Center for Excellence In-Host Pathogen Interactions

宿主病原体相互作用卓越中心

• 批准号: 9273562
• 负责人: David S. Bradley
• 金额: $ 208.5万
• 依托单位: UNIVERSITY OF NORTH DAKOTA
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-05-13 至 2021-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9273562
• 关键词: Accounting; Address; Affect; Aging; Applications Grants; Area; Autoimmune Diseases; Bacterial Infections; Biochemical; Biological; Biomedical Research; C-Type Lectins; Calibration; Cause of Death; Cell Surface Receptors; Cells; Centers for Disease Control and Prevention (U.S.); Centers of Research Excellence; Chronic; Collaborations; Communicable Diseases; Contract Services; Core Facility; Development; Discipline; Disease; Disease Outcome; Educational workshop; Emerging Communicable Diseases; Ensure; Epigenetic Process; Equipment; Event; Extramural Activities; Faculty; Financial Support; Flow Cytometry; Focus Groups; Fostering; Funding; Goals; Grant; Growth; Health; Health Sciences; Histology; Hospitals; Host Defense; Human; Human Resources; Immune; Immune response; Immunologics; Incidence; Individual; Infection; Infectious Agent; Institution; Integration Host Factors; International; Intervention; Lead; Leadership; Libraries; Link; Lung; Mentors; Mentorship; Microbiology; Mission; Molecular; Neurodegenerative Disorders; Neurosciences; North Dakota; Parasites; Parasitic Diseases; Pharmaceutical Preparations; Phase; Physicians; Play; Prevention; Process; Regulation; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resistance; Resources; Role; Rural Population; Sepsis; Signal Pathway; Signal Transduction; Students; Talents; Techniques; Toll-like receptors; Universities; Vector-transmitted infectious disease; Viral Vector; Vision; Visit; Wages; animal facility; base; cohesion; combat; cost; effective therapy; expectation; experimental study; genetic approach; immunoregulation; improved; infectious disease model; instrument; man; medical schools; member; method development; multidisciplinary; neuroinflammation; novel; pathogen; programs; public health relevance; success; symposium; uptake

 DESCRIPTION (provided by applicant): The objective of this grant application is to establish a Center of Biomedical Excellence in Host- Pathogen interactions that is highly interactive and consists of a dynamic group of junior investigators whose research focus is on understanding the mechanisms that underline the host respose to various infectious agents. We have proposed five new independent, but cohesive research projects, all led by junior investigators, that will use molecular, biochemical, immunological, and microbiological approaches to study host-pathogen interactions in different infectious disease models. We will define the role that certain host factors such as C-type lectins, Toll-like receptors, and other cell surface receptors that play a major role in the initiation of the host response, and we propose cutting edge, critica research in identifying molecules and signaling pathways that can regulate immune response and inhibit bacterial/pathogen growth. These goals will be accomplished utilizing an integrative approach to link several investigators to understand various infections. To enhance the program further, we have included a translational component as a key facet of this COBRE, which is consistent with our global, strategic mission to address the needs of North Dakota's aging, largely rural population that are prone to infectious diseases such as pulmonary infections, sepsis, neuroinflammation and vector-borne disease. We will also identify novel parasite-induced immune suppressive mechanisms, which could lead to new treatment paradigms for debilitating autoimmune diseases. The rationale for this center is that each individual brings unique expertise and key directions that together can help elucidate the role of immunomodulatory changes in various infectious disease models. This center will nurture a focused group of investigators, and successful completion of our specific aims will result in the establishment of a collaborative and sustainable Center of Excellence in Host-Pathogen interactions capable of attracting the brightest and most talented faculty, students and fellows to conduct world-class research in the burgeoning field of infectious disease. UND is fully committed to ensuring the growth and sustainability of this group even after the COBRE grant ends, which will establish and maintain UND as the emerging infectious disease center in the US.

 描述（由应用程序提供）：本赠款应用的目的是建立一个高度互动的宿主病原体相互作用的生物医学卓越中心，由一个动态的初级研究者组成，其研究重点是理解强调宿主对各种感染者的呼吸的机制。我们提出了五个由初级研究者领导的五个新独立但具有凝聚力的研究项目，这些项目将使用分子，生化，免疫学和微生物学方法来研究不同传染病模型中的宿主 - 病原体相互作用。我们将定义某些宿主因素，例如C型讲座，TOLL样受体以及其他在宿主反应的启动中起主要作用的细胞表面受体，我们提出了最先进的，在识别分子和信号通路方面的关键研究，可以调节免疫/病原体/病原体生长。这些目标将使用综合方法来实现，以将几个研究人员联系起来以了解各种感染。为了进一步增强该计划，我们将翻译成分作为该毛病的关键方面，这与我们的全球战略使命是一致的，该使命是满足北达科他州衰老的需求，这在很大程度上是粗糙的人群，这些人口容易受到感染性疾病，例如肺部感染，脓毒症，神经炎症和载体疾病。我们还将确定新型的寄生虫诱导的免疫抑制机制，这可能导致新的治疗范式使自身免疫性疾病衰弱。该中心的理由是，每个人都带来了独特的专家和关键方向，可以共同帮助阐明各种传染病模型中免疫调节变化的作用。该中心将护理一群重点的调查人员，并成功完成我们的具体目标将导致建立一个协作和可持续的宿主互动中卓越中心，以吸引最聪明，最有才华的教师，学生和研究员， 在传染病的水伤领域进行世界一流的研究。 UND也完全致力于确保该群体的增长和可持续性，即使在鞋底赠款结束后，它将成为美国新兴的传染病中心的建立和维持。