AAOS/ORS Tackling Joint Disease by Understanding Crosstalk between Cartilage and Bone Research Symposium

AAOS/ORS 通过了解软骨与骨之间的串扰来应对关节疾病研究研讨会

• 批准号: 9053709
• 负责人: Tamara N Alliston
• 金额: $ 1.5万
• 依托单位: AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-21 至 2016-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9053709
• 关键词: Academy; Address; Advanced Development; Affect; American; Area; Arthralgia; Arthritis; Award; Biological; Biological Process; Biology; Biomechanics; Bone necrosis; Cartilage; Chronic Childhood Arthritis; Clinical; Collaborations; Communities; Congresses; Coupled; Degenerative polyarthritis; Development; Disabled Persons; Discipline; Disease; Educational workshop; Engineering; Fostering; Funding Agency; Genomics; Goals; Gross National Product; Health; Histocompatibility Testing; Homeostasis; Immunology; Individual; Joints; Knowledge; Lead; Light; Longevity; Mechanics; Movement; Musculoskeletal; Nerve; ORALIT; Oral; Orthopedics; Outcome; Pain-Free; Patients; Population; Productivity; Publications; Publishing; Quality of life; Research; Research Personnel; Research Priority; Rheumatoid Arthritis; Scientist; Series; Societies; Solutions; Staging; Structure; Sum; Surgeon; Synovial Membrane; Tissues; Traumatic Arthropathy; United States; Update; abstracting; arthropathies; base; bone; clinical care; clinically significant; cohort; design; disability; economic impact; improved; innovation; joint function; knowledge base; meetings; microbiome; novel; posters; prevent; public health relevance; symposium

 DESCRIPTION (provided by applicant): The healthy joint seamlessly integrates the mechanical and biological functions of multiple tissues, including cartilage, bone, synovium, nerve, vasculature, and others, to support smooth, pain-free movement. Surprisingly little is known about the mechanisms that support this integration, or the mechanisms that disrupt it in joint disease. Understanding these mechanisms is central to maintaining joint health and treating joint disease, the leading cause of disability in the United States. Joint diseases such a osteoarthritis, osteonecrosis, juvenile arthritis, and post-traumatic arthritis disable individuals across the lifespan affecting over 46 million Americans, including more than half of the population over 65. While advances in the study of individual joint tissues have shed light on the mechanisms of joint disease, more research is needed to elucidate the mechanisms by which these tissues interact, and the local and systemic factors responsible for this crosstalk. Therefore, the American Academy of Orthopaedic Surgeons (AAOS) selected Tackling Joint Disease by Understanding Crosstalk between Cartilage and Bone as the topic for the 2016 AAOS Research Symposium. The exceptional burden of joint disease motivates a focused, interdisciplinary symposium designed to advance the development of better clinical solutions. This symposium takes an innovative approach to overcome the boundaries in disciplinary or scientific expertise that limit progress in understanding the integration of individual tissues in he joint. The primary objective of the symposium is to engage clinicians, engineers, and biologists to share emerging concepts from each discipline on crosstalk among bone, cartilage, systemic factors, and other tissues in joint health and disease across the lifespan. The structure of the meeting supports this goal, with a single-platform format that allows the entire group to consider together and discuss seven topics that were selected to highlight advances from individual fields within the context of joint crosstalk. All sessions at this 2.5-day meeting feature invited presentations by scientific leaders and pioneering junior investigators who are applying new ideas and approaches to understand joint function. Each session includes a 30 minute structured discussion to identify the leading edge of the field, determine gaps in knowledge, and establish new research priorities. Fifteen New Investigator Awards support the engagement of diverse early stage investigators as oral or poster presenters. In addition to publishing the proceedings of the symposium, outcomes include workshops at annual meetings of musculoskeletal research societies, a webinar, and inclusion of updated research priorities in the AAOS Unified Orthopaedic Research Agenda, which communicates musculoskeletal research needs to funding agencies, Congress, and the public. Given the urgent demand for improved clinical solutions, and the recent advances in bone and cartilage research, this symposium will stimulate the dialogue to accelerate research on crosstalk among tissues in the joint, to understand and ultimately treat degenerative joint disease.

 描述（由申请人提供）：健康的关节无缝地整合了多种组织的机械和生物功能，包括软骨、骨骼、滑膜、神经、脉管系统等，以支持平滑、无痛的运动。令人惊讶的是，人们对支持这种整合的机制或在关节疾病中破坏这种整合的机制知之甚少。了解这些机制对于维持关节健康和治疗关节疾病至关重要，关节疾病是美国残疾的主要原因。骨关节炎、骨坏死、幼年关节炎和创伤后关节炎等关节疾病会导致个体残疾 影响着超过 4600 万美国人的一生，其中包括超过一半的 65 岁以上人口。虽然个体关节组织研究的进展揭示了关节疾病的机制，但需要更多的研究来阐明这些组织相互作用的机制，以及造成这种串扰的局部和全身因素。因此，美国骨科医师学会（AAOS）选择“通过了解软骨与骨之间的串扰来应对关节疾病”作为2016年AAOS研究研讨会的主题。关节疾病的特殊负担催生了一次重点突出的跨学科研讨会，旨在推动更好的临床解决方案的开发。本次研讨会采用创新方法来克服学科或科学专业知识的界限，这些界限限制了理解关节中单个组织整合的进展。研讨会的主要目标是让临床医生、工程师和生物学家分享各个学科关于骨骼、软骨、系统因素和其他组织之间的串扰在整个生命周期中关节健康和疾病的新兴概念。会议的结构支持这一目标，采用单一平台的形式，使整个小组能够共同考虑和讨论七个主题，这些主题被选择来突出联合串扰背景下各个领域的进展。这次为期 2.5 天的会议的所有会议均邀请科学领袖和初级研究人员进行特邀演讲，他们正在应用新的想法和方法来理解关节功能。每场会议包括 30 分钟的结构化讨论，以确定该领域的前沿、确定知识差距并确定新的研究重点。十五个新研究者奖支持不同的早期研究人员作为口头或海报展示者的参与。除了出版研讨会论文集外，成果还包括在肌肉骨骼研究学会年会上举办研讨会、网络研讨会，以及将最新的研究重点纳入 AAOS 统一骨科研究议程，该议程向资助机构、国会和公众传达肌肉骨骼研究需求。鉴于对改进临床解决方案的迫切需求，以及骨和软骨研究的最新进展，本次研讨会将激发对话，加速关节组织间串扰的研究，以了解并最终治疗退行性关节疾病。