Core Center for Musculoskeletal Biology and Medicine (Overall Application)

肌肉骨骼生物学与医学核心中心（整体应用）

• 批准号: 10707598
• 负责人: Tamara N Alliston
• 金额: $ 17.08万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10707598
• 关键词: Acids; Animal Model; Applications Grants; Archives; Area; Back; Basic Science; Biology; Biomechanics; Biometry; Calcium-Sensing Receptors; Clinical; Clinical Data; Clinical Sciences; Collaborations; Communication; Country; Custom; Degenerative polyarthritis; Diagnosis; Digital Libraries; Discipline; Disease; Educational Curriculum; Endocrine; Epidemiology; Etiology; Experimental Designs; Fostering; Fracture; Functional disorder; Funding; Goals; Grant; Health; Histologic; Human; Image; Infrastructure; Insulin-Like Growth Factor I; Investigation; Knowledge; Laboratories; Leadership; Locomotion; Manuscripts; Medical center; Medicine; Metabolic Bone Diseases; Methods; Mission; Musculoskeletal; Musculoskeletal Diseases; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Orthopedic Surgery; Orthopedics; Osteoporosis; PTH gene; Patients; Productivity; Protocols documentation; Publishing; Reagent; Recording of previous events; Reporting; Reproducibility; Research; Research Design; Research Personnel; Research Support; Resources; Role; Science; Scientist; Services; Site; Specialist; Supervision; System; Technology; Tissue Sample; Tissues; Training; Transcend; Translating; Translational Research; United States National Institutes of Health; Visit; base; bench to bedside; biomechanical test; disease phenotype; experience; imaging modality; innovation; interdisciplinary collaboration; longitudinal database; mechanical load; member; men; musculoskeletal imaging; non-invasive imaging; osteoporosis with pathological fracture; pre-clinical; programs; quantitative imaging; reconstruction; skeletal; symposium; synergism; theories; tool

The proposed UCSF Core Center for Musculoskeletal Biology and Medicine (CCMBM) will be an interdisciplinary consortium of 114 basic and clinical scientists dedicated to understanding the biology and pathophysiology of musculoskeletal disease. The goal is to stimulate and support transdisciplinary collaborations amongst existing, premier research programs at UCSF in order to accelerate translational research in musculoskeletal science. A fundamental challenge for bench-to-bedside translational research is the need to validate in humans the findings from small animal models. The proposed CCMBM will overcome this obstacle by forming a linkage between researchers who study disease biology, experts who develop advanced investigational tools and methods, scientists who analyze vast archives of clinical data, and practitioners who actively treat patients. The UCSF CCMBM proposes three cores: 1) Skeletal Biology and Biomechanics Core; 2) Imaging Core; and 3) Epidemiology, Biostatistics and Study Design Core. These cores will provide research support and technical training, as well as a venue for new collaborations and an entry point for new members. The Center will also foster scientific exchange through an Enrichment Program; the curriculum includes seminars featuring local and visiting scientists, an annual full-day retreat with the External and Internal Advisory and Boards, and a symposium with a rotating topic relevant to our theme of Systems in Musculoskeletal Biology and Medicine. Another vital component of the Center is its Pilot/Feasibility grant program. This provides seed money to junior investigators and to scientists new to musculoskeletal research. Finally, the Tool and Technology grant program will provide funds to Center members for the purpose of utilizing the outstanding specialized research services available outside the CCMBM at UCSF. Overall, the funding base for the CCMBM is robust, support from UCSF is strong, and opportunities for interactions within and outside the Center are numerous. The object of the Center is to make optimum use of all available resources to catalyze discovery in the basic biology of musculoskeletal disease.

拟议中的UCSF肌肉骨骼生物学和医学核心中心（CCMBM）将是一个 由114名基础和临床科学家组成的跨学科联盟，致力于了解生物学和 肌肉骨骼疾病的病理生理学。目标是激励和支持跨学科 UCSF现有的首要研究项目之间的合作，以加速转化 研究肌肉骨骼科学。从实验室到临床的转化研究面临的一个根本挑战是 需要在人类中验证小动物模型的发现。拟议的《全面禁止核试验条约》将克服这一问题 通过在研究疾病生物学的研究人员、开发先进的 研究工具和方法，分析大量临床数据档案的科学家， 积极治疗患者。UCSF CCMBM提出了三个核心：1）骨骼生物学和生物力学核心; 2)影像学核心;和3）流行病学、生物统计学和研究设计核心。这些核心将提供研究 支持和技术培训，以及新合作的场所和新成员的切入点。 该中心还将通过浓缩计划促进科学交流;课程包括研讨会 由当地和访问科学家参加，每年举行一次全天务虚会，由外部和内部咨询人员参加， 董事会，和一个与我们的主题有关的旋转主题的研讨会系统在肌肉骨骼生物学和 药该中心的另一个重要组成部分是其试点/可行性赠款计划。这提供了种子资金 给初级研究人员和刚接触肌肉骨骼研究的科学家。最后，工具和技术补助金 该计划将为中心成员提供资金，以利用优秀的专业研究成果 在UCSF的CCMBM之外提供的服务。总的来说，《全面禁止核试验条约》的供资基础是稳固的， 来自UCSF是强大的，并在中心内外的互动机会是众多的。对象 该中心的目标是充分利用所有可用资源，促进基础生物学的发现， 肌肉骨骼疾病