Training Program in Translational Cardiovascular Science

项目摘要/摘要 此申请寻求续订21-25年的转化性心血管培训计划 医学院和公共卫生心血管研究中心(CVRC)内的科学(TPTCS)，网址为 威斯康星大学麦迪逊分校。CVRC是一个校园范围的跨学科研究中心， 来自7所大专院校31个系的教研员，提供了丰富的 通过基础研究、临床调查、诊断和治疗来针对心血管疾病的环境 治疗和公共教育。TPTCS培训计划独特地为以下人员创建基础研究培训 博士后博士和博士后(四个职位)以及博士后实习生(五个职位)，目标是 培养能够从分子到床边思考和工作的科学家。实用的 近期目标是吸引和培训基础研究方面的临床医生，并吸引和培训毕业生和 具有临床动机的基础科学博士后(博士后)。TPTCS的目标是任命医生为 他们的住院医师和研究员培训的一部分减少到一半的博士后职位。它的长期优势之一是 从年度项目评估中脱颖而出的项目是博士前培养的一体化， 基础科学博士后实习生和临床研究员在期刊俱乐部并肩工作，在研讨会上 系列，并在实验室的长凳上。这种不同学员观点的融合和分享是 对该计划的目标具有基础性意义，并创造了团队精神。TPTCS的27名培训员已经被 从CVRC成员中挑选出他们的科学在重点领域(心脏)的临床相关性 衰竭/再生医学、心律失常/离子通道研究和动脉粥样硬化/血管生物学)，其 培训记录，以及经同行审查的研究方案的总体稳健性和活动。培训 在威斯康星大学麦迪逊分校举行，利用强大的机构支持和 这种培训的环境，以及临床和基础之间已建立的工作关系 医学与公共卫生学院和位于 大号的。培训者和受训者都参加核心活动，这些活动将该计划定义为一个具有凝聚力的实体。 在这次更新中引入了几项创新，包括加强基础科学的临床整合 学员和更大的职业发展机会，为所有学员的下一阶段做好准备 事业。到目前为止，该项目的任命人员非常强大，项目结果一直很好。 在这个翻译心血管科学计划中接受培训的科学家和内科科学家在 应用基础科学知识造福心血管疾病患者的独特职位， 美国人死亡的首要原因。

PROJECT SUMMARY/ABSTRACT This application seeks renewal for Years 21-25 of the Training Program in Translational Cardiovascular Science (TPTCS) within the School of Medicine and Public Health Cardiovascular Research Center (CVRC) at the University of Wisconsin-Madison. The CVRC is a campus-wide interdisciplinary research center with faculty and research members from 31 departments in seven schools and colleges, providing a rich environment targeting cardiovascular disease through basic research, clinical investigation, diagnosis and therapy, and public education. The TPTCS training program uniquely creates basic research training for postdoctoral MDs and PhDs (four positions) as well as predoctoral trainees (five positions) with the goal of training scientists who will be capable of thinking and working “from molecule to bedside.” The practical immediate objectives are to attract and train clinicians in basic research, and to attract and train graduate and postdoctoral (PhD) students in clinically motivated basic science. The TPTCS aims to appoint physicians as part of their resident and fellow training to half the postdoctoral positions. One of the long-standing strengths of the program emerging from annual program evaluation is its integration of training among predoctoral students, basic science postdoctoral trainees, and clinical fellows who work side-by-side in journal clubs, in seminar series, and at the bench in laboratories. This blending and sharing of different trainee perspectives is foundational to the goals of the program and creates esprit de corps. The 27 trainers of the TPTCS have been selected from members of the CVRC for the clinical relevance of their science in the focus areas (heart failure/regenerative medicine, arrhythmias/ion channel research, and atherosclerosis/vascular biology), their training records, and the overall robustness and activity of their peer-reviewed research programs. Training takes place at the University of Wisconsin-Madison and exploits the strong institutional support and environment for such training, as well as the established working relationships between clinical and basic science departments and faculty both within the School of Medicine and Public Health and the University at large. Trainers and trainees all participate in core activities that define the program as a cohesive entity. Several innovations are introduced in this renewal, including enhanced clinical integration for the basic science trainees and greater professional development opportunities to prepare all trainees for the next stages in their careers. Appointees to the program to date are extremely strong and program outcomes have been excellent. The scientists and physician-scientists trained in this translational cardiovascular science program are in unique positions to apply basic scientific knowledge to benefit patients with cardiovascular disease, the foremost cause of mortality among Americans.