Center for Excellence In-Host Pathogen Interactions

宿主病原体相互作用卓越中心

• 批准号: 9924539
• 负责人: David S. Bradley
• 金额: $ 208.5万
• 依托单位: UNIVERSITY OF NORTH DAKOTA
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-05-13 至 2021-08-04
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9924539
• 关键词: Accounting; Address; Affect; Aging; Applications Grants; Area; Autoimmune Diseases; Bacterial Infections; Biochemical; Biological; Biomedical Research; C-Type Lectins; Calibration; Cause of Death; Cell Surface Receptors; Cells; Centers for Disease Control and Prevention (U.S.); Centers of Research Excellence; Chronic; Collaborations; Communicable Diseases; Contract Services; Core Facility; Development; Discipline; Disease; Disease Outcome; Disease Surveillance; Educational workshop; Emerging Communicable Diseases; Ensure; Epigenetic Process; Equipment; Event; Extramural Activities; Faculty; Financial Support; Flow Cytometry; Focus Groups; Fostering; Funding; Goals; Grant; Growth; Health; Health Sciences; Histology; Hospitals; Host Defense; Human; Human Resources; Immune; Immune response; Immunologics; Incidence; Individual; Infection; Infectious Agent; Institution; Integration Host Factors; International; Intervention; Lead; Leadership; Libraries; Link; Lung infections; Mentors; Mentorship; Microbiology; Mission; Molecular; Neurodegenerative Disorders; Neurosciences; North Dakota; Parasites; Parasitic Diseases; Pharmaceutical Preparations; Phase; Physicians; Play; Prevention strategy; Process; Regulation; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resistance; Resources; Role; Rural Population; Sepsis; Signal Pathway; Signal Transduction; Students; Talents; Techniques; Toll-like receptors; Universities; Vector-transmitted infectious disease; Viral Vector; Vision; Visit; Wages; animal facility; base; cohesion; combat; cost; effective therapy; expectation; experimental study; genetic approach; immunoregulation; improved; infectious disease model; instrument; man; medical schools; member; method development; multidisciplinary; neuroinflammation; novel; pathogen; pathogenic bacteria; programs; public health relevance; success; symposium; uptake; vector-borne

DESCRIPTION (provided by applicant): The objective of this grant application is to establish a Center of Biomedical Excellence in Host- Pathogen interactions that is highly interactive and consists of a dynamic group of junior investigators whose research focus is on understanding the mechanisms that underline the host respose to various infectious agents. We have proposed five new independent, but cohesive research projects, all led by junior investigators, that will use molecular, biochemical, immunological, and microbiological approaches to study host-pathogen interactions in different infectious disease models. We will define the role that certain host factors such as C-type lectins, Toll-like receptors, and other cell surface receptors that play a major role in the initiation of the host response, and we propose cutting edge, critical research in identifying molecules and signaling pathways that can regulate immune response and inhibit bacterial/pathogen growth. These goals will be accomplished utilizing an integrative approach to link several investigators to understand various infections. To enhance the program further, we have included a translational component as a key facet of this COBRE, which is consistent with our global, strategic mission to address the needs of North Dakota's aging, largely rural population that are prone to infectious diseases such as pulmonary infections, sepsis, neuroinflammation and vector-borne disease. We will also identify novel parasite-induced immune suppressive mechanisms, which could lead to new treatment paradigms for debilitating autoimmune diseases. The rationale for this center is that each individual brings unique expertise and key directions that together can help elucidate the role of immunomodulatory changes in various infectious disease models. This center will nurture a focused group of investigators, and successful completion of our specific aims will result in the establishment of a collaborative and sustainable Center of Excellence in Host-Pathogen interactions capable of attracting the brightest and most talented faculty, students and fellows to conduct world-class research in the burgeoning field of infectious disease. UND is fully committed to ensuring the growth and sustainability of this group even after the COBRE grant ends, which will establish and maintain UND as the emerging infectious disease center in the US.

描述（由申请人提供）：本拨款申请的目的是建立一个宿主与病原体相互作用的生物医学卓越中心，该中心具有高度互动性，由一群充满活力的初级研究人员组成，其研究重点是了解强调宿主对各种传染源反应的机制。我们提出了五个新的独立但有凝聚力的研究项目，全部由初级研究人员领导，这些项目将使用分子、生化、免疫学和微生物学方法来研究不同传染病模型中宿主与病原体的相互作用。我们将定义某些宿主因子（例如 C 型凝集素、Toll 样受体和其他细胞表面受体）在宿主反应启动中起主要作用的作用，并提出前沿、关键的研究来识别可以调节免疫反应和抑制细菌/病原体生长的分子和信号通路。这些目标将利用综合方法来实现，将多个研究人员联系起来以了解各种感染。为了进一步加强该计划，我们将转化部分作为 COBRE 的一个关键方面，这符合我们的全球战略使命，即满足北达科他州老龄化人口（主要是农村人口）的需求，这些人口容易患肺部感染、败血症、神经炎症和媒介传播疾病等传染病。我们还将确定新的寄生虫诱导的免疫抑制机制，这可能会为衰弱的自身免疫性疾病带来新的治疗范例。该中心的基本原理是，每个人都带来独特的专业知识和关键方向，共同帮助阐明免疫调节变化在各种传染病模型中的作用。该中心将培养一批专注的研究人员，成功完成我们的具体目标将导致建立一个协作和可持续的宿主-病原体相互作用卓越中心，能够吸引最聪明、最有才华的教师、学生和研究员 在新兴的传染病领域进行世界一流的研究。即使在 COBRE 资助结束后，UND 仍完全致力于确保该小组的增长和可持续性，这将建立并维持 UND 作为美国新兴传染病中心的地位。