UCSF Musculoskeletal Training Program

加州大学旧金山分校肌肉骨骼训练计划

• 批准号: 10625232
• 负责人: Tamara N Alliston
• 金额: $ 24.26万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-01 至 2028-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10625232
• 关键词: Musculoskeletal; Training Programs

PROJECT SUMMARY The overall goal of the UCSF Musculoskeletal (MSK) Training Program is to prepare Ph.D. scientists and M.D. or M.D./Ph.D. residents and fellows for a lifetime of scholarly pursuits that lead to in-depth understanding and improved care for patients with MSK diseases. We are confident that our proposed training program will accomplish this goal. Drawing on the solid mentorship skills of 35 nationally renowned and highly collaborative faculty with primary appointments in 10 academic and clinical departments, the UCSF MSK Training Program provides rigorous research training in basic and clinical/translational sciences important to the study of MSK diseases. These 35 participating faculty members bring multi-disciplined expertise that reflects areas of rapidly expanding research development such as stem cells, neurobiology, tissue regeneration, molecular physiology, and artificial intelligence. A vital aspect of the program is to focus exclusively on preparing postdoctoral trainees for independent research careers. The program proposes three slots for postdoctoral trainees, including two slots for Ph.D. postdoctoral fellows (research training duration of two years) and one slot for physician trainees from our research-track residency program in Orthopaedic Surgery (research training duration of one year). The central component of the training experience is direct research in the basic laboratory or clinical/translational research group of a primary research mentor. The training experience fuses this scientific training with sustained, individualized, and goal-oriented mentorship that guides trainees along the pathway to gaining their competitive research funding. The program includes formal coursework in ethics, rigor and reproducibility, statistical analysis, and grant-writing. It will also emphasize basic and clinical/translational science education by drawing on significant curricular activities designed explicitly for MSK science; innovative research experiences with an emphasis on scientific rigor and translation; individualized development plans that utilize evidence-based approaches for career planning; numerous exposures to state-of-the-art methods and techniques through weekly grand rounds and invited lectures, monthly research-in-progress seminars, journal clubs, and an annual retreat; and scientific communication through formal expectations of publications and presentations at national meetings. These activities capitalize on the programmatic and scientific infrastructure created by several existing MSK- related centers and institutes with UCSF-wide participation and influence. Overall, the training enabled by this program will attract and prepare junior scientists with the goal of understanding the mechanistic basis of MSK diseases, finding new therapies for these diseases, and ensuring that scientific discoveries lead to advances in public health in an equitable and cost-effective manner. In doing so, the program will ensure that a cadre of young scientists will pursue academic careers in MSK research and advance the field in fundamental ways.

项目总结 加州大学旧金山分校肌肉骨骼(MSK)培训计划的总体目标是培养博士、科学家和医学博士。 或医学博士/博士住院医生和研究员的终身学术追求，导致深入了解和 改善对MSK疾病患者的护理。我们相信，我们提议的培训计划将 实现这一目标。凭借35位全国知名且高度合作的导师的扎实指导技能 加州大学旧金山分校MSK培训计划10个学术和临床部门的初级教职员工 提供对MSK研究重要的基础和临床/翻译科学方面的严格研究培训 疾病。这35名参与的教职员工带来了多学科的专业知识，反映了迅速 拓展干细胞、神经生物学、组织再生、分子生理学、 和人工智能。该计划的一个重要方面是专注于培养博士后实习生 从事独立研究的职业。该计划为博士后实习生提供了三个名额，其中包括两个 博士后名额(研究性培训为期两年)和一个内科实习生名额 来自我们的骨科外科研究跟踪住院医师计划(研究培训为期一年)。这个 培训经验的核心部分是在基础实验室或临床/转化性实验室进行直接研究 一位主要研究导师组成的研究小组。训练经验将这种科学训练与持续的、 个性化、以目标为导向的指导，引导学员在获得竞争力的道路上前进 研究经费。该计划包括伦理学、严谨性和再现性、统计分析、 以及拨款申请。它还将强调基础和临床/翻译科学教育，借鉴 专门为MSK科学设计的重要课程活动；创新的研究经验 强调科学严谨和翻译；利用循证的个性化发展计划 职业生涯规划的方法；通过每周接触最先进的方法和技术 大型讲座和特邀讲座、每月进行中的研究研讨会、期刊俱乐部和年度静修； 以及通过对出版物的正式期望和在国家会议上的介绍进行科学交流。 这些活动利用了几个现有的MSK创建的方案和科学基础设施- 具有加州大学旧金山分校广泛参与和影响的相关中心和机构。总体而言，这一点带来的培训 该计划将吸引和培养初级科学家，目标是了解MSK的机制基础 为这些疾病寻找新的治疗方法，并确保科学发现导致在 以公平和具有成本效益的方式促进公共卫生。在这样做的过程中，该计划将确保一支 年轻的科学家将在MSK研究中追求学术生涯，并在根本上推进该领域的发展。