Selective targeting of acute renal injury by inhibition of the receptor tyrosine kinase, c-fms.

通过抑制受体酪氨酸激酶 c-fms 选择性靶向急性肾损伤。

• 批准号: nhmrc : 606685
• 负责人: A/Pr David Nikolic-Paterson
• 金额: $ 29.54万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/selective-targeting-acute-c-fms/95910
• 关键词: Selective; targeting; acute; renal; injury

The progression of kidney disease to end-stage renal failure is a major health problem in our community. We have identified that macrophages, a type of white blood cell, plays an important role in causing inflammatory kidney injury. This project will use clinically relevant animal models to test the therapeutic potential of our new approach to selectively remove these cells from the inflamed kidney and thereby protect it from injury.

肾脏疾病的进展到终末期肾功能衰竭是我们社区的一个主要健康问题。我们已经确认巨噬细胞是白细胞的一种，在引起炎性肾损伤中起着重要作用。该项目将使用临床相关的动物模型来测试我们的新方法的治疗潜力，该方法选择性地从炎症的肾脏中移除这些细胞，从而保护它免受伤害。