UCSF Musculoskeletal Training Program

加州大学旧金山分校肌肉骨骼训练计划

• 批准号: 10625232
• 负责人: Tamara N Alliston
• 金额: $ 24.26万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-01 至 2028-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10625232
• 关键词: Musculoskeletal; Training Programs

PROJECT SUMMARY The overall goal of the UCSF Musculoskeletal (MSK) Training Program is to prepare Ph.D. scientists and M.D. or M.D./Ph.D. residents and fellows for a lifetime of scholarly pursuits that lead to in-depth understanding and improved care for patients with MSK diseases. We are confident that our proposed training program will accomplish this goal. Drawing on the solid mentorship skills of 35 nationally renowned and highly collaborative faculty with primary appointments in 10 academic and clinical departments, the UCSF MSK Training Program provides rigorous research training in basic and clinical/translational sciences important to the study of MSK diseases. These 35 participating faculty members bring multi-disciplined expertise that reflects areas of rapidly expanding research development such as stem cells, neurobiology, tissue regeneration, molecular physiology, and artificial intelligence. A vital aspect of the program is to focus exclusively on preparing postdoctoral trainees for independent research careers. The program proposes three slots for postdoctoral trainees, including two slots for Ph.D. postdoctoral fellows (research training duration of two years) and one slot for physician trainees from our research-track residency program in Orthopaedic Surgery (research training duration of one year). The central component of the training experience is direct research in the basic laboratory or clinical/translational research group of a primary research mentor. The training experience fuses this scientific training with sustained, individualized, and goal-oriented mentorship that guides trainees along the pathway to gaining their competitive research funding. The program includes formal coursework in ethics, rigor and reproducibility, statistical analysis, and grant-writing. It will also emphasize basic and clinical/translational science education by drawing on significant curricular activities designed explicitly for MSK science; innovative research experiences with an emphasis on scientific rigor and translation; individualized development plans that utilize evidence-based approaches for career planning; numerous exposures to state-of-the-art methods and techniques through weekly grand rounds and invited lectures, monthly research-in-progress seminars, journal clubs, and an annual retreat; and scientific communication through formal expectations of publications and presentations at national meetings. These activities capitalize on the programmatic and scientific infrastructure created by several existing MSK- related centers and institutes with UCSF-wide participation and influence. Overall, the training enabled by this program will attract and prepare junior scientists with the goal of understanding the mechanistic basis of MSK diseases, finding new therapies for these diseases, and ensuring that scientific discoveries lead to advances in public health in an equitable and cost-effective manner. In doing so, the program will ensure that a cadre of young scientists will pursue academic careers in MSK research and advance the field in fundamental ways.

项目摘要 UCSF肌肉骨骼（MSK）培训计划的总体目标是准备博士学位。科学家和医学博士 或医学博士/博士居民和研究员一生的学术追求，导致深入了解， 改善MSK疾病患者的护理。我们相信，我们提出的培训计划将 实现这一目标。利用35个全国知名和高度合作的坚实的指导技能 在10个学术和临床部门的主要任命教师，UCSF MSK培训计划 提供对MSK研究重要的基础和临床/转化科学的严格研究培训 疾病这35名参与教师带来了多学科的专业知识，反映了快速发展的领域， 扩大研究开发，如干细胞，神经生物学，组织再生，分子生理学， 和人工智能该计划的一个重要方面是专注于培养博士后学员 独立研究的职业。该计划为博士后培训生提供了三个名额，其中包括两个 博士学位博士后研究员（研究培训期为两年）和一个医生实习生名额 从我们的研究跟踪住院医师计划在矫形外科（研究培训为期一年）。的 培训经验的中心组成部分是在基础实验室或临床/翻译的直接研究 一个主要研究导师的研究小组。培训经验将这种科学的培训与持续的， 个性化的，以目标为导向的指导，引导学员沿着道路，以获得他们的竞争力 科研经费该计划包括道德，严谨性和可重复性，统计分析， 和赠款写作。它还将强调基础和临床/转化科学教育， 明确为MSK科学设计的重要课程活动;创新的研究经验， 强调科学的严谨性和翻译;个性化的发展计划，利用基于证据的 职业规划的方法;通过每周一次的培训， 大轮和邀请讲座，每月的研究进展研讨会，期刊俱乐部和年度务虚会; 通过对出版物的正式期望和在国家会议上的介绍，促进科学交流。 这些活动利用了现有的几个MSK创建的方案和科学基础设施， 相关中心和研究所与UCSF广泛的参与和影响。总的来说，通过这种方式， 该计划将吸引和准备初级科学家的目标是了解MSK的机械基础 疾病，为这些疾病寻找新的疗法，并确保科学发现导致进步， 以公平和具有成本效益的方式促进公共卫生。在这样做的时候，该方案将确保一个干部， 年轻的科学家将在MSK研究中追求学术生涯，并从根本上推动该领域的发展。