Center for Excellence in Host Pathogen Interactions

总结 这COBRE第2阶段的申请建议继续支持UND中心的卓越主机- 病原体相互作用（HPI）。该中心的长期目标是加深对宿主的了解， 对病毒、细菌和寄生虫损伤的反应导致急性和慢性炎性疾病。视觉 该中心的宗旨是继续激发对宿主-微生物相互作用研究的兴趣，并执行范例- 转变科学，支持疾病发展是一个相互作用的概念， 易感宿主、外来侵害和有益微环境。在第一阶段，该中心取得了重大进展， 通过扩大研究感染性和炎症性疾病各个方面的研究人员数量， 疾病（从最初的9个实验室到现在的18个实验室）。自2016年第一阶段资助以来， COBRE调查员的研究成果为该领域做出了重大贡献，出版了169份出版物， 23，617，386美元的校外资金和74个演讲活动（当地，国家和国际）。与 第1阶段项目负责人毕业成功率为80%（6名研究者中有4名毕业于R 01资助）， 该中心将继续通过以下方式促进宿主-微生物相互作用的研究：1）将四个年轻的 研究人员以综合，协作和多学科的方式在研究中紧密合作 包括非常及时的COVID-19感染，食物过敏引起的肠道生态失调，胃肠道寄生虫 感染，以及病毒与呼吸道上皮的相互作用; 2）提高创新研究能力， 通过支持3个现有的第一阶段核心设施建立一个新的计算数据分析核心中心 满足COBRE调查员的新需求;以及4）通过以下方式吸引新的调查员加入该小组 支持试点赠款机制。最终目标是将HPI COBRE过渡到可持续的，良好的- 有组织的学术中心，将作为一个渠道，增加研究人员之间的互动，从 不同的背景，对宿主微生物的各个方面的研究有主题兴趣 交互.

Summary This COBRE Phase 2 application proposes continued support of the UND Center for Excellence in Host- Pathogen interaction (HPI). The long-term goal of this center is to develop a deeper understanding of host responses to viral, bacterial and parasitic insults leading to acute and chronic inflammatory diseases. The vision of this Center is to continue to inspire interest in the study of host-microbe interaction and perform paradigm- shifting science that supports the notion that disease development is an interplay of the interaction between a susceptible host, foreign insult and conducive microenvironment. In Phase 1 this center made significant progress by expanding the number of investigators studying various aspects of infectious and inflammatory diseases (from the initial group of 9 labs to now 18 labs). Since the funding of Phase 1 in 2016, this core group of COBRE investigators has made significant contributions to the field by producing 169 publications, $23,617,386 in extramural funding, and 74 speaking engagements (local, national and international). With the project leader graduation success rate of 80% (4 out 6 investigators graduated with R01 funding) in Phase 1, this Center will continue to promote research on host-microbe interaction by: 1) bringing together four young investigators working cohesively in an integrative, collaborative, and multidisciplinary manner on research encompassing extremely timely COVID-19 infection, intestinal dysbiosis in food allergy, gastrointestinal parasitic infection, and viral interaction with respiratory epithelium; 2) enhance the innovative research capabilities of the Center by supporting 3 existing Phase 1 Core facilities; 3) establishing a new Computational Data Analysis Core to meet the emerging requirements of COBRE investigators; and 4) attract new investigators to the group by supporting pilot grant mechanisms. The ultimate goal is to transition the HPI COBRE to a sustainable, well- organized academic center which will serve as a conduit for increased interaction between investigators from diverse backgrounds with a thematic interest in pursuing research on various aspects of host-microbe interactions.