TAK1 - a novel regulator of renal inflammation and fibrosis.
TAK1 - a novel regulator of renal inflammation and fibrosis.
批准号:
nhmrc : 494822
负责人:
A/Pr David Nikolic-Paterson
金额:
$35.85万
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2008
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2008-01-01 至 2010-12-31
中文摘要
点击翻译按钮获取中文摘要
英文摘要
Renal failure is a major health problem in our community. Recent in vitro studies have identified a protein that plays a critical role in the induction of inflammation and fibrosis - processes central to the progression of kidney disease. This project will use a genetic-based approach to determine if this regulator plays a critical role in the pathogenesis of experimental kidney disease. If successful, these studies will identify a new therapeutic target for the treatment of kidney disease.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
TGF-beta/Smad signalling in macrophage-mediated renal fibrosis.
-
批准号:nhmrc : 1122073
-
项目类别:Project Grants
-
资助金额:$46.66万
-
财政年份:2017
-
负责人:A/Pr David Nikolic-Paterson
-
依托单位:
Defining the central role of podocyte depletion in the development, progression and management of glomerular disease
-
批准号:nhmrc : GNT1121793
-
项目类别:Project Grants
-
资助金额:$69.09万
-
财政年份:2017
-
负责人:A/Pr David Nikolic-Paterson
-
依托单位:
Defining the central role of podocyte depletion in the development, progression and management of glomerular disease
-
批准号:nhmrc : 1121793
-
项目类别:Project Grants
-
资助金额:$47.17万
-
财政年份:2017
-
负责人:A/Pr David Nikolic-Paterson
-
依托单位:
TGF-beta/Smad signalling in macrophage-mediated renal fibrosis.
-
批准号:nhmrc : GNT1122073
-
项目类别:Project Grants
-
资助金额:$68.37万
-
财政年份:2017
-
负责人:A/Pr David Nikolic-Paterson
-
依托单位:
Mineralocortioid Receptor-Mediated Injury in Progressive Kidney Disease
-
批准号:nhmrc : GNT1102882
-
项目类别:Project Grants
-
资助金额:$70.7万
-
财政年份:2016
-
负责人:A/Pr David Nikolic-Paterson
-
依托单位:
Mineralocortioid Receptor-Mediated Injury in Progressive Kidney Disease
-
批准号:nhmrc : 1102882
-
项目类别:Project Grants
-
资助金额:$48.47万
-
财政年份:2016
-
负责人:A/Pr David Nikolic-Paterson
-
依托单位:
Modulating Inflammatory and Fibrogenic Pathways in Kidney Disease using a novel antagonist of Protease-Activated-Receptor-2
-
批准号:nhmrc : 1083131
-
项目类别:Project Grants
-
资助金额:$39.89万
-
财政年份:2015
-
负责人:A/Pr David Nikolic-Paterson
-
依托单位:
Modulating Inflammatory and Fibrogenic Pathways in Kidney Disease using a novel antagonist of Protease-Activated-Receptor-2
-
批准号:nhmrc : GNT1083131
-
项目类别:Project Grants
-
资助金额:$38.75万
-
财政年份:2015
-
负责人:A/Pr David Nikolic-Paterson
-
依托单位:
Spleen tyrosine kinase (Syk) as a therapeutic target in antibody-dependent transplant rejection.
-
批准号:nhmrc : 1057565
-
项目类别:Project Grants
-
资助金额:$41.74万
-
财政年份:2014
-
负责人:A/Pr David Nikolic-Paterson
-
依托单位:
New strategies for the treatment of kidney disease.
-
批准号:nhmrc : GNT1058175
-
项目类别:Research Fellowships
-
资助金额:$66.45万
-
财政年份:2014
-
负责人:A/Pr David Nikolic-Paterson
-
依托单位:
Mechanistic and translational studies targeting kidney inflammation and fibrosis.
-
批准号:nhmrc : 1058175
-
项目类别:Research Fellowships
-
资助金额:$46.49万
-
财政年份:2014
-
负责人:A/Pr David Nikolic-Paterson
-
依托单位:
Smad3 acetylation modulates organ fibrosis
-
批准号:nhmrc : 1057581
-
项目类别:Project Grants
-
资助金额:$45.55万
-
财政年份:2014
-
负责人:A/Pr David Nikolic-Paterson
-
依托单位:
Apoptosis signal-regulating kinase 1 (ASK1) is a major pathway of stress-induced renal injury in different types of progressive kidney disease.
-
批准号:nhmrc : 1044289
-
项目类别:Project Grants
-
资助金额:$45.27万
-
财政年份:2013
-
负责人:A/Pr David Nikolic-Paterson
-
依托单位:
New roles for the spleen tyrosine kinase in antibody-independent renal injury.
