Distinct pathogenic roles for JNK signalling in glomerular and interstitial injury in kidney disease.
Distinct pathogenic roles for JNK signalling in glomerular and interstitial injury in kidney disease.
批准号:
nhmrc : 1006348
负责人:
A/Pr David Nikolic-Paterson
金额:
$37.07万
依托单位:
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2011
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2011-01-01 至 2013-12-31
中文摘要
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英文摘要
Our studies have identified a stress-activated mechanism (the JNK signalling pathway) as a therapeutic target in the treatment of kidney disease. The current project will define the role of JNK signaling in individual cell types in the development of different types of kidney disease. These studies will provide new insights into the pathogenesis of kidney disease, and will be highly relevant to other diseases, including atherosclerosis, lung fibrosis and arthritis.
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TGF-beta/Smad signalling in macrophage-mediated renal fibrosis.
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Mineralocortioid Receptor-Mediated Injury in Progressive Kidney Disease
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依托单位:
Mineralocortioid Receptor-Mediated Injury in Progressive Kidney Disease
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Modulating Inflammatory and Fibrogenic Pathways in Kidney Disease using a novel antagonist of Protease-Activated-Receptor-2
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依托单位:
Modulating Inflammatory and Fibrogenic Pathways in Kidney Disease using a novel antagonist of Protease-Activated-Receptor-2
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New strategies for the treatment of kidney disease.
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Smad3 acetylation modulates organ fibrosis
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Apoptosis signal-regulating kinase 1 (ASK1) is a major pathway of stress-induced renal injury in different types of progressive kidney disease.
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依托单位:
New roles for the spleen tyrosine kinase in antibody-independent renal injury.
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批准号:nhmrc : 606400
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Selective targeting of acute renal injury by inhibition of the receptor tyrosine kinase, c-fms.
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TAK1 - a novel regulator of renal inflammation and fibrosis.
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Therapeutic targetting of MIF in type 2 diabetes
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资助金额:$34.65万
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依托单位:
Lefty - a novel anti-fibrotic molecule for the treatment of kidney disease
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