Training Program in Translational Cardiovascular Science

项目概要/摘要 本申请寻求更新21 - 25年的转化心血管 医学与公共卫生学院心血管研究中心（CVRC）内的科学（TPTCS）， 威斯康星大学麦迪逊分校CVRC是一个跨学科的研究中心， 来自七所学校和学院的31个部门的教师和研究人员，提供了丰富的 通过基础研究、临床研究、诊断和治疗， 治疗和公共教育。TPTCS培训计划独特地创建了基础研究培训， 博士后MD和博士（四个职位）以及博士前实习生（五个职位），目标是 培养能够"从分子到床边"思考和工作的科学家。实际 近期目标是吸引和培训从事基础研究临床医生，吸引和培训研究生， 博士后（博士）学生在临床动机的基础科学。TPTCS旨在任命医生为 他们的住院医师和研究员培训的一部分是一半的博士后职位。长期以来， 从年度项目评估中产生的项目是它在博士前学生中的整合培训， 基础科学博士后培训生和临床研究员在期刊俱乐部，研讨会上并肩工作 系列，并在实验室的工作台上。这种不同学员观点的融合和分享 该计划的目标的基础，并创建了团队。TPTCS的27名培训员已 从CVRC成员中选出，因为他们的科学在重点领域（心脏）具有临床相关性 失败/再生医学，心律失常/离子通道研究，动脉粥样硬化/血管生物学），他们的 培训记录，以及他们的同行评审研究计划的整体稳健性和活动。培训 发生在威斯康星大学麦迪逊分校，并利用强大的机构支持， 这种培训的环境，以及临床和基础之间建立的工作关系 科学部门和教师都在医学院和公共卫生和大学在 大.培训师和学员都参与核心活动，将该计划定义为一个有凝聚力的实体。 在这次更新中引入了几项创新，包括加强基础科学的临床整合 培训人员和更多的专业发展机会，为所有培训人员的下一阶段做好准备， careers.迄今为止，该方案的任命者非常强大，方案成果也非常出色。 在这个转化心血管科学计划中培训的科学家和医生科学家在 独特的位置，应用基本的科学知识，以造福心血管疾病患者， 美国人死亡的首要原因。

PROJECT SUMMARY/ABSTRACT This application seeks renewal for Years 21-25 of the Training Program in Translational Cardiovascular Science (TPTCS) within the School of Medicine and Public Health Cardiovascular Research Center (CVRC) at the University of Wisconsin-Madison. The CVRC is a campus-wide interdisciplinary research center with faculty and research members from 31 departments in seven schools and colleges, providing a rich environment targeting cardiovascular disease through basic research, clinical investigation, diagnosis and therapy, and public education. The TPTCS training program uniquely creates basic research training for postdoctoral MDs and PhDs (four positions) as well as predoctoral trainees (five positions) with the goal of training scientists who will be capable of thinking and working “from molecule to bedside.” The practical immediate objectives are to attract and train clinicians in basic research, and to attract and train graduate and postdoctoral (PhD) students in clinically motivated basic science. The TPTCS aims to appoint physicians as part of their resident and fellow training to half the postdoctoral positions. One of the long-standing strengths of the program emerging from annual program evaluation is its integration of training among predoctoral students, basic science postdoctoral trainees, and clinical fellows who work side-by-side in journal clubs, in seminar series, and at the bench in laboratories. This blending and sharing of different trainee perspectives is foundational to the goals of the program and creates esprit de corps. The 27 trainers of the TPTCS have been selected from members of the CVRC for the clinical relevance of their science in the focus areas (heart failure/regenerative medicine, arrhythmias/ion channel research, and atherosclerosis/vascular biology), their training records, and the overall robustness and activity of their peer-reviewed research programs. Training takes place at the University of Wisconsin-Madison and exploits the strong institutional support and environment for such training, as well as the established working relationships between clinical and basic science departments and faculty both within the School of Medicine and Public Health and the University at large. Trainers and trainees all participate in core activities that define the program as a cohesive entity. Several innovations are introduced in this renewal, including enhanced clinical integration for the basic science trainees and greater professional development opportunities to prepare all trainees for the next stages in their careers. Appointees to the program to date are extremely strong and program outcomes have been excellent. The scientists and physician-scientists trained in this translational cardiovascular science program are in unique positions to apply basic scientific knowledge to benefit patients with cardiovascular disease, the foremost cause of mortality among Americans.