Estradiol Effects on Behavioral and Reward Sensitivity to Alcohol across the Menstrual Cycle
雌二醇对整个月经周期酒精行为和奖赏敏感性的影响
基本信息
- 批准号:10687820
- 负责人:
- 金额:$ 53.87万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-09-25 至 2025-08-31
- 项目状态:未结题
- 来源:
- 关键词:AcuteAdverse effectsAffectAlcohol abuseAlcohol consumptionAlcoholsAnimal ExperimentationAreaBehaviorBehavioralBehavioral MechanismsClinical assessmentsConsumptionDataData ReportingDisinhibitionDoseEstradiolEstrogensExhibitsFemaleGrainHealthHeavy DrinkingHormonalHormonesImpulsivityInterventionInvestigationLaboratoriesLinkLiver CirrhosisLongitudinal StudiesMaintenanceMeasuresMenstrual cycleNeurobiologyOral ContraceptivesOrganOvarian hormoneOvulationOvulation PredictionPatient Self-ReportPatternPeriodicityPhasePhysiologicalPlacebosProgesteronePubertyPublic HealthRecording of previous eventsRelapseResearchRewardsRiskRisk TakingSalivaSamplingSex BehaviorSex DifferencesSubstance abuse problemTestingTheoretical modelVisitWomanWorkabuse liabilityalcohol abuse therapyalcohol cravingalcohol effectalcohol sensitivityalcohol use disorderbinge drinkingcravingdrinking behaviormenneurobehavioralpersonalized interventionproliferative phase Menstrual cyclerelapse preventionreproductivesexual assaulttheoriesuniversity studentyoung adultyoung woman
项目摘要
PROJECT SUMMARY/ABSTRACT
Alcohol use poses significant health problems particularly when characterized by bouts of heavy consumption
(i.e., binges). It is now recognized that women demonstrate greater vulnerability to the adverse effects of
alcohol, including greater physiological risk of organ damage (e.g., liver cirrhosis), than do men with
comparable histories of alcohol use. Research suggests that ovarian hormones play a role in substance abuse.
With regard to alcohol use, there is evidence to suggest that women may exhibit distinct patterns of heavy
drinking across the menstrual cycle. Indeed, our preliminary research shows that surges in follicular estradiol
[E2] at ovulation predict increased alcohol use in young women. Yet, to date no research has aimed to
determine the specific behavioral mechanisms by which rapid surges in E2 confer increased abuse potential of
alcohol. The proposed study directly examines ovarian hormone flux and acute sensitivity to alcohol to provide
the first rigorous and integrative test of the hypothesis that rapid rises in estradiol increase the acute rewarding
and disinhibiting effects of alcohol and that this heightened sensitivity increases alcohol use outside the
laboratory. A sample of 100 naturally-cycling women will be examined daily over their menstrual cycle using an
integrative combination of daily ecological assessments of hormone fluctuations and alcohol use along with
strategically-timed laboratory tests of their acute sensitivity to the rewarding and disinhibiting effects of a
controlled dose of alcohol. The findings will advance understanding of the neurobehavioral mechanisms
linking E2 to alcohol abuse and inform clinical assessment practice by highlighting the importance of menstrual
cycle phase and hormonal profiles when assessing alcohol abuse risk in young women.
项目总结/摘要
饮酒会造成严重的健康问题,特别是当大量饮酒时
(i.e.,狂欢)。现在人们认识到,妇女更容易受到下列因素的不利影响:
酒精,包括更大的器官损伤的生理风险(例如,肝硬化),而男性
相似的饮酒史研究表明,卵巢激素在药物滥用中发挥作用。
关于酒精的使用,有证据表明,妇女可能表现出不同的模式,
在月经周期中饮酒事实上,我们的初步研究表明,卵泡雌二醇的激增
[E2]在排卵期预测年轻女性饮酒量增加。然而,到目前为止,还没有任何研究旨在
确定E2快速激增增加滥用可能性的具体行为机制,
酒精这项研究直接检测了卵巢激素流量和对酒精的急性敏感性,
第一次严格和综合测试的假设,迅速上升的雌二醇增加急性奖励
以及酒精的抑制作用,而且这种高度的敏感性会增加在户外饮酒的情况
实验室100名自然循环妇女的样本将在月经周期内每天使用
激素波动和酒精使用的日常生态评估的综合结合,沿着
战略定时实验室测试他们的急性敏感性的奖励和解除抑制的影响,
控制酒精剂量。这些发现将促进对神经行为机制的理解
将E2与酒精滥用联系起来,并通过强调月经的重要性来告知临床评估实践
评估年轻女性酗酒风险时的周期阶段和激素概况。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Mark T Fillmore其他文献
Mark T Fillmore的其他文献
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{{ truncateString('Mark T Fillmore', 18)}}的其他基金
Impaired Risk Awareness during Intoxication in Recidivist DUI Offenders
酒后驾车累犯醉酒期间风险意识受损
- 批准号:
10491074 - 财政年份:2021
- 资助金额:
$ 53.87万 - 项目类别:
Impaired Risk Awareness during Intoxication in Recidivist DUI Offenders
酒后驾车累犯醉酒期间风险意识受损
- 批准号:
10661079 - 财政年份:2021
- 资助金额:
$ 53.87万 - 项目类别:
Impaired Risk Awareness during Intoxication in Recidivist DUI Offenders
酒后驾车累犯醉酒期间风险意识受损
- 批准号:
10203478 - 财政年份:2021
- 资助金额:
$ 53.87万 - 项目类别:
Estradiol Effects on Behavioral and Reward Sensitivity to Alcohol across the Menstrual Cycle
雌二醇对整个月经周期酒精行为和奖赏敏感性的影响
- 批准号:
10491275 - 财政年份:2020
- 资助金额:
$ 53.87万 - 项目类别:
Estradiol Effects on Behavioral and Reward Sensitivity to Alcohol across the Menstrual Cycle
雌二醇对整个月经周期酒精行为和奖赏敏感性的影响
- 批准号:
10047374 - 财政年份:2020
- 资助金额:
$ 53.87万 - 项目类别:
Estradiol Effects on Behavioral and Reward Sensitivity to Alcohol across the Menstrual Cycle
雌二醇对整个月经周期酒精行为和奖赏敏感性的影响
- 批准号:
10268179 - 财政年份:2020
- 资助金额:
$ 53.87万 - 项目类别:
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