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Myeloid TGFbeta signaling in breast cancer metastasis

Myeloid TGFbeta signaling in breast cancer metastasis
乳腺癌转移中的骨髓 TGFbeta 信号传导
批准号：
10702491
负责人：
Li Yang
金额：
$100.18万
依托单位：
DIVISION OF BASIC SCIENCES - NCI
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/10702491
关键词：
Breast cancer metastasisCancer BiologyEpithelial CellsFibroblastsGeneticGoalsGrowthImmune responseKnockout MiceMalignant - descriptorMediatingModelingMolecularMusMyelogenousMyeloid CellsNeoplasm MetastasisPathway interactionsPhenotypeRegulationResearchResourcesSignal PathwaySignal TransductionTransforming Growth Factor betaWorkinsightneoplastic cellpromoterreceptortargeted treatmenttumortumor progressiontumor-immune system interactions

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英文摘要
We have made steady progress in the past years. We have produced and bred mouse colonies in which TGFbeta R2 receptor is specifically deleted in myeloid cells. We have observed significantly decreased tumor progression in myeloid TGFbeta R2 ko mice. We obtained mechanistic insight that involves systemic immune response as well as altered local immune microenvironment. We have identified that miRNA130a and miRNA145 directly target myeloid TGFbeta R2 and its associated signaling networks the IGFR pathway. We hope to develop new translational opportunities with the research information obtained. We are utilizing technical core resources and collaborating with several labs for this project.
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