Modulating Inflammatory and Fibrogenic Pathways in Kidney Disease using a novel antagonist of Protease-Activated-Receptor-2
Modulating Inflammatory and Fibrogenic Pathways in Kidney Disease using a novel antagonist of Protease-Activated-Receptor-2
批准号:
nhmrc : GNT1083131
负责人:
A/Pr David Nikolic-Paterson
金额:
$38.75万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2015
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2015-01-01 至 2017-12-31
中文摘要
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英文摘要
Chronic kidney disease (CKD) now affects 10% of adults in industrialised countries. Current treatments are largely ineffective. Thus developing better CKD treatments will have substantial public health benefit. Three well established and clinically relevant animal models of kidney disease will be used to test the ability of a new experimental anti-inflammatory drug, developed by members of this research team at The University of Queensland, to prevent or lessen the progression of CKD.
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会议论文
TGF-beta/Smad signalling in macrophage-mediated renal fibrosis.
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批准号:nhmrc : 1122073
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项目类别:Project Grants
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资助金额:$46.66万
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财政年份:2017
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负责人:A/Pr David Nikolic-Paterson
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依托单位:
Defining the central role of podocyte depletion in the development, progression and management of glomerular disease
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批准号:nhmrc : GNT1121793
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项目类别:Project Grants
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资助金额:$69.09万
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财政年份:2017
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负责人:A/Pr David Nikolic-Paterson
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依托单位:
Defining the central role of podocyte depletion in the development, progression and management of glomerular disease
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批准号:nhmrc : 1121793
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项目类别:Project Grants
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资助金额:$47.17万
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财政年份:2017
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负责人:A/Pr David Nikolic-Paterson
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依托单位:
TGF-beta/Smad signalling in macrophage-mediated renal fibrosis.
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批准号:nhmrc : GNT1122073
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项目类别:Project Grants
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资助金额:$68.37万
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财政年份:2017
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负责人:A/Pr David Nikolic-Paterson
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依托单位:
Mineralocortioid Receptor-Mediated Injury in Progressive Kidney Disease
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批准号:nhmrc : GNT1102882
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项目类别:Project Grants
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资助金额:$70.7万
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财政年份:2016
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负责人:A/Pr David Nikolic-Paterson
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依托单位:
Mineralocortioid Receptor-Mediated Injury in Progressive Kidney Disease
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批准号:nhmrc : 1102882
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项目类别:Project Grants
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资助金额:$48.47万
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财政年份:2016
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负责人:A/Pr David Nikolic-Paterson
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依托单位:
Modulating Inflammatory and Fibrogenic Pathways in Kidney Disease using a novel antagonist of Protease-Activated-Receptor-2
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批准号:nhmrc : 1083131
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项目类别:Project Grants
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资助金额:$39.89万
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财政年份:2015
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负责人:A/Pr David Nikolic-Paterson
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依托单位:
Spleen tyrosine kinase (Syk) as a therapeutic target in antibody-dependent transplant rejection.
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批准号:nhmrc : 1057565
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项目类别:Project Grants
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资助金额:$41.74万
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财政年份:2014
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负责人:A/Pr David Nikolic-Paterson
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依托单位:
New strategies for the treatment of kidney disease.
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批准号:nhmrc : GNT1058175
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项目类别:Research Fellowships
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资助金额:$66.45万
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财政年份:2014
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负责人:A/Pr David Nikolic-Paterson
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依托单位:
Mechanistic and translational studies targeting kidney inflammation and fibrosis.
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批准号:nhmrc : 1058175
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项目类别:Research Fellowships
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资助金额:$46.49万
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财政年份:2014
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负责人:A/Pr David Nikolic-Paterson
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依托单位:
Smad3 acetylation modulates organ fibrosis
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批准号:nhmrc : 1057581
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项目类别:Project Grants
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资助金额:$45.55万
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财政年份:2014
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负责人:A/Pr David Nikolic-Paterson
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依托单位:
Apoptosis signal-regulating kinase 1 (ASK1) is a major pathway of stress-induced renal injury in different types of progressive kidney disease.
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批准号:nhmrc : 1044289
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项目类别:Project Grants
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资助金额:$45.27万
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财政年份:2013
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负责人:A/Pr David Nikolic-Paterson
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依托单位:
New roles for the spleen tyrosine kinase in antibody-independent renal injury.
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批准号:nhmrc : 1002079
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项目类别:NHMRC Project Grants
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资助金额:$38.33万
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财政年份:2011
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负责人:A/Pr David Nikolic-Paterson
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依托单位:
Distinct pathogenic roles for JNK signalling in glomerular and interstitial injury in kidney disease.
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批准号:nhmrc : 1006348
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项目类别:NHMRC Project Grants
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资助金额:$37.07万
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财政年份:2011
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负责人:A/Pr David Nikolic-Paterson
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依托单位:
Resolvin E1 is a novel anti-inflammatory and anti-fibrotic lipid mediator for the treatment of chronic kidney disease.
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批准号:nhmrc : 606400
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项目类别:NHMRC Project Grants
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资助金额:$34.62万
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财政年份:2010
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负责人:A/Pr David Nikolic-Paterson
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依托单位:
Selective targeting of acute renal injury by inhibition of the receptor tyrosine kinase, c-fms.
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批准号:nhmrc : 606685
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项目类别:NHMRC Project Grants
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资助金额:$29.54万
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财政年份:2010
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负责人:A/Pr David Nikolic-Paterson
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依托单位:
TAK1 - a novel regulator of renal inflammation and fibrosis.
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批准号:nhmrc : 494822
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项目类别:NHMRC Project Grants
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资助金额:$35.85万
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财政年份:2008
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负责人:A/Pr David Nikolic-Paterson
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依托单位:
Therapeutic targetting of MIF in type 2 diabetes
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批准号:nhmrc : 494823
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项目类别:NHMRC Project Grants
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资助金额:$34.65万
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财政年份:2008
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负责人:A/Pr David Nikolic-Paterson
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依托单位:
Lefty - a novel anti-fibrotic molecule for the treatment of kidney disease
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批准号:nhmrc : 388902
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项目类别:NHMRC Project Grants
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资助金额:$28.4万
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财政年份:2007
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负责人:A/Pr David Nikolic-Paterson
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依托单位:
Role of JNK and p38 MAPK signalling in diabetic nephropathy
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批准号:nhmrc : 338517
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项目类别:NHMRC Project Grants
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资助金额:$30.31万
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财政年份:2005
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负责人:A/Pr David Nikolic-Paterson
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依托单位:
海外基金