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Estradiol Effects on Behavioral and Reward Sensitivity to Alcohol across the Menstrual Cycle

雌二醇对整个月经周期酒精行为和奖赏敏感性的影响

基本信息

批准号：
10268179
负责人：
Mark T Fillmore
金额：
$ 53.6万
依托单位：
UNIVERSITY OF KENTUCKY
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-25 至 2025-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10268179
关键词：
Acute Adverse effects Affect Alcohol abuse Alcohol consumption Alcohols Animal Experimentation Area Behavior Behavioral Behavioral Mechanisms Clinical assessments Consumption Data Data Reporting Dose Estradiol Estrogens Exhibits Female Grain Health Heavy Drinking Hormonal Hormones Impulsivity Intervention Investigation Laboratories Link Liver Cirrhosis Longitudinal Studies Maintenance Measures Menstrual cycle Neurobiology Oral Contraceptives Organ Ovarian hormone Ovulation Ovulation Prediction Patient Self-Report Pattern Periodicity Phase Physiological Placebos Play Progesterone Puberty Public Health Recording of previous events Relapse Research Rewards Risk Risk-Taking Role Saliva Sampling Sex Behavior Sex Differences Substance abuse problem Testing Theoretical model Visit Woman Work alcohol abuse therapy alcohol craving alcohol effect alcohol sensitivity alcohol use disorder binge drinking craving disorder later incidence prevention drinking behavior men neurobehavioral personalized intervention proliferative phase Menstrual cycle reproductive sexual assault theories university student young adult young woman

项目摘要

PROJECT SUMMARY/ABSTRACT Alcohol use poses significant health problems particularly when characterized by bouts of heavy consumption (i.e., binges). It is now recognized that women demonstrate greater vulnerability to the adverse effects of alcohol, including greater physiological risk of organ damage (e.g., liver cirrhosis), than do men with comparable histories of alcohol use. Research suggests that ovarian hormones play a role in substance abuse. With regard to alcohol use, there is evidence to suggest that women may exhibit distinct patterns of heavy drinking across the menstrual cycle. Indeed, our preliminary research shows that surges in follicular estradiol [E2] at ovulation predict increased alcohol use in young women. Yet, to date no research has aimed to determine the specific behavioral mechanisms by which rapid surges in E2 confer increased abuse potential of alcohol. The proposed study directly examines ovarian hormone flux and acute sensitivity to alcohol to provide the first rigorous and integrative test of the hypothesis that rapid rises in estradiol increase the acute rewarding and disinhibiting effects of alcohol and that this heightened sensitivity increases alcohol use outside the laboratory. A sample of 100 naturally-cycling women will be examined daily over their menstrual cycle using an integrative combination of daily ecological assessments of hormone fluctuations and alcohol use along with strategically-timed laboratory tests of their acute sensitivity to the rewarding and disinhibiting effects of a controlled dose of alcohol. The findings will advance understanding of the neurobehavioral mechanisms linking E2 to alcohol abuse and inform clinical assessment practice by highlighting the importance of menstrual cycle phase and hormonal profiles when assessing alcohol abuse risk in young women.

项目总结/摘要饮酒会造成严重的健康问题，特别是当大量饮酒时 (i.e.,狂欢）。现在人们认识到，妇女更容易受到下列因素的不利影响：酒精，包括更大的器官损伤的生理风险（例如，肝硬化），而男性相似的饮酒史研究表明，卵巢激素在药物滥用中发挥作用。关于酒精的使用，有证据表明，妇女可能表现出不同的模式，在月经周期中饮酒事实上，我们的初步研究表明，卵泡雌二醇的激增 [E2]在排卵期预测年轻女性饮酒量增加。然而，到目前为止，还没有任何研究旨在确定E2快速激增增加滥用可能性的具体行为机制，酒精这项研究直接检测了卵巢激素流量和对酒精的急性敏感性，第一次严格和综合测试的假设，迅速上升的雌二醇增加急性奖励酒精的抑制作用，这种高度的敏感性增加了酒精的使用以外的实验室100名自然循环妇女的样本将在月经周期内每天使用激素波动和酒精使用的日常生态评估的综合结合，沿着战略定时实验室测试他们的急性敏感性的奖励和解除抑制的影响，控制酒精剂量。这些发现将促进对神经行为机制的理解将E2与酒精滥用联系起来，并通过强调月经的重要性来告知临床评估实践评估年轻女性酗酒风险时的周期阶段和激素概况。