Immuno-Engineering: Integrated Engineering and Immunology Training

免疫工程：综合工程和免疫学培训

• 批准号: 10641323
• 负责人: Avery August
• 金额: $ 4.93万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10641323
• 关键词: Engineering; Immunology; Training; immunoengineering

Project Summary / Abstract This application seeks support for a training program in immuno-engineering at Cornell University. This program supports the training of 4 pre-doctoral students who have begun their thesis research. The goal of this T32 training grant is to provide pre-doctoral students in engineering and immunology broad training in Immuno-engineering, from studying single molecules to whole animals, to improve the lives of patients. The unique aspect of this program is that training opportunities are available that enhance the interactions between engineers and immunologists, with a combination of 17 immunology and engineering faculty will serve as faculty Trainers. They represent a range of expertise including the innate immune response system, adaptive immune system, allergy, asthma, autoimmune and inflammatory diseases, response to infectious agents, cell and tissue engineering, polymer chemistry, protein engineering, biomaterials, biocompatibility, drug delivery, molecular design, fluid dynamics, whole animal imaging, micro- nano-fabrication and technologies, and point-of-care technologies. Graduate students in their second year and beyond will be selected from several existing graduate Fields in engineering, for support starting in their third year. Selection will be based upon academic and research promise of the student, the quality and relevance of their thesis work to work in immuno-engineering, and aspirations to conduct independent research in this area. Engineering trainees can obtain a Graduate Minor degree in Immunology, and participate in several activities related to the training theme including: a unique immuno-engineering course, a unique clinical immersion experience, an immuno-engineering Journal Club; the Immunology & Infectious Disease Journal Club; the Seminars in Infection & Immunity and other related to bioengineering and immunology; ethics training; career development activities in collaboration with the Cornell BEST program and Cornell University Center for the Integration of Research, Teaching (CU-CIRTL), and relevant external conferences and courses. Selection of students and monitoring of their ongoing and postgraduate career progress will be overseen by an Executive Committee and Program-assigned mentor, their Special (or thesis) committee, and an External Advisory Board. Coupled with an exceptional tradition of dedication to training academic researchers this program will arm trainees with comprehensive training that will make them exceptionally well qualified to be leaders in the emerging area of immuno-engineering.

项目总结/摘要 此申请寻求康奈尔大学免疫工程培训计划的支持。这 该计划支持4名博士生谁已经开始他们的论文研究的培训。的目标 这T32培训补助金是提供工程学和免疫学博士预科学生广泛 免疫工程培训，从研究单个分子到整个动物，以改善免疫系统。 病人的生命。该计划的独特之处在于，提供培训机会， 工程师和免疫学家之间的互动，结合17个免疫学和 工程学院将担任教师培训师。他们代表了一系列的专业知识，包括先天的 免疫应答系统、适应性免疫系统、变态反应、哮喘、自身免疫和炎症 疾病，对感染因子的反应，细胞和组织工程，聚合物化学，蛋白质工程， 生物材料，生物相容性，药物输送，分子设计，流体动力学，整体动物成像，微 纳米制造和技术，以及护理点技术。研究生在他们的第二年 及以后将选择从几个现有的研究生领域的工程，支持开始在他们的 第三年。选择将基于学生的学术和研究承诺，质量和 他们的论文工作的相关性，在免疫工程工作，并渴望进行独立的 在这个领域的研究。工程实习生可以获得免疫学研究生辅修学位，并且 参加与培训主题相关的几项活动，包括：独特的免疫工程课程， 独特的临床沉浸式体验，免疫工程杂志俱乐部;免疫学与感染 疾病杂志俱乐部;感染与免疫研讨会和其他与生物工程和 免疫学;伦理培训;与康奈尔大学BEST计划合作的职业发展活动 康奈尔大学研究、教学一体化中心（CU-CIRTL），以及相关的外部 会议和课程。学生的选择和监测他们的持续和研究生生涯 进度将由执行委员会和计划指定的导师监督，他们的特别（或论文） 委员会和外部咨询委员会。再加上致力于培训的特殊传统， 学术研究人员，该计划将武装学员全面的培训，使他们 非常有资格成为免疫工程新兴领域的领导者。

项目成果

Spatial mapping of the total transcriptome by in situ polyadenylation.

• DOI: 10.1038/s41587-022-01517-6
• 发表时间: 2023-04
• 期刊: NATURE BIOTECHNOLOGY
• 影响因子: 46.9
• 作者: McKellar, David W.;Mantri, Madhav;Hinchman, Meleana M.;Parker, John S. L.;Sethupathy, Praveen;Cosgrove, Benjamin D.;De Vlaminck, Iwijn
• 通讯作者: De Vlaminck, Iwijn

Analysis of the molecular determinants for furin cleavage of the spike protein S1/S2 site in defined strains of the prototype coronavirus murine hepatitis virus (MHV).

• DOI: 10.1016/j.virusres.2023.199283
• 发表时间: 2024-02
• 期刊: VIRUS RESEARCH
• 影响因子: 5
• 作者: Choi, Annette;Kots, Ekaterina D.;Singleton, Deanndria T.;Weinstein, Harel;Whittaker, Gary R.
• 通讯作者: Whittaker, Gary R.

A modular vaccine platform enabled by decoration of bacterial outer membrane vesicles with biotinylated antigens.

• DOI: 10.1038/s41467-023-36101-2
• 发表时间: 2023-01-28
• 期刊: NATURE COMMUNICATIONS
• 影响因子: 16.6
• 作者: Weyant, Kevin B.;Oloyede, Ayomide;Pal, Sukumar;Liao, Julie;Rivera-De Jesus, Mariela;Jaroentomeechai, Thapakorn;Moeller, Tyler D.;Hoang-Phou, Steven;Gilmore, Sean F.;Singh, Riya;Pan, Daniel C.;Putnam, David;Locher, Christopher;de la Maza, Luis M.;Coleman, Matthew A.;DeLisa, Matthew P.
• 通讯作者: DeLisa, Matthew P.

Large-scale integration of single-cell transcriptomic data captures transitional progenitor states in mouse skeletal muscle regeneration.

• DOI: 10.1038/s42003-021-02810-x
• 发表时间: 2021-11-12
• 期刊: Communications biology
• 影响因子: 5.9
• 作者: McKellar DW;Walter LD;Song LT;Mantri M;Wang MFZ;De Vlaminck I;Cosgrove BD
• 通讯作者: Cosgrove BD