Training in Host-Pathogen Interactions

宿主与病原体相互作用的培训

• 批准号: 10630267
• 负责人: VINCENT T LEE
• 金额: $ 13.99万
• 依托单位: UNIV OF MARYLAND, COLLEGE PARK
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10630267
• 关键词: Training; pathogen

The Training Program in Host-Pathogen Interactions (HPI) has supported four (4) predoctoral students per year in the areas of microbial pathogenesis and host defense for the past 9 years. This renewal application seeks to continue our success at this same level and will build upon the many strengths that have been developed at UMCP over these first two funding periods. Our now 29 training faculty are remarkably interactive, allowing our trainees to be exposed to a variety of diverse research techniques and approaches. Multi-disciplinary methodologies to pathogen research will be emphasized to take advantage of our widespread expertise in diverse research areas including biomaterials and nanosciences, computational biology and genomics, microbiology and immunology, and microbial pathogenesis. Trainees in the HPI program will be exposed to a variety of career alternatives, and attend panels and workshops from previous trainees and other professionals who have positions in academia, government, biotech, scientific review, intellectual property, science writing, and entrepreneurship. The didactic component of this training program is organized through the Biological Sciences Training Program (BISI) and the research program is guided by a highly qualified team including the Training Program Co- Directors, an Internal Steering Committee, and an Outside Advisory Committee comprised of experts in bacterial pathogenesis, host defense and T32 administration. Predoctoral students are selected for this program from a large and increasingly qualified applicant pool. Of the 18 trainees supported by the HPI Training Program over the last 5 years, two (2) are from underrepresented populations (11%), and 9/18 trainees (50%) were women. Outcomes of these trainees have been outstanding, with an average of 4 papers per trainee. For the 7 who defended their PhD, the average is 5 papers each and all are now in postdoctoral fellowships (6) or research education (1). Of the 29 faculty trainers, 2 are from underrepresented populations (7%) and 6 are women (21%). This HPI training program takes advantage of the close proximity of UMCP to the NIH, FDA, WRAIR, and the Department of Homeland Security and we have sent students into laboratories from all of these institutions to learn techniques. Finally, our trainees present their research at local, national, and international meetings. Thus, the Training Program in Host- Pathogen Interactions plays a key role in the continued development of HPI at the University of Maryland, College Park.

在宿主-病原体相互作用（HPI）的培训计划已支持四（4）博士预科 在过去的9年里，每年都有学生在微生物发病机理和宿主防御领域学习。 此次续约申请旨在延续我们在同一水平上的成功，并将建立在 UMCP在前两个资助期内发展了许多优势。我们的现在 29培训教师是非常互动，让我们的学员接触到各种各样的 多种研究方法和手段。病原体的多学科方法 研究将被强调，以利用我们在不同研究领域的广泛专业知识 包括生物材料和纳米科学，计算生物学和基因组学， 微生物学和免疫学以及微生物致病机理。HPI计划的学员将 接触各种职业选择，并参加以前的小组和研讨会 培训生和其他专业人士谁在学术界，政府，生物技术，科学 评论、知识产权、科学写作和创业。的说教成分 该培训计划通过生物科学培训计划（BISI）组织， 该研究计划是由一个高素质的团队，包括培训计划合作指导， 董事、内部指导委员会和外部咨询委员会， 细菌致病机理、宿主防御和T32给药方面的专家。博士前学生是 从一个庞大的，越来越合格的申请人池选择这个程序。在18名受训人员中， 在过去5年中，在HPI培训计划的支持下，有两（2）人来自代表性不足的国家， 18名受训人员中有9名（50%）是妇女。这些受训人员的成果是 优秀，平均每名学员4篇论文。对于7位博士生来说， 平均是5篇论文，现在都在博士后奖学金（6）或研究教育 （一）.在29名教员培训员中，2人来自代表性不足的人口（7%），6人是妇女 (21%).这个HPI培训计划利用了UMCP与NIH的紧密联系， FDA，WRAIR和国土安全部，我们已经派学生进入 所有这些机构的实验室来学习技术。最后，我们的学员介绍他们的 在地方、国家和国际会议上进行研究。因此，东道国的培训方案- 病原体相互作用在牛津大学HPI的持续发展中起着关键作用。 马里兰州，学院公园。

项目成果

Polyplexes assembled from self-peptides and regulatory nucleic acids blunt toll-like receptor signaling to combat autoimmunity.

• DOI: 10.1016/j.biomaterials.2016.11.052
• 发表时间: 2017-02
• 期刊: Biomaterials
• 影响因子: 14
• 作者: Hess KL;Andorko JI;Tostanoski LH;Jewell CM
• 通讯作者: Jewell CM

Bacteria Floc, but Do They Flock? Insights from Population Interaction Models of Quorum Sensing

• DOI: 10.1128/mbio.00972-19
• 发表时间: 2019-05-01
• 期刊: MBIO
• 影响因子: 6.4
• 作者: Ueda, Hana;Stephens, Kristina;Bentley, William E.
• 通讯作者: Bentley, William E.

A platform of genetically engineered bacteria as vehicles for localized delivery of therapeutics: Toward applications for Crohn's disease.

• DOI: 10.1002/btm2.10113
• 发表时间: 2018-09
• 期刊: Bioengineering & translational medicine
• 影响因子: 7.4
• 作者: McKay R;Ghodasra M;Schardt J;Quan D;Pottash AE;Shang W;Jay SM;Payne GF;Chang MW;March JC;Bentley WE
• 通讯作者: Bentley WE

Electronic control of gene expression and cell behaviour in Escherichia coli through redox signalling.

通过氧化还原信号传导，大肠杆菌中基因表达和细胞行为的电子控制。

• DOI: 10.1038/ncomms14030
• 发表时间: 2017-01-17
• 期刊: Nature communications
• 影响因子: 16.6
• 作者: Tschirhart T;Kim E;McKay R;Ueda H;Wu HC;Pottash AE;Zargar A;Negrete A;Shiloach J;Payne GF;Bentley WE
• 通讯作者: Bentley WE

Impact of dose, route, and composition on the immunogenicity of immune polyelectrolyte multilayers delivered on gold templates.

• DOI: 10.1002/bit.26083
• 发表时间: 2017-03
• 期刊: Biotechnology and bioengineering
• 影响因子: 3.8
• 作者: Zhang P;Andorko JI;Jewell CM
• 通讯作者: Jewell CM