Segmenting Brain Structures for Neurological Disorders

分割神经系统疾病的大脑结构

• 批准号: 10295766
• 负责人: Bruce Fischl
• 金额: $ 49.97万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-12-01 至 2023-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10295766
• 关键词: Affect; Aging; Algorithmic Analysis; Algorithms; Alzheimer' s Disease; Anatomy; Atlases; Brain; Brain Stem; Cell Nucleus; Chemicals; Claustral structure; Code; Coma; Consciousness Disorders; Data; Data Set; Diagnosis; Diffusion; Disease; Documentation; Ensure; Future; Generations; Globus Pallidus; Habenula; Histologic; Histology; Human; Image; Image Analysis; Infrastructure; Label; Licensing; Location; MRI Scans; Magnetic Resonance Imaging; Manuals; Methods; Modeling; Neurobiology; Parkinson Disease; Phase II Clinical Trials; Phase III Clinical Trials; Physiology; Population; Procedures; Protocols documentation; Publishing; Red nucleus structure; Reproducibility; Research; Research Design; Research Personnel; Resolution; Resources; Rest; Scanning; Source; Speed; Staging; Stress; Structure; Structure of subthalamic nucleus; Substantia nigra structure; System; Techniques; Technology; Test Result; Testing; Thalamic Nuclei; Therapeutic Intervention; Time; Validation; Ventral Tegmental Area; Visualization; Visualization software; Work; algorithm development; base; capsule; design; ex vivo imaging; flexibility; histological image; human disease; imaging Segmentation; in vivo; interest; morphometry; nervous system disorder; open source; open source tool; power analysis; segmentation algorithm; skills; support tools; targeted treatment; tool; tractography; ultra high resolution; web site; wiki

Abstract Magnetic Resonance Imaging (MRI) is a flexible and powerful technology for quantifying the effects of many conditions, including numerous neurological disorders, on human brain anatomy, connectivity, vasculature, chemical composition, physiology and function. In the past 15 years, several open source tools have been developed that accurately and automatically segment an array of brain structures. In this project, we seek the resources to extend this set to enable the quantification of neuroanatomical changes that are critical to diagnosing, staging and assessing the efficacy of potential therapeutic interventions in diseases such as Alzheimer’s and Parkinson’s. This includes the acquisition of datasets to enable manual labeling of structures of interest, the generation of documentation, tutorials, unit tests, regression tests and system tests to harden the tools and make them usable by clinicians and neuroscientists, and finally the distribution and support of the data, manual labelings and tools to the more than 32,000 researchers that use FreeSurfer through our existing open source mechanism.

摘要