Mineralocortioid Receptor-Mediated Injury in Progressive Kidney Disease
Mineralocortioid Receptor-Mediated Injury in Progressive Kidney Disease
批准号:
nhmrc : GNT1102882
负责人:
A/Pr David Nikolic-Paterson
金额:
$70.7万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2016
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2016-01-01 至 --
中文摘要
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英文摘要
Diabetes is the major cause of kidney failure. Activation of a hormone receptor (the mineralocorticoid receptor-MR) can promote kidney injury. Current drugs blocking MR can suppress diabetic kidney disease but are limited by their poor specificity and harmful side effects. Our study will help improve strategies for blocking MR by identifying the cell types responsible for MR-mediated injury and by examining whether a new class of drug targeting MR is a superior therapy to current MR inhibitors.
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依托单位:
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批准号:nhmrc : GNT1122073
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项目类别:Project Grants
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财政年份:2017
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负责人:A/Pr David Nikolic-Paterson
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依托单位:
Mineralocortioid Receptor-Mediated Injury in Progressive Kidney Disease
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批准号:nhmrc : 1102882
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依托单位:
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依托单位:
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依托单位:
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依托单位:
Mechanistic and translational studies targeting kidney inflammation and fibrosis.
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项目类别:Research Fellowships
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依托单位:
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依托单位:
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依托单位:
New roles for the spleen tyrosine kinase in antibody-independent renal injury.
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财政年份:2011
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依托单位:
Distinct pathogenic roles for JNK signalling in glomerular and interstitial injury in kidney disease.
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财政年份:2011
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负责人:A/Pr David Nikolic-Paterson
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依托单位:
Resolvin E1 is a novel anti-inflammatory and anti-fibrotic lipid mediator for the treatment of chronic kidney disease.
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批准号:nhmrc : 606400
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项目类别:NHMRC Project Grants
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资助金额:$34.62万
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财政年份:2010
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负责人:A/Pr David Nikolic-Paterson
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依托单位:
Selective targeting of acute renal injury by inhibition of the receptor tyrosine kinase, c-fms.
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项目类别:NHMRC Project Grants
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资助金额:$29.54万
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财政年份:2010
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负责人:A/Pr David Nikolic-Paterson
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依托单位:
TAK1 - a novel regulator of renal inflammation and fibrosis.
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批准号:nhmrc : 494822
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项目类别:NHMRC Project Grants
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资助金额:$35.85万
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财政年份:2008
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负责人:A/Pr David Nikolic-Paterson
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依托单位:
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批准号:nhmrc : 494823
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资助金额:$34.65万
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依托单位:
Lefty - a novel anti-fibrotic molecule for the treatment of kidney disease
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项目类别:NHMRC Project Grants
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资助金额:$28.4万
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负责人:A/Pr David Nikolic-Paterson
-
依托单位:
Role of JNK and p38 MAPK signalling in diabetic nephropathy
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批准号:nhmrc : 338517
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项目类别:NHMRC Project Grants
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资助金额:$30.31万
-
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-
负责人:A/Pr David Nikolic-Paterson
-
依托单位:
国内基金
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