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Skeletal Biology and Biomechanics (SBB) Core

骨骼生物学和生物力学 (SBB) 核心

基本信息

批准号：
10460472
负责人：
Tamara N Alliston
金额：
$ 14.54万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-07-01 至 2024-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10460472
关键词：
Acceleration Address Adopted Adoption Aging Animal Model Applications Grants Area Big Data Biological Biology Biomechanics Cartilage Chondrocytes Clinical Investigator Communities Complement Consult Consultations Core Facility Critical Thinking Data Degenerative polyarthritis Development Digital Libraries Discipline Disease Educational process of instructing Educational workshop Event Experimental Designs Extracellular Matrix Female Fostering Genomics Goals Grant Growth Health Health Services Accessibility Human Length Location Manuscripts Mechanics Medicine Metabolism Methods Microscopy Musculoskeletal Musculoskeletal Diseases Musculoskeletal System National Institute of Arthritis and Musculoskeletal and Skin Diseases Neurosciences Neurosecretory Systems Organism Outcome Output Prevention Process Productivity Proteomics Protocols documentation Reagent Reproducibility Research Research Personnel Resources Role Sampling Scientist Services Site Skeletal Muscle Skeleton Surveys System Techniques Tissues Training Training Activity Training and Education Work X-Ray Computed Tomography aging population base bone bone mass cost effective digital epidemiologic data improved innovation interest member metabolomics microCT molecular scale mouse model prevent recruit single-cell RNA sequencing skeletal skeletal disorder skills success symposium tool

项目摘要

The UCSF Core Center for Musculoskeletal Biology and Medicine Skeletal Biology and Biomechanics (SBB) Core supports a large and robust research base of investigators. This diverse group of basic and clinical investigators has made major contributions to the understanding of musculoskeletal health and disease. However, the ongoing research efforts by these and other investigators remain insufficient to prevent the rapidly increasing occurrence of many acquired musculoskeletal diseases in our aging population. Thus, acceleration of research that advances the prevention and treatment of skeletal diseases is urgently needed. Solutions will require a more systems-based approach with integrated research strategies and investigator communities. To meet this challenge, the SBB Core facilitates musculoskeletal research at UCSF by providing integrated, cost- effective, and efficient access to rigorous musculoskeletal biology and biomechanics services. The SBB Core serves and cultivates the musculoskeletal research community across multiple campuses and disciplines by offering users seamless access to services, with Core sites at the two main campuses, easy digital conferencing, and events at multiple locations. The successful implementation of the SBB Core is anticipated to not only reduce research expenses and increase the output and quality of data, but also to produce robust in-depth analyses of samples and animal models through integration of different aspects of musculoskeletal biology and biomechanics. The Core’s adoption of sophisticated and powerful new services will streamline quantitative analyses of musculoskeletal tissues to complement and encourage the much-needed application of big data approaches to this field. Through training and education, the SBB Core will promote the entry of new investigators to the field and will foster a community of versatile musculoskeletal researchers with a broad set of skills and critical thinking.

加州大学旧金山分校肌肉骨骼生物学和医学核心中心骨骼生物学和生物力学 (SBB)Core支持庞大而强大的研究人员基础。这一多样化的基础和临床群体研究人员为了解肌肉骨骼健康和疾病做出了重大贡献。然而，这些和其他调查人员正在进行的研究努力仍然不足以防止迅速在我们老龄化的人口中，许多获得性肌肉骨骼疾病的发生率越来越高。因此，加速迫切需要更多的研究来推进骨骼疾病的预防和治疗。解决方案将需要更多以系统为基础的方法，并整合研究战略和研究人员社区。至面对这一挑战，SBB Core通过提供集成的、成本低廉的有效、高效地获得严格的肌肉骨骼生物学和生物力学服务。SBB核心为跨多个校区和学科的肌肉骨骼研究社区提供服务和培养通过两个主校区的核心站点，为用户提供无缝的服务访问、轻松的数字会议、以及多个地点的活动。SBB核心的成功实施预计不仅将减少研究费用，提高数据的产量和质量，但也能产生强大的深度通过整合肌肉骨骼生物学和生物医学的不同方面对样本和动物模型进行分析生物力学。核心采用复杂而强大的新服务将简化量化对肌肉骨骼组织进行分析，以补充和鼓励急需的大数据应用这一领域的研究方法。通过培训和教育，SBB核心将促进新的研究人员到现场，并将培养一个多才多艺的肌肉骨骼研究人员社区，拥有广泛的技能和批判性思维。