Summer Vision Sciences Training Program

夏季视觉科学培训计划

• 批准号: 10630145
• 负责人: BRIAN P. CERESA
• 金额: $ 3.31万
• 依托单位: UNIVERSITY OF LOUISVILLE
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-01 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10630145
• 关键词: Authorship; Basic Science; Biology; Clinical; Clinical Research; Conflict of Interest; Data; Education; Environment; Faculty; Female; Foundations; Funding; Goals; Homeostasis; Hour; Institutional Review Boards; Interview; Laboratories; Laboratory Research; Medical Students; Mentors; Mentorship; Ophthalmology; Physicians; Plagiarism; Productivity; Publications; Research; Research Personnel; Research Project Grants; Research Training; Retinal Degeneration; Science; Scientist; Series; Structure; Student recruitment; Students; Systems Development; Time; Training; Training Programs; Translational Research; Universities; Uveitis; Vision; Vision research; Visual; Work; animal care; career; corneal epithelium; design; disadvantaged background; drug discovery; ethnic minority; experience; fabrication; human subject; medical schools; peer; posters; programs; responsible research conduct; skills; vision development; vision science

Project Summary/Abstract This is a renewal application for a T35 summer medical student training program in vision research with two Specific Aims: 1) To provide hands-on training in basic and clinical vision research to medical students in a structured mentored environment and 2) To provide an interactive, educational experience that introduces medical students the fundamental skills necessary for basic, translational, and clinical research in vision biology. The co-directors of this program request support for 8 second-year medical students each summer in vision related research laboratories that focus on topics such as visual circuitry, retinal degeneration, corneal epithelial homeostasis, uveitis, ocular drug discovery, and development of the visual system. Trainees will be selected from the first-year class at University of Louisville School of Medicine. Students will review research projects submitted by 18 faculty funded by the NEI or vision related foundations. The directors will make a special effort to recruit students who are underrepresented in science, including females, ethnic minorities and from disadvantaged backgrounds. Students will review the available projects and rank their 1st-5th choices, allowing matching of trainees with mentors. Final decisions will be made based on interviews between mentors and Trainees. During the 10-week summer training, students work with mentors on their research project in laboratory settings, complete training in the Responsible Conduct of Research including topics such as fabrication and falsification of data, plagiarism, managing scientific data, publication practices and responsible authorship, mentorship, stewardship, and conflict of interest. Trainees will complete human subject, IRB training, and animal care and handling as required by their specific research projects. All Trainees will attend a 2-hour weekly “Vision Sciences Research Training Seminar” designed to introduce clinical/translational research in Ophthalmology led by mentors in this T35 program. The seminar series will culminate with each Trainee presenting his/her research project to peers and mentors. In addition, trainees present the results of their research as posters with peers at a School of Medicine-wide, week-long celebration of research (Research!Louisville) that includes nationally recognized physician-scientists as keynote speakers. Trainees will be encouraged to continue research as part of the Distinction in Research track that is an enrichment program focusing on providing meaningful and productive research experiences throughout second through fourth years of medical school, with ongoing presentations by students with mentors and 4+ weeks of research time in the fourth year toward the goal of developing clinician-researchers. Trainees will be tracked to assess the impact of this T35 program on careers as physician-scientists.

项目概要/摘要 这是 T35 夏季医学生视觉研究培训项目的续签申请 两个具体目标： 1) 为医学界提供基础和临床视觉研究的实践培训 学生处于结构化的指导环境中，2) 提供互动的教育体验 向医学生介绍基础、转化和临床所需的基本技能 视觉生物学研究。该计划的联合主任请求为 8 名二年级医疗人员提供支持 每年夏天，学生都会在视觉相关的研究实验室里学习，重点研究视觉等主题 电路、视网膜变性、角膜上皮稳态、葡萄膜炎、眼部药物发现和 视觉系统的发展。学员将从大学一年级中选拔 路易斯维尔医学院。学生将审查由 18 名教师提交的研究项目 NEI 或视觉相关基金会。董事们将特别努力招收符合以下条件的学生： 科学界的代表性不足，包括女性、少数民族和弱势群体 背景。学生将审查可用的项目并对他们的第 1-5 个选择进行排名，以便进行匹配 与导师一起的学员。最终决定将根据导师和导师之间的访谈做出 实习生。在为期 10 周的暑期培训期间，学生与导师一起完成他们的研究项目 实验室设置、负责任的研究行为的完整培训，包括以下主题 捏造和伪造数据、剽窃、管理科学数据、出版实践和 负责任的作者身份、指导、管理和利益冲突。学员将完成人类 主题、IRB 培训以及动物护理和处理（根据其具体研究项目的要求）。全部 学员将参加每周 2 小时的“视觉科学研究培训研讨会”，旨在 介绍由 T35 项目导师领导的眼科临床/转化研究。这 研讨会系列将在每位学员向同行和同事展示他/她的研究项目时达到高潮 导师。此外，学员还将他们的研究成果以海报的形式与学校的同行们一起展示。 为期一周的全医学研究庆祝活动（研究！路易斯维尔），包括全国范围内 认可医师科学家作为主讲人。将鼓励学员继续研究 作为“杰出研究”轨道的一部分，该轨道是一项强化计划，专注于提供 在医学第二年到第四年的有意义和富有成效的研究经历 学校，学生在导师的指导下进行持续的演讲，并在该校进行 4 周以上的研究时间 实现培养临床医生研究人员目标的第四年。将跟踪学员以评估 此 T35 计划对医师科学家职业的影响。

项目成果

Relationship Between Human Meibum Lipid Composition and the Severity of Meibomian Gland Dysfunction: A Spectroscopic Analysis.

• DOI: 10.1167/iovs.64.10.22
• 发表时间: 2023-07-03
• 期刊: Investigative ophthalmology & visual science
• 影响因子: 4.4

Structural Differences in Meibum From Donors After Hematopoietic Stem Cell Transplantations.

造血干细胞移植后供体睑脂的结构差异。

• DOI: 10.1097/ico.0000000000001935
• 发表时间: 2019
• 期刊: Cornea
• 影响因子: 2.8
• 作者: Ramasubramanian,Aparna;Blackburn,Ryan;Yeo,Heegook;Sledge,SamiyyahM;Gully,ZaharaN;Singh,Sharika;Mehta,Sanya;Mehta,Aakash;Yappert,MartaC;Borchman,Douglas
• 通讯作者: Borchman,Douglas

Differences in Meibum and Tear Lipid Composition and Conformation.

• DOI: 10.1097/ico.0000000000002095
• 发表时间: 2020-01
• 期刊: Cornea
• 影响因子: 2.8
• 作者: Borchman D;Ramakrishnan V;Henry C;Ramasubramanian A
• 通讯作者: Ramasubramanian A

Zeb1 facilitates corneal epithelial wound healing by maintaining corneal epithelial cell viability and mobility.

• DOI: 10.1038/s42003-023-04831-0
• 发表时间: 2023-04-20
• 期刊: COMMUNICATIONS BIOLOGY
• 影响因子: 5.9
• 作者: Zhang, Yingnan;Do, Khoi K.;Wang, Fuhua;Lu, Xiaoqin;Liu, John Y.;Li, Chi;Ceresa, Brian P.;Zhang, Lijun;Dean, Douglas C.;Liu, Yongqing
• 通讯作者: Liu, Yongqing

Zeb1 regulation of wound-healing-induced inflammation in alkali-damaged corneas.

• DOI: 10.1016/j.isci.2022.104038
• 发表时间: 2022-04-15
• 期刊: iScience
• 影响因子: 5.8
• 作者: Liang W;Zhang Y;Zhou L;Lu X;Finn ME;Wang W;Shao H;Dean DC;Zhang L;Liu Y
• 通讯作者: Liu Y