Summer Vision Sciences Training Program

夏季视觉科学培训计划

• 批准号: 10630145
• 负责人: BRIAN P. CERESA
• 金额: $ 3.31万
• 依托单位: UNIVERSITY OF LOUISVILLE
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-01 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10630145
• 关键词: Authorship; Basic Science; Biology; Clinical; Clinical Research; Conflict of Interest; Data; Education; Environment; Faculty; Female; Foundations; Funding; Goals; Homeostasis; Hour; Institutional Review Boards; Interview; Laboratories; Laboratory Research; Medical Students; Mentors; Mentorship; Ophthalmology; Physicians; Plagiarism; Productivity; Publications; Research; Research Personnel; Research Project Grants; Research Training; Retinal Degeneration; Science; Scientist; Series; Structure; Student recruitment; Students; Systems Development; Time; Training; Training Programs; Translational Research; Universities; Uveitis; Vision; Vision research; Visual; Work; animal care; career; corneal epithelium; design; disadvantaged background; drug discovery; ethnic minority; experience; fabrication; human subject; medical schools; peer; posters; programs; responsible research conduct; skills; vision development; vision science

Project Summary/Abstract This is a renewal application for a T35 summer medical student training program in vision research with two Specific Aims: 1) To provide hands-on training in basic and clinical vision research to medical students in a structured mentored environment and 2) To provide an interactive, educational experience that introduces medical students the fundamental skills necessary for basic, translational, and clinical research in vision biology. The co-directors of this program request support for 8 second-year medical students each summer in vision related research laboratories that focus on topics such as visual circuitry, retinal degeneration, corneal epithelial homeostasis, uveitis, ocular drug discovery, and development of the visual system. Trainees will be selected from the first-year class at University of Louisville School of Medicine. Students will review research projects submitted by 18 faculty funded by the NEI or vision related foundations. The directors will make a special effort to recruit students who are underrepresented in science, including females, ethnic minorities and from disadvantaged backgrounds. Students will review the available projects and rank their 1st-5th choices, allowing matching of trainees with mentors. Final decisions will be made based on interviews between mentors and Trainees. During the 10-week summer training, students work with mentors on their research project in laboratory settings, complete training in the Responsible Conduct of Research including topics such as fabrication and falsification of data, plagiarism, managing scientific data, publication practices and responsible authorship, mentorship, stewardship, and conflict of interest. Trainees will complete human subject, IRB training, and animal care and handling as required by their specific research projects. All Trainees will attend a 2-hour weekly “Vision Sciences Research Training Seminar” designed to introduce clinical/translational research in Ophthalmology led by mentors in this T35 program. The seminar series will culminate with each Trainee presenting his/her research project to peers and mentors. In addition, trainees present the results of their research as posters with peers at a School of Medicine-wide, week-long celebration of research (Research!Louisville) that includes nationally recognized physician-scientists as keynote speakers. Trainees will be encouraged to continue research as part of the Distinction in Research track that is an enrichment program focusing on providing meaningful and productive research experiences throughout second through fourth years of medical school, with ongoing presentations by students with mentors and 4+ weeks of research time in the fourth year toward the goal of developing clinician-researchers. Trainees will be tracked to assess the impact of this T35 program on careers as physician-scientists.

