Immunology Training Program-Predoctoral

免疫学培训项目-博士前

• 批准号: 10646422
• 负责人: Brian A Cobb
• 金额: $ 30.26万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-15 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10646422
• 关键词: Immunology; Training Programs; pre-doctoral

Project Summary The Case Western Reserve University (CWRU) School of Medicine (SOM) is a leader in immunology research and education, with a rich history of seminal contributions to the field over many decades, including the discovery of the alternative pathway of complement. The Immunology Training Program Leadership Track (ITP-LT) is a training program within the broader Immunology PhD Program that is built to capitalize on the numerous strengths of the institution and our affiliates, which includes multiple departments at CWRU SOM, University Hospitals Cleveland Medical Center (UHCMC), the Cleveland Clinic Foundation (CCF; including the Lerner Research Institute) and the Louis Stokes VA Medical Center (VAMC), to prepare PhD and MD/PhD scientists for outstanding careers in immunology-related research. The Leadership Track places extra emphasis on developing the next generation of investigative group leaders for academia and industry (pharmaceuticals and biotechnology) as a central goal. Participating mentors provide a rich confluence of basic science, clinical activities and resources, and career development workshops to enrich the training of PhD students as they engage in basic and/or translational research ranging from innate immunity and signaling, T cell biology, antigen processing and presentation, complement, antibody structure and function, and mucosal immunity to research in clinically relevant models of infectious diseases (e.g. tuberculosis, HIV, malaria), immunopathology, transplantation and autoimmunity. Moreover, CWRU SOM has a newly developed Center for Systems Immunology (CSI) and has built a rare reputation for strength in glycoimmunology, or the role of glycans and their binding partners in the immune response. The ITP-LT draws upon these strengths and enjoys the explicit co-sponsorship by the CWRU Department of Pathology, CCF Department of Inflammation and Immunity, CWRU/UHCMC Division of Infectious Diseases, and the CWRU Center for Global Health and Disease. These unique research opportunities are central to the ongoing and future success of the ITP-LT. Training for the PhD degree in the program includes course work, research rotations, formal and informal seminars, a Thesis Proposal Defense/Qualifying Examination, research experience resulting in scholarly publications, career development activities, a PhD dissertation, and a variety of opportunities to come together to share and celebrate the accomplishments of the program's diverse population of trainees.

项目摘要 凯斯西储大学（CWRU）医学院（SOM）是免疫学研究的领导者 和教育，几十年来对该领域的开创性贡献历史悠久，包括发现 补体的替代途径。免疫学培训计划领导轨道（ITP-LT）是一个 在更广泛的免疫学博士课程的培训计划，这是建立在利用众多的 该机构和我们的附属机构，其中包括在CWRU SOM，大学多个部门的优势 医院克利夫兰医疗中心（UHCMC），克利夫兰诊所基金会（CCF;包括Lerner 研究所）和路易斯斯托克斯VA医学中心（VAMC），准备博士和MD/博士科学家 在免疫学相关研究方面的杰出职业。领导力课程特别强调 为学术界和工业界培养下一代调查小组领导人（制药和 生物技术作为核心目标。参与导师提供了基础科学，临床， 活动和资源，以及职业发展研讨会，以丰富博士生的培训，因为他们 从事基础和/或转化研究，包括先天免疫和信号传导，T细胞生物学，抗原 加工与呈递、补体、抗体结构与功能、粘膜免疫等方面进行研究 在传染病的临床相关模型中（例如结核病、HIV、疟疾），免疫病理学， 移植和自身免疫。此外，CWRU SOM拥有一个新开发的系统中心 免疫学（CSI），并建立了一个罕见的声誉，在糖免疫学的力量，或聚糖的作用， 它们在免疫反应中的结合伙伴。ITP-LT利用这些优势，并享受明确的 由CWRU病理学系，CCF炎症和免疫系， CWRU/UHCMC传染病部门和CWRU全球健康和疾病中心。这些 独特的研究机会是中心的ITP-LT的持续和未来的成功。 该计划的学位包括课程工作，研究轮换，正式和非正式的研讨会，论文提案 国防/资格考试，研究经验，导致学术出版物，职业发展 活动、博士论文以及各种聚在一起分享和庆祝的机会 该计划的学员的多样化人口的成就。

项目成果

Cutting edge: TNF receptor-associated factor 4 restricts IL-17-mediated pathology and signaling processes.

• DOI: 10.4049/jimmunol.1200470
• 发表时间: 2012-07-01
• 期刊: Journal of immunology (Baltimore, Md. : 1950)
• 作者: Zepp JA;Liu C;Qian W;Wu L;Gulen MF;Kang Z;Li X
• 通讯作者: Li X

Platelet-localized ST6Gal1 does not impact IgG sialylation.

血小板定位的 ST6Gal1 不会影响 IgG 唾液酸化。

• DOI: 10.1093/glycob/cwad052
• 发表时间: 2023
• 期刊: Glycobiology
• 影响因子: 4.3
• 作者: Glendenning,LeandreM;Zhou,JulieY;Kukan,EmilyN;Gao,Chao;Cummings,RichardD;Joshi,Smita;Whiteheart,SidneyW;Cobb,BrianA
• 通讯作者: Cobb,BrianA

Gasdermin E permits interleukin-1 beta release in distinct sublytic and pyroptotic phases.

• DOI: 10.1016/j.celrep.2021.108998
• 发表时间: 2021-04-13
• 期刊: Cell reports
• 影响因子: 8.8
• 作者: Zhou B;Abbott DW
• 通讯作者: Abbott DW

Glycoform-selective prion formation in sporadic and familial forms of prion disease.

• DOI: 10.1371/journal.pone.0058786
• 发表时间: 2013
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Xiao X;Yuan J;Haïk S;Cali I;Zhan Y;Moudjou M;Li B;Laplanche JL;Laude H;Langeveld J;Gambetti P;Kitamoto T;Kong Q;Brandel JP;Cobb BA;Petersen RB;Zou WQ
• 通讯作者: Zou WQ

A novel IL-17 signaling pathway controlling keratinocyte proliferation and tumorigenesis via the TRAF4-ERK5 axis.

• DOI: 10.1084/jem.20150204
• 发表时间: 2015-09-21
• 期刊: The Journal of experimental medicine
• 作者: Wu L;Chen X;Zhao J;Martin B;Zepp JA;Ko JS;Gu C;Cai G;Ouyang W;Sen G;Stark GR;Su B;Vines CM;Tournier C;Hamilton TA;Vidimos A;Gastman B;Liu C;Li X
• 通讯作者: Li X