Center for Excellence in Host Pathogen Interactions

宿主病原体相互作用卓越中心

• 批准号: 10462724
• 负责人: David S. Bradley
• 金额: $ 207.32万
• 依托单位: UNIVERSITY OF NORTH DAKOTA
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-05-13 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10462724
• 关键词: Acute; Affect; Area; Bacterial Infections; Behavior Disorders; Big Data; Businesses; Centers of Research Excellence; Communicable Diseases; Communities; Core Facility; Data Analyses; Development; Disease; Ensure; Epigenetic Process; Extramural Activities; Faculty; Flow Cytometry; Focus Groups; Food Hypersensitivity; Fostering; Funding; Genomics; Giardia; Goals; Grant; Growth; Health; Histology; Human; Image; Immune response; Individual; Infection; Inflammation; Inflammatory; Infrastructure; Interdisciplinary Study; International; Intestines; Investigation; Light; Mentors; Mucous Membrane; Neurodegenerative Disorders; Parasites; Parasitic Diseases; Parasitic infection; Phase; Predisposition; Process; Program Development; Publications; Research; Research Infrastructure; Research Personnel; Research Project Grants; Respiratory syncytial virus; SARS-CoV-2 infection; Science; Scientist; Stream; Support Groups; Surface; Talents; Time; Viral; Virus Diseases; Vision; airway epithelium; anticancer research; career development; career networking; chronic inflammatory disease; cohesion; design; dysbiosis; equipment acquisition; experimental study; gastrointestinal; gut microbiota; gut-brain axis; host-microbe interactions; innovation; interest; microbiome; multidisciplinary; novel; pathogen; programs; respiratory; success

Summary This COBRE Phase 2 application proposes continued support of the UND Center for Excellence in Host- Pathogen interaction (HPI). The long-term goal of this center is to develop a deeper understanding of host responses to viral, bacterial and parasitic insults leading to acute and chronic inflammatory diseases. The vision of this Center is to continue to inspire interest in the study of host-microbe interaction and perform paradigm- shifting science that supports the notion that disease development is an interplay of the interaction between a susceptible host, foreign insult and conducive microenvironment. In Phase 1 this center made significant progress by expanding the number of investigators studying various aspects of infectious and inflammatory diseases (from the initial group of 9 labs to now 18 labs). Since the funding of Phase 1 in 2016, this core group of COBRE investigators has made significant contributions to the field by producing 169 publications, $23,617,386 in extramural funding, and 74 speaking engagements (local, national and international). With the project leader graduation success rate of 80% (4 out 6 investigators graduated with R01 funding) in Phase 1, this Center will continue to promote research on host-microbe interaction by: 1) bringing together four young investigators working cohesively in an integrative, collaborative, and multidisciplinary manner on research encompassing extremely timely COVID-19 infection, intestinal dysbiosis in food allergy, gastrointestinal parasitic infection, and viral interaction with respiratory epithelium; 2) enhance the innovative research capabilities of the Center by supporting 3 existing Phase 1 Core facilities; 3) establishing a new Computational Data Analysis Core to meet the emerging requirements of COBRE investigators; and 4) attract new investigators to the group by supporting pilot grant mechanisms. The ultimate goal is to transition the HPI COBRE to a sustainable, well- organized academic center which will serve as a conduit for increased interaction between investigators from diverse backgrounds with a thematic interest in pursuing research on various aspects of host-microbe interactions.

概括 这项COBRE第2阶段申请提出了持续支持主机卓越中心的支持 - 病原体相互作用（HPI）。该中心的长期目标是对主机有更深入的了解 对病毒，细菌和寄生虫侮辱的反应，导致急性和慢性炎症性疾病。愿景 该中心的旨在继续激发人们对研究宿主微相互作用的兴趣并进行范式 - 转移科学支持以下观点，即疾病发展是一个相互作用的相互作用 敏感的主人，外国侮辱和有利的微环境。在第1阶段中，这个中心很重要 通过扩大研究传染和炎症各个方面的研究人员的数量来进步 疾病（从最初的9个实验室到现在的18个实验室）。自2016年第一阶段的资金以来，这个核心小组 COBRE调查人员通过生产169个出版物为该领域做出了重大贡献， $ 23,617,386的校外资金和74次演讲（本地，国家和国际）。与 项目负责人毕业成功率为80％（4位OUT 6调查人员，毕业于R01资金）， 该中心将继续通过以下方式促进对宿主微杆互动的研究 研究人员以整合，协作和多学科的方式进行研究 涵盖了极度及时的共同兴趣19感染，食物过敏，胃肠道寄生虫中的肠道营养不良 感染以及与呼吸上皮的病毒相互作用； 2）增强了创新的研究能力 通过支持3个现有的1阶段核心设施中心； 3）建立新的计算数据分析核心 满足毛cres虫调查人员的新兴要求； 4）将新调查人员吸引到该小组 支持飞行员赠款机制。最终目标是将HPI毛绒转换为可持续，良好的 有组织的学术中心将作为增加研究人员之间相互作用的渠道 具有主题兴趣的不同背景，致力于对宿主 - 摩托车的各个方面进行研究 互动。