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Estradiol Effects on Behavioral and Reward Sensitivity to Alcohol across the Menstrual Cycle

雌二醇对整个月经周期酒精行为和奖赏敏感性的影响

基本信息

批准号：
10047374
负责人：
Mark T Fillmore
金额：
$ 55.61万
依托单位：
UNIVERSITY OF KENTUCKY
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-25 至 2025-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10047374
关键词：
Acute Adverse effects Affect Alcohol abuse Alcohol consumption Alcohols Animal Experimentation Area Behavior Behavioral Behavioral Mechanisms Clinical assessments Consumption Data Data Reporting Dose Estradiol Estrogens Exhibits Female Grain Health Heavy Drinking Hormonal Hormones Impulsivity Intervention Investigation Laboratories Link Liver Cirrhosis Longitudinal Studies Maintenance Measures Menstrual cycle Neurobiology Oral Contraceptives Organ Ovarian hormone Ovulation Ovulation Prediction Patient Self-Report Pattern Periodicity Phase Physiological Placebos Play Progesterone Puberty Public Health Recording of previous events Relapse Research Rewards Risk Risk-Taking Role Saliva Sampling Sex Behavior Sex Differences Substance abuse problem Testing Theoretical model Visit Woman Work alcohol abuse therapy alcohol craving alcohol effect alcohol sensitivity alcohol use disorder binge drinking craving disorder later incidence prevention drinking behavior men neurobehavioral personalized intervention proliferative phase Menstrual cycle reproductive sexual assault theories university student young adult young woman

项目摘要

PROJECT SUMMARY/ABSTRACT Alcohol use poses significant health problems particularly when characterized by bouts of heavy consumption (i.e., binges). It is now recognized that women demonstrate greater vulnerability to the adverse effects of alcohol, including greater physiological risk of organ damage (e.g., liver cirrhosis), than do men with comparable histories of alcohol use. Research suggests that ovarian hormones play a role in substance abuse. With regard to alcohol use, there is evidence to suggest that women may exhibit distinct patterns of heavy drinking across the menstrual cycle. Indeed, our preliminary research shows that surges in follicular estradiol [E2] at ovulation predict increased alcohol use in young women. Yet, to date no research has aimed to determine the specific behavioral mechanisms by which rapid surges in E2 confer increased abuse potential of alcohol. The proposed study directly examines ovarian hormone flux and acute sensitivity to alcohol to provide the first rigorous and integrative test of the hypothesis that rapid rises in estradiol increase the acute rewarding and disinhibiting effects of alcohol and that this heightened sensitivity increases alcohol use outside the laboratory. A sample of 100 naturally-cycling women will be examined daily over their menstrual cycle using an integrative combination of daily ecological assessments of hormone fluctuations and alcohol use along with strategically-timed laboratory tests of their acute sensitivity to the rewarding and disinhibiting effects of a controlled dose of alcohol. The findings will advance understanding of the neurobehavioral mechanisms linking E2 to alcohol abuse and inform clinical assessment practice by highlighting the importance of menstrual cycle phase and hormonal profiles when assessing alcohol abuse risk in young women.

项目概要/摘要饮酒会带来严重的健康问题，特别是在大量饮酒的情况下（即暴饮暴食）。现在人们认识到，妇女更容易受到性别歧视的不利影响。酒精，包括比患有酒精的男性更大的器官损伤（例如肝硬化）的生理风险类似的饮酒史。研究表明，卵巢激素在药物滥用中发挥着作用。关于饮酒，有证据表明女性可能表现出明显的重度饮酒模式整个月经周期都可以喝酒。事实上，我们的初步研究表明，卵泡雌二醇的激增 [E2] 排卵时预测年轻女性饮酒量增加。然而，迄今为止还没有研究旨在确定 E2 快速激增导致滥用潜力增加的具体行为机制酒精。拟议的研究直接检查卵巢激素通量和对酒精的急性敏感性，以提供对雌二醇快速上升会增加急性奖赏这一假设的首次严格综合检验和酒精的去抑制作用，并且这种高度的敏感性会增加酒精在体外的使用实验室。将使用 100 名自然骑行女性的样本在月经周期内每天进行检查激素波动和酒精使用的日常生态评估的综合组合有策略地定时进行实验室测试，测试他们对某种物质的奖赏和去抑制作用的敏锐敏感性。控制酒精剂量。这些发现将促进对神经行为机制的理解将 E2 与酒精滥用联系起来，并通过强调月经的重要性来为临床评估实践提供信息评估年轻女性酗酒风险时的周期阶段和荷尔蒙概况。