Overall, the broad aim of these research and training goals is to support the candidate’s development of an independent research program examining maladaptive anger regulation as a potential biologically-based intervention target in the development of BPD and other forms of psychopathology.

项目总结/摘要 BPD是一个严重且昂贵的公共卫生问题。制定有效的预防和早期干预措施， BPD作为青春期出现的症状，了解其生物学和行为学特征至关重要。 一部分易受负面情绪影响的青少年也通过这种机制发展了关系， 行为失调，使BPD如此具有挑战性的治疗。沉思愤怒可能会放大愤怒， 更喜欢的状态，羞耻和拒绝的感觉，同时有助于典型的BPD失调。不像 其他负面情绪，愤怒增加唤醒和接近动机。因此，AR不仅可以 抑制BPD个体的自我导向负面影响（负强化），但也为他们提供 确认、授权和快乐的感觉（正强化）。这一理论表明， 促进BPD发展的神经机制：多巴胺能奖赏系统的敏化 定位于丘脑核（NAcc）内以重复参与AR。该研究的核心是 假设是，重复使用AR作为情绪调节策略来管理拒绝的痛苦， 立即奖励，但与成本增加的风险范围广泛的功能失调，冲动 BPD的行为特征将在非临床研究中检查排斥和AR的神经回路。 年龄在13-16岁的青春期女孩样本（N=60），具有高度的情感脆弱性，并支持一系列 的AR。为了检查AR相关的NAcc募集，在评估之后，参与者将进行fMRI- 监测范式涉及人际拒绝，以及随后的提示，从事愤怒， 消极、积极和中性的思想。AR的神经相关性将用于预测BPD特征， 6个月和12个月时的相关结局，以及BPD特征之间相互作用的网络建模， 包括内在化的负面影响和失调行为之间的联系。培训计划紧密结合 与拟议的研究和长期目标相匹配，重点是将促进 候选人作为独立调查员的发展。具体而言，培训的目的是：（1）获得 青少年转化研究经验，包括受保护人群的伦理问题; (2)获得设计，实施和分析数据所需的理论和方法技能 （3）学习网络分析并将这些技能应用于精神病理学的评估。一 拥有这些领域专业知识的导师团队已经组建，布朗大学是一个世界- 著名的临床研究机构，拥有NIH资助和支持事业的广泛历史 发展奖。总的来说，这些研究和培训目标的主要目的是支持候选人的 开发一个独立的研究项目，研究适应不良的愤怒调节作为一种潜在的 在BPD和其他形式的精神病理学的发展中以生物为基础的干预目标。