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CARDIAC PEPTIDES IN THE CONTROL OF BLOOD VOLUME

强心肽控制血容量

基本信息

批准号：
2221714
负责人：
JOHN R DIETZ
金额：
$ 11.05万
依托单位：
UNIVERSITY OF SOUTH FLORIDA
依托单位国家：
美国
项目类别：
财政年份：
1991
资助国家：
美国
起止时间：
1991-05-01 至 1995-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/2221714
关键词：
angiotensin /renin /aldosterone hypertension antihypertensive agents atrial natriuretic peptide blood volume coronary disorder electrolyte balance hormone regulation /control mechanism isolation perfusion kidney circulation kidney function laboratory rat renin salt intake stretch receptors stroke

项目摘要

DESCRIPTION: (Adapted from the Abstract) Over a period of many years it has become apparent that the regulation of arterial pressure is intimately linked to body salt and water balance. Recently, it has been shown that the atria contain a potent natriuretic and blood pressure lowering substance which has been termed the atrial natriuretic factor (ANF). The long-term goals of this project are to obtain a better understanding of the role of ANF and other potential cardiac hormones in the regulation of kidney function, blood volume and blood pressure. Recent evidence suggests that in addition to ANF, other peptides formed from the pro-ANF molecule circulate in plasma. Specifically, pro-ANF (31-67) is present in plasma in higher concentrations than ANF and may have physiological effects similar to ANF. The goals of this project are: 1) to establish normal baseline values for pro-ANF (31-67) in rats on normal, low and high NaCl intakes, 2) to determine the effect of 5, 10 or 20% blood volume expansions on plasma pro-ANF (31-67) in anesthetized rats and compare these changes to changes in ANF, 3) to compare the effects of similar infused doses of ANF and pro-ANF (31-67) on renal function, plasma renin activity and blood pressure, 4) to examine the effect of pro-ANF (31-67) on renal flow, GFR, sodium chloride excretion, water excretion and renin secretion in the isolated perfused kidney, 5) to compare the secretion of pro-ANF (1-98), pro-ANF (31-67) and ANF (99-126) from isolated atria in response to: a) changes in atrial stretch and b) atrial pacing and 6) to test for a short-loop negative feedback effect of ANF or pro-ANF (31-67) on their own production by measuring pro-ANF (1-98) secretion as an end point in the isolated atria. Although numerous studies have focused on ANF, it is apparent that more information is needed on the relative importance the other portions of the pro-ANF molecule in the control of renal function and blood volume. Recent evidence suggests that these other atrial peptides, particularly pro-ANF (31-67), may have an important physiological role.

描述：（改编自摘要）经过多年的发展，它

项目成果

期刊论文数量（14）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Atrial natriuretic factor prohormone peptides are present in a variety of tissues.

心房钠尿因子激素原肽存在于多种组织中。

DOI：
10.1016/0196-9781(92)90158-y
发表时间：
1992
期刊：
Peptides
影响因子：
3
作者：
Vesely,DL;Palmer,PA;Giordano,AT
通讯作者：
Giordano,AT

Three peptides from the atrial natriuretic factor prohormone amino terminus lower blood pressure and produce diuresis, natriuresis, and/or kaliuresis in humans.

来自心房钠尿因子激素原氨基末端的三种肽可降低人体血压并产生利尿、尿钠排泄和/或排钾作用。

DOI：
10.1161/01.cir.90.3.1129
发表时间：
1994
期刊：
Circulation
影响因子：
37.8
作者：
Vesely,DL;Douglass,MA;Dietz,JR;GowerJr,WR;McCormick,MT;Rodriguez-Paz,G;Schocken,DD
通讯作者：
Schocken,DD

Immunocytochemical localization of proANF 1-30, proANF 31-67 and atrial natriuretic factor in the kidney.