Mechanistic and translational studies targeting kidney inflammation and fibrosis.

针对肾脏炎症和纤维化的机制和转化研究。

• 批准号: nhmrc : 1058175
• 负责人: A/Pr David Nikolic-Paterson
• 金额: $ 46.49万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/mechanistic-translational-studies-inflammation-fibrosis/454654
• 关键词: Mechanistic; translational; studies; targeting; kidney

The progression of kidney disease to end-stage renal failure requires support by dialysis or kidney transplantation, leading to reduced quality of life, loss of productivity, and the huge cost of renal replacement therapy in Australia ($1 billion in 2010). This research program focuses on two areas; advancing our understanding of the basic mechanisms of disease pathogenesis, and working with commercial partners to translate my current research effort towards new therapies for kidney disease.

肾脏疾病进展为终末期肾衰竭需要透析或肾移植的支持，导致生活质量下降，生产力下降，以及澳大利亚肾脏替代治疗的巨额费用（2010年为10亿美元）。该研究计划侧重于两个领域：推进我们对疾病发病机制的基本机制的理解，并与商业合作伙伴合作，将我目前的研究成果转化为肾脏疾病的新疗法。