The mechanistic control of bone quality and joint crosstalk by osteocytes

骨细胞对骨质量和关节串扰的机械控制

• 批准号: 10605074
• 负责人: Tamara N Alliston
• 金额: $ 9.17万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-01 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10605074
• 关键词: Ablation; Acids; Address; Age; Aging; Agonist; Bone Density; Bone Matrix; Bone necrosis; Cells; Clinical; Communication; Coupled; Data; Defect; Degenerative polyarthritis; Development; Disease; Face; Fracture; Genes; Genetic Epistasis; Goals; Grant; Health; Histologic; Homeostasis; Human; Human Genome; Impairment; In Vitro; Joints; Knee joint; Link; Longevity; Metabolism; Mitochondria; Molecular; Mus; Musculoskeletal; Orthologous Gene; Osteocytes; Outcome; Parents; Pathway Analysis; Pattern; Peptide Hydrolases; Phenotype; Pilot Projects; Play; Population; Process; Property; Publishing; Regulation; Role; Signal Transduction; Specimen; Temporomandibular Joint; Testing; Work; age related; aged; aging population; arthropathies; biobank; bone; bone fragility; bone loss; bone mass; bone quality; cellular targeting; clinical development; cohort; cortical bone; differential expression; genome-wide; human data; improved; in vivo; joint destruction; loss of function; mitochondrial dysfunction; mouse model; novel; prevent; radiological imaging; response; skeletal; success; transcriptome sequencing

PROJECT SUMMARY Not applicable - no change from parent R01 grant.

项目总结