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Core Center for Musculoskeletal Biology and Medicine (Overall Application)

肌肉骨骼生物学与医学核心中心（整体应用）

基本信息

批准号：
10642787
负责人：
Tamara N Alliston
金额：
$ 77.42万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-07-01 至 2024-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10642787
关键词：
Acceleration Acids Animal Model Applications Grants Archives Area Back Basic Science Biology Biomechanics Biometry Calcium-Sensing Receptors Clinical Clinical Data Clinical Sciences Collaborations Communication Country Dedications Degenerative polyarthritis Diagnosis Digital Libraries Discipline Disease Education Educational Curriculum Endocrine Epidemiology Etiology Experimental Designs Fostering Fracture Functional disorder Funding Goals Grant Health Histologic Human Image Infrastructure Insulin-Like Growth Factor I Investigation Knowledge Laboratories Leadership Locomotion Manuscripts Medical center Medicine Metabolic Bone Diseases Methods Mission Musculoskeletal Musculoskeletal Diseases National Institute of Arthritis, and Musculoskeletal, and Skin Diseases Orthopedic Surgery Orthopedics Osteoporosis PTH gene Patients Productivity Protocols documentation Publishing Reagent Recording of previous events Reporting Reproducibility Research Research Design Research Personnel Research Support Resources Role Rotation Science Scientist Services Site Specialist System Technology Tissue Sample Tissues Training Transcend Translating Translational Research United States National Institutes of Health Visit base bench-to-bedside translation biomechanical test disease phenotype experience imaging modality innovation interdisciplinary collaboration longitudinal database mechanical load member men musculoskeletal imaging non-invasive imaging osteoporosis with pathological fracture pre-clinical programs quantitative imaging reconstruction skeletal symposium synergism theories tool

项目摘要

The proposed UCSF Core Center for Musculoskeletal Biology and Medicine (CCMBM) will be an interdisciplinary consortium of 114 basic and clinical scientists dedicated to understanding the biology and pathophysiology of musculoskeletal disease. The goal is to stimulate and support transdisciplinary collaborations amongst existing, premier research programs at UCSF in order to accelerate translational research in musculoskeletal science. A fundamental challenge for bench-to-bedside translational research is the need to validate in humans the findings from small animal models. The proposed CCMBM will overcome this obstacle by forming a linkage between researchers who study disease biology, experts who develop advanced investigational tools and methods, scientists who analyze vast archives of clinical data, and practitioners who actively treat patients. The UCSF CCMBM proposes three cores: 1) Skeletal Biology and Biomechanics Core; 2) Imaging Core; and 3) Epidemiology, Biostatistics and Study Design Core. These cores will provide research support and technical training, as well as a venue for new collaborations and an entry point for new members. The Center will also foster scientific exchange through an Enrichment Program; the curriculum includes seminars featuring local and visiting scientists, an annual full-day retreat with the External and Internal Advisory and Boards, and a symposium with a rotating topic relevant to our theme of Systems in Musculoskeletal Biology and Medicine. Another vital component of the Center is its Pilot/Feasibility grant program. This provides seed money to junior investigators and to scientists new to musculoskeletal research. Finally, the Tool and Technology grant program will provide funds to Center members for the purpose of utilizing the outstanding specialized research services available outside the CCMBM at UCSF. Overall, the funding base for the CCMBM is robust, support from UCSF is strong, and opportunities for interactions within and outside the Center are numerous. The object of the Center is to make optimum use of all available resources to catalyze discovery in the basic biology of musculoskeletal disease.

拟议的UCSF肌肉骨骼生物学和医学核心中心（CCMBM）将是一个

项目成果

期刊论文数量（7）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

The Prevalence of Bullying Among Pediatric Orthopaedic Patients.

儿科骨科患者中欺凌行为的发生率。

DOI：
10.1097/bpo.0000000000001911
发表时间：
2021
期刊：
Journal of pediatric orthopedics
影响因子：
0
作者：
Carrillo,LauraA;Sabatini,ColeenS;Brar,RavinderK;Jagodzinski,JasonE;Sabharwal,Sanjeev;Delgado,Eliana;Livingston,KristinS
通讯作者：
Livingston,KristinS

Longitudinal Relationship Between Physical Activity and Joint Space Narrowing: Forty-Eight-Month Follow-Up Data From the Osteoarthritis Initiative.