Defining the central role of podocyte depletion in the development, progression and management of glomerular disease

定义足细胞耗竭在肾小球疾病的发生、进展和治疗中的核心作用

• 批准号: nhmrc : 1121793
• 负责人: A/Pr David Nikolic-Paterson
• 金额: $ 47.17万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/defining-central-role-glomerular-disease/946810
• 关键词: Defining; central; role; podocyte; depletion

Podocytes are key cellular components of the kidney’s filtration barrier. Podocyte depletion (cell loss or injury) is a key event in most forms of kidney disease. We will investigate interactions between podocyte depletion and two major risk factors for kidney disease (diabetes and hypertension), assess whether podocyte depletion influences therapeutic outcomes, and commence efforts to develop podocyte-specific therapies.

足细胞是肾脏滤过屏障的关键细胞成分。足细胞耗竭（细胞损失或损伤）是大多数肾脏疾病的关键事件。我们将研究足细胞消耗与肾脏疾病的两个主要危险因素（糖尿病和高血压）之间的相互作用，评估足细胞消耗是否影响治疗结果，并开始努力开发足细胞特异性治疗方法。