Training in Host-Pathogen Interactions

宿主与病原体相互作用的培训

• 批准号: 10630267
• 负责人: VINCENT T LEE
• 金额: $ 13.99万
• 依托单位: UNIV OF MARYLAND, COLLEGE PARK
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10630267
• 关键词: Training; pathogen

The Training Program in Host-Pathogen Interactions (HPI) has supported four (4) predoctoral students per year in the areas of microbial pathogenesis and host defense for the past 9 years. This renewal application seeks to continue our success at this same level and will build upon the many strengths that have been developed at UMCP over these first two funding periods. Our now 29 training faculty are remarkably interactive, allowing our trainees to be exposed to a variety of diverse research techniques and approaches. Multi-disciplinary methodologies to pathogen research will be emphasized to take advantage of our widespread expertise in diverse research areas including biomaterials and nanosciences, computational biology and genomics, microbiology and immunology, and microbial pathogenesis. Trainees in the HPI program will be exposed to a variety of career alternatives, and attend panels and workshops from previous trainees and other professionals who have positions in academia, government, biotech, scientific review, intellectual property, science writing, and entrepreneurship. The didactic component of this training program is organized through the Biological Sciences Training Program (BISI) and the research program is guided by a highly qualified team including the Training Program Co- Directors, an Internal Steering Committee, and an Outside Advisory Committee comprised of experts in bacterial pathogenesis, host defense and T32 administration. Predoctoral students are selected for this program from a large and increasingly qualified applicant pool. Of the 18 trainees supported by the HPI Training Program over the last 5 years, two (2) are from underrepresented populations (11%), and 9/18 trainees (50%) were women. Outcomes of these trainees have been outstanding, with an average of 4 papers per trainee. For the 7 who defended their PhD, the average is 5 papers each and all are now in postdoctoral fellowships (6) or research education (1). Of the 29 faculty trainers, 2 are from underrepresented populations (7%) and 6 are women (21%). This HPI training program takes advantage of the close proximity of UMCP to the NIH, FDA, WRAIR, and the Department of Homeland Security and we have sent students into laboratories from all of these institutions to learn techniques. Finally, our trainees present their research at local, national, and international meetings. Thus, the Training Program in Host- Pathogen Interactions plays a key role in the continued development of HPI at the University of Maryland, College Park.

宿主 - 病原体相互作用（HPI）中的培训计划支持了四（4）个前体 在过去的9年中，每年在微生物发病机理和宿主防御领域的学生。 该续签申请旨在在同一级别上继续我们的成功，并将基于 在前两个资金期间，UMCP已经发展了许多优势。我们现在 29培训教师非常互动，使我们的学员可以接触到各种各样的 多样化的研究技术和方法。病原体的多学科方法论 将强调研究以利用我们在多元化研究方面的广泛专业知识 包括生物材料和纳米科学，计算生物学和基因组学的领域， 微生物学和免疫学以及微生物发病机理。 HPI计划中的学员将是 接触各种职业替代方案，参加以前的面板和研讨会 在学术界，政府，生物技术，科学的学员和其他专业人士 审查，知识产权，科学写作和企业家精神。的教学成分 该培训计划是通过生物科学培训计划（BISI）和 该研究计划由一支高素质的团队指导，包括培训计划共同 董事，内部指导委员会和外部咨询委员会由 细菌发病机理，宿主防御和T32给药专家。专业学生是 从大型且越来越有资格的申请人池中选出该程序。 18名学员 在过去5年的HPI培训计划的支持下，两（2）个来自代表性不足 人口（11％）和9/18学员（50％）是女性。这些受训者的成果已经 出色，平均每个学员有4篇论文。对于捍卫博士学位的7名 平均每份5篇论文，现在所有论文都在博士后奖学金（6）或研究教育中 （1）。在29名教师培训师中，有2名来自代表性不足的人口（7％），有6名是女性 （21％）。该HPI培训计划利用了UMCP与NIH的紧密相邻的优势， FDA，Wrair和国土安全部，我们已将学生送入 来自所有这些机构的实验室学习技术。最后，我们的学员介绍了他们的 在地方，国家和国际会议上进行研究。因此，主持人的培训计划 - 病原体相互作用在大学持续发展中起关键作用 马里兰州，大学公园。

项目成果

Bacteria Floc, but Do They Flock? Insights from Population Interaction Models of Quorum Sensing

• DOI: 10.1128/mbio.00972-19
• 发表时间: 2019-05-01
• 期刊: MBIO
• 影响因子: 6.4
• 作者: Ueda, Hana;Stephens, Kristina;Bentley, William E.
• 通讯作者: Bentley, William E.

Polyplexes assembled from self-peptides and regulatory nucleic acids blunt toll-like receptor signaling to combat autoimmunity.

• DOI: 10.1016/j.biomaterials.2016.11.052
• 发表时间: 2017-02
• 期刊: Biomaterials
• 影响因子: 14
• 作者: Hess KL;Andorko JI;Tostanoski LH;Jewell CM
• 通讯作者: Jewell CM

Impact of dose, route, and composition on the immunogenicity of immune polyelectrolyte multilayers delivered on gold templates.

• DOI: 10.1002/bit.26083
• 发表时间: 2017-03
• 期刊: Biotechnology and bioengineering
• 影响因子: 3.8
• 作者: Zhang P;Andorko JI;Jewell CM
• 通讯作者: Jewell CM

Electronic control of gene expression and cell behaviour in Escherichia coli through redox signalling.

• DOI: 10.1038/ncomms14030
• 发表时间: 2017-01-17
• 期刊: Nature communications
• 影响因子: 16.6
• 作者: Tschirhart T;Kim E;McKay R;Ueda H;Wu HC;Pottash AE;Zargar A;Negrete A;Shiloach J;Payne GF;Bentley WE
• 通讯作者: Bentley WE

A platform of genetically engineered bacteria as vehicles for localized delivery of therapeutics: Toward applications for Crohn's disease.

• DOI: 10.1002/btm2.10113
• 发表时间: 2018-09
• 期刊: Bioengineering & translational medicine
• 影响因子: 7.4
• 作者: McKay R;Ghodasra M;Schardt J;Quan D;Pottash AE;Shang W;Jay SM;Payne GF;Chang MW;March JC;Bentley WE
• 通讯作者: Bentley WE