-
批准号:nhmrc : 1002079
-
项目类别:NHMRC Project Grants
-
资助金额:$38.33万
-
财政年份:2011
-
负责人:A/Pr David Nikolic-Paterson
-
依托单位:
Distinct pathogenic roles for JNK signalling in glomerular and interstitial injury in kidney disease.
-
批准号:nhmrc : 1006348
-
项目类别:NHMRC Project Grants
-
资助金额:$37.07万
-
财政年份:2011
-
负责人:A/Pr David Nikolic-Paterson
-
依托单位:
Resolvin E1 is a novel anti-inflammatory and anti-fibrotic lipid mediator for the treatment of chronic kidney disease.
-
批准号:nhmrc : 606400
-
项目类别:NHMRC Project Grants
-
资助金额:$34.62万
-
财政年份:2010
-
负责人:A/Pr David Nikolic-Paterson
-
依托单位:
Selective targeting of acute renal injury by inhibition of the receptor tyrosine kinase, c-fms.
-
批准号:nhmrc : 606685
-
项目类别:NHMRC Project Grants
-
资助金额:$29.54万
-
财政年份:2010
-
负责人:A/Pr David Nikolic-Paterson
-
依托单位:
Therapeutic targetting of MIF in type 2 diabetes
-
批准号:nhmrc : 494823
-
项目类别:NHMRC Project Grants
-
资助金额:$34.65万
-
财政年份:2008
-
负责人:A/Pr David Nikolic-Paterson
-
依托单位:
Lefty - a novel anti-fibrotic molecule for the treatment of kidney disease
-
批准号:nhmrc : 388902
-
项目类别:NHMRC Project Grants
-
资助金额:$28.4万
-
财政年份:2007
-
负责人:A/Pr David Nikolic-Paterson
-
依托单位:
Role of JNK and p38 MAPK signalling in diabetic nephropathy
-
批准号:nhmrc : 338517
-
项目类别:NHMRC Project Grants
-
资助金额:$30.31万
-
财政年份:2005
-
负责人:A/Pr David Nikolic-Paterson
-
依托单位:
国内基金
海外基金
登录
查看更多内容
Novel-miR-1134调控LHCGR的表达介导拟
穴青蟹卵巢发育的机制研究
-
批准号:
-
项目类别:省市级项目
-
资助金额:10.0万元
-
批准年份:2025
-
负责人:崔文晓
-
依托单位:
novel-miR75靶向OPR2,CA2和STK基因调控人参真菌胁迫响应的分子机制研究
-
批准号:82304677
-
项目类别:青年科学基金项目
-
资助金额:30.00万元
-
批准年份:2023
-
负责人:边兴博
-
依托单位:
海南广藿香Novel17-GSO1响应p-HBA调控连作障碍的分子机制
-
批准号:82304658
-
项目类别:青年科学基金项目
-
资助金额:30万元
-
批准年份:2023
-
负责人:刘亚
-
依托单位:
白术多糖通过novel-mir2双靶向TRADD/MLKL缓解免疫抑制雏鹅的胸腺程序性坏死
-
批准号:32102747
-
项目类别:青年科学基金项目(C类)
-
资助金额:30.0万元
-
批准年份:2021
-
负责人:李婉雁
-
依托单位:
novel_circ_001042/miR-298-5p/Capn1轴调节线粒体能量代谢在先天性肛门直肠畸形发生中的作用机制研究
-
批准号:--
-
项目类别:面上项目
-
资助金额:55万元
-
批准年份:2021
-
负责人:唐晓冰
-
依托单位:
novel-miR-59靶向HMGAs介导儿童早衰症细胞衰老的作用及机制研究
-
批准号:--
-
项目类别:面上项目
-
资助金额:58万元
-
批准年份:2021
-
负责人:张瑜
-
依托单位:
novel_circ_008138/rno-miR-374-3p/SFRP4调控Wnt信号通路参与先天性肛门直肠畸形发生的分子机制研究
-
批准号:82070530
-
项目类别:面上项目
-
资助金额:55.0万元
-
批准年份:2020
-
负责人:白玉作
-
依托单位:
miRNA-novel-272通过靶向半乳糖凝集素3调控牙鲆肠道上皮细胞炎症反应的机制研究
-
批准号:32002421
-
项目类别:青年科学基金项目
-
资助金额:24.0万元
-
批准年份:2020
-
负责人:修云吉
-
依托单位:
m6A修饰介导的lncRNA WEE2-AS1转录后novel-pri-miRNA剪切机制在胶质瘤恶性进展中的作用研究
-
批准号:82072775
-
项目类别:面上项目
-
资助金额:55.0万元
-
批准年份:2020
-
负责人:薛皓
-
依托单位:
miRNA/novel_167靶向抑制Dmrt1的表达在红鳍东方鲀性别分化过程中的功能研究
-
批准号:31902347
-
项目类别:青年科学基金项目
-
资助金额:25.0万元
-
批准年份:2019
-
负责人:闫红伟
-
依托单位: