Administrative Core

行政核心

• 批准号: 10663872
• 负责人: David S. Bradley
• 金额: $ 71.61万
• 依托单位: UNIVERSITY OF NORTH DAKOTA
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-05-13 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10663872
• 关键词: Advisory Committees; Applications Grants; Area; Big Data; Bioinformatics; COVID-19 testing; Career Mobility; Cell Separation; Center for Translational Science Activities; Centers of Research Excellence; Clinic; Clinical; Collaborations; Collection; Core Facility; Data Analyses; Dedications; Disease; Ensure; Epigenetic Process; Evaluation; Event; Extramural Activities; Flow Cytometry; Fostering; Funding; Goals; Graduation Rates; Grant; Grant Review; Grooming; Hand; Health; Health Sciences; Histology; Human; Image; Image Cytometry; Immune response; Individual; Inflammatory; Journals; Mentors; Microbe; Nature; North Dakota; Outcome; Peripheral; Phase; Productivity; Program Development; Publications; Research; Research Infrastructure; Research Personnel; Research Support; Resources; Sampling; Series; Services; Support Groups; Therapeutic; United States National Institutes of Health; Work; biomedical scientist; career; career development; clinical translation; education resources; gut dysbiosis; high throughput analysis; host-microbe interactions; immunoregulation; medical schools; meetings; member; microbial community; novel; pandemic disease; pathogen; pathogenic bacteria; pathogenic virus; programs; recruit; retention rate; service providers; success; symposium

Summary The goal of Administrative Core in Phase 2 is to continue centralizing and managing resources necessary to enhance the success of the COBRE on Host-pathogen Interactions (HPI). Building on the success of Phase 1, this Core will provide support to investigators focused on determining the mechanisms underlying immune modulations in the host upon interaction with various microbes to identify possible treatments for devastating inflammatory diseases. Specifically, the concerted effort will focus on (1) expanding the research enterprise of this center by supporting and recruiting junior investigators working on host-microbe interactions that are central to human health and diseases; (2) facilitating productive scientific interactions by organizing networking opportunities through annual symposium and seminar series ; (3) providing an individualized and tailored mentoring program for each investigator; 4) providing oversight and support for mentoring programs through Internal and External Advisory Committees with regular meetings; 5) raising the national profile of the group by providing cutting edge infrastructural support; 6) establishing a new Computational Data Analysis Core facility to provide cutting-edge bioinformatics analytical and interpretative support for the group; 6) providing administrative support to the existing Cores (Histology, Imaging and Flow Cytometry; and 7) fostering collaboration between the other North Dakota COBRE, INBRE and CTR DaCCoTA grant supported groups and between individuals in the respective groups. Successful completion of these goals in Phase 2 of our COBRE will elevate this center to a nationally recognized level with a group dedicated to understanding various aspects of host-microbe interactions in human health and disease. With the recent funding of a Phase 2 Epigenetics COBRE and a Phase I Clinical Translational Research Center DaCCoTA, our HPI COBRE Phase 2 has an unprecedented opportunity at hand to execute high-quality, cutting edge research of immense therapeutic and clinical potential.

摘要 管理核心在第二阶段的目标是继续集中和管理必要的资源，以 促进关于宿主-病原体相互作用(HPI)的科布雷的成功。在第一阶段取得成功的基础上， 这一核心将为专注于确定免疫机制的调查人员提供支持 宿主与各种微生物相互作用时的调节，以确定可能的破坏性治疗方法 炎症性疾病。具体地说，协调努力将集中在(1)扩大研究企业 该中心通过支持和招募从事宿主-微生物相互作用的初级研究人员 促进人类健康和疾病；(2)通过组织网络促进富有成效的科学互动 通过年度研讨会和系列研讨会提供机会；(3)提供个性化和量身定制的 为每个调查员提供指导计划；4)通过以下方式为指导计划提供监督和支持 有定期会议的内部和外部咨询委员会；5)通过以下方式提高该集团的国家形象 提供尖端基础设施支持；6)建立新的计算数据分析核心设施，以 为集团提供尖端的生物信息学分析和解释支持；6)提供行政管理 支持现有核心(组织学、成像学和流式细胞术)；以及7)促进 其他北达科他州科布雷、INBRE和CTR DaCCoTA赠款支持团体和 各自的组别。在我们的Cobre第二阶段成功完成这些目标将使该中心提升到 国家认可的水平，由一个致力于了解宿主微生物各个方面的小组组成 人类健康与疾病的相互作用。最近资助了一个第二阶段表观遗传学Cobre和一个阶段 I临床转化研究中心DaCCoTA，我们的HPI Cobre二期有了前所未有的机遇 进行具有巨大治疗和临床潜力的高质量、尖端研究。