项目总结/摘要 这是一个T35暑期医学生视觉研究培训计划的续签申请， 两个具体目标：1）为医学界提供基础和临床视觉研究的实践培训 学生在一个结构化的指导环境和2）提供一个互动的，教育的经验 该课程向医学生介绍了基础，翻译和临床所需的基本技能。 视觉生物学的研究该计划的共同主任要求支持8个第二年的医疗 学生每年夏天在视觉相关的研究实验室，重点是主题，如视觉， 电路，视网膜变性，角膜上皮稳态，葡萄膜炎，眼部药物发现， 视觉系统的发展。学员将从大学一年级学生中选出， 路易斯维尔医学院。学生将审查由18名教师提交的研究项目， NEI或视觉相关基金会。董事们将作出特别努力，招收学生谁是 科学领域代表性不足，包括女性、少数民族和弱势群体 背景学生将审查可用的项目，并将其排名第1-第5位的选择，允许匹配 有导师的学员。最终决定将根据导师之间的面试， 实习生。在为期10周的夏季培训中，学生与导师一起开展研究项目， 实验室设置，完成负责任的研究行为培训，包括以下主题， 捏造和伪造数据，剽窃，管理科学数据，出版实践和 负责任的作者，指导，管理和利益冲突。学员将完成人类 受试者、IRB培训以及动物护理和处理（根据其具体研究项目的要求）。所有 学员将参加每周两小时的“视觉科学研究培训研讨会”， 介绍在T35项目中由导师领导的眼科临床/转化研究。的 研讨会系列将以每位学员向同行介绍他/她的研究项目而告终， 导师此外，学员们还在一所学校的研究所与同龄人一起展示他们的研究成果。 医学界为期一周的研究庆祝活动（研究！路易斯维尔），其中包括全国 公认的医生科学家作为基调发言人。将鼓励学员继续研究 作为研究轨道的区别的一部分，这是一个丰富的计划，重点是提供 在整个第二年到第四年的医疗有意义和富有成效的研究经验 学校，与正在进行的演示由学生与导师和4+周的研究时间在 第四年，以培养临床研究人员为目标。将对受训人员进行跟踪， 这个T35计划对医生科学家职业生涯的影响。

项目成果

Relationship Between Human Meibum Lipid Composition and the Severity of Meibomian Gland Dysfunction: A Spectroscopic Analysis.

• DOI: 10.1167/iovs.64.10.22
• 发表时间: 2023-07-03
• 期刊: Investigative ophthalmology & visual science
• 影响因子: 4.4

Structural Differences in Meibum From Donors After Hematopoietic Stem Cell Transplantations.

造血干细胞移植后供体睑脂的结构差异。

• DOI: 10.1097/ico.0000000000001935
• 发表时间: 2019
• 期刊: Cornea
• 影响因子: 2.8
• 作者: Ramasubramanian,Aparna;Blackburn,Ryan;Yeo,Heegook;Sledge,SamiyyahM;Gully,ZaharaN;Singh,Sharika;Mehta,Sanya;Mehta,Aakash;Yappert,MartaC;Borchman,Douglas
• 通讯作者: Borchman,Douglas

Zeb1 regulation of wound-healing-induced inflammation in alkali-damaged corneas.

• DOI: 10.1016/j.isci.2022.104038
• 发表时间: 2022-04-15
• 期刊: iScience
• 影响因子: 5.8
• 作者: Liang W;Zhang Y;Zhou L;Lu X;Finn ME;Wang W;Shao H;Dean DC;Zhang L;Liu Y
• 通讯作者: Liu Y

Zeb1 facilitates corneal epithelial wound healing by maintaining corneal epithelial cell viability and mobility.

• DOI: 10.1038/s42003-023-04831-0
• 发表时间: 2023-04-20
• 期刊: COMMUNICATIONS BIOLOGY
• 影响因子: 5.9
• 作者: Zhang, Yingnan;Do, Khoi K.;Wang, Fuhua;Lu, Xiaoqin;Liu, John Y.;Li, Chi;Ceresa, Brian P.;Zhang, Lijun;Dean, Douglas C.;Liu, Yongqing
• 通讯作者: Liu, Yongqing

Differences in Meibum and Tear Lipid Composition and Conformation.

• DOI: 10.1097/ico.0000000000002095
• 发表时间: 2020-01
• 期刊: Cornea
• 影响因子: 2.8
• 作者: Borchman D;Ramakrishnan V;Henry C;Ramasubramanian A
• 通讯作者: Ramasubramanian A