Conformal laser thermal therapy for epithelial cancer
适形激光热疗治疗上皮癌
基本信息
- 批准号:7187128
- 负责人:
- 金额:$ 24.79万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2007
- 资助国家:美国
- 起止时间:2007-09-10 至 2008-08-31
- 项目状态:已结题
- 来源:
- 关键词:3-DimensionalAffectAreaBarrett EsophagusBirefringenceBlood flowClinicalDataDependenceDepthDiagnosisDiagnosticDiagnostic ImagingDimensionsDiseaseDysplasiaEarly treatmentEpithelialEpitheliumEsophageal AdenocarcinomaEsophagusEyeFacility Construction Funding CategoryFamily suidaeFeedbackGoalsHeatingHistologyImageImaging TechniquesImaging technologyIn SituIn VitroInjuryIntestinal MetaplasiaIntraepithelial NeoplasiaLasersLesionLifeLocalizedLow-Level Laser TherapyMalignant NeoplasmsMapsMeasurementMethodsMetricMicroscopicMonitorMotionMucous MembraneNeoplasm MetastasisNormal tissue morphologyOptical MethodsPatientsPhaseProceduresProtein DenaturationRangeResearchResearch PersonnelResolutionScanningScreening procedureSignal TransductionSpecimenSpottingsSurfaceSystemTechniquesTechnologyTemperatureTestingTherapeuticTimeTissuesWaterabsorptionbasebody systemcell killingfallsheat injuryimprovedin vivoinnovationinstrumentnovelprogramsresponsesize
项目摘要
DESCRIPTION (provided by applicant): Although the vast majority of cancers arise within readily accessible epithelial surfaces, therapy of epithelial cancers and their precursors remains woefully inadequate for many organ systems. The primary challenges for treating these lesions are 1) oftentimes they are not visible by eye, 2) they may be spatially heterogeneous and distributed over a large surface area, and 3) collateral damage to adjacent, non-involved tissues may cause significant complications. The overall objective of the proposed research is to develop a greatly improved therapeutic technique, 'conformal laser therapy,' for the treatment of epithelial cancers and their precursors. An important component of our approach is comprehensive diagnostic screening, which provides a detailed map of the disease distribution over large mucosal surface areas. Using this map, therapy can be directed to regions known to harbor disease. Unlike prior laser therapies, however, our method has the ability to conform the treatment region (in three-dimensions) to the diseased tissue volume, while minimizing collateral damage. This innovative approach integrates screening with real-time methods for controlling the laser treatment volume based on feedback signals obtained by monitoring local laser- tissue interactions. Conformal laser therapy will leverage 3-dimensional microstructural imaging technology and diagnostic criteria that we have established for comprehensive wide-field screening of epithelial disease. The objective of the R21 is to develop and test methods for monitoring and control. Novel high-resolution, cross-sectional imaging techniques will be investigated for dynamic monitoring of the microscopic consequences of thermal excitation and protein denaturation. In order to control treatment volume, we will exploit the wavelength- dependence of water absorption in the near-infrared (1350-1450 nm), using a tunable laser to vary the depth of thermal injury. Results from the R21 research will guide the construction of a clinically viable system and endoscopic probe for conformal laser therapy during the R33-phase. This instrument will be tested in living swine and the accuracy of this approach for selectively treating epithelial tissues will be determined. Although we focus our research on improving treatment of Barrett's esophagus, this technology will also serve as a platform for wide-field epithelial therapy in a variety of other organ systems where comprehensive treatment and minimal collateral damage are critical.
描述(由申请人提供):尽管绝大多数癌症发生在易于接近的上皮表面,但上皮癌及其前体的治疗对于许多器官系统来说仍然严重不足。治疗这些病变的主要挑战是 1) 通常肉眼看不到它们,2) 它们可能在空间上异质并分布在很大的表面积上,3) 对邻近非受累组织的附带损伤可能会导致严重的并发症。拟议研究的总体目标是开发一种大大改进的治疗技术,即“适形激光疗法”,用于治疗上皮癌及其癌前病变。我们方法的一个重要组成部分是全面的诊断筛查,它提供了大粘膜表面区域疾病分布的详细图谱。使用这张图,可以将治疗针对已知存在疾病的区域。然而,与之前的激光疗法不同,我们的方法能够使治疗区域(三维)符合患病组织体积,同时最大限度地减少附带损伤。这种创新方法将筛选与实时方法相结合,根据通过监测局部激光-组织相互作用获得的反馈信号来控制激光治疗量。适形激光治疗将利用我们为上皮疾病进行全面广域筛查而建立的 3 维微结构成像技术和诊断标准。 R21 的目标是开发和测试监测和控制方法。将研究新型高分辨率横截面成像技术,用于动态监测热激发和蛋白质变性的微观后果。为了控制治疗量,我们将利用近红外(1350-1450 nm)中水吸收的波长依赖性,使用可调谐激光来改变热损伤的深度。 R21 研究的结果将指导在 R33 阶段构建临床上可行的适形激光治疗系统和内窥镜探头。该仪器将在活体猪中进行测试,并将确定这种选择性治疗上皮组织方法的准确性。尽管我们的研究重点是改善巴雷特食管的治疗,但该技术也将作为各种其他器官系统的广域上皮治疗的平台,在这些器官系统中,综合治疗和最小的附带损害至关重要。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Brett E Bouma其他文献
Technology Insight: optical coherence tomography—current status and future development
技术洞察:光学相干断层扫描——现状与未来发展
- DOI:
10.1038/ncpcardio0482 - 发表时间:
2006-03-01 - 期刊:
- 影响因子:44.200
- 作者:
Adrian F Low;Guillermo J Tearney;Brett E Bouma;Ik-Kyung Jang - 通讯作者:
Ik-Kyung Jang
Brett E Bouma的其他文献
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{{ truncateString('Brett E Bouma', 18)}}的其他基金
Dual-modality FLIm and PSOCT for intravascular imaging of plaque in patients
双模态 FLIm 和 PSOCT 用于患者斑块血管内成像
- 批准号:
10677774 - 财政年份:2021
- 资助金额:
$ 24.79万 - 项目类别:
Dual-modality FLIm and PSOCT for intravascular imaging of plaque in patients
双模态 FLIm 和 PSOCT 用于患者斑块血管内成像
- 批准号:
10306091 - 财政年份:2021
- 资助金额:
$ 24.79万 - 项目类别:
Center for Biomedical OCT Research and Translation
生物医学OCT研究与转化中心
- 批准号:
9521706 - 财政年份:2017
- 资助金额:
$ 24.79万 - 项目类别:
Intracoronary imaging of plaque collagen in patients
患者斑块胶原的冠状动脉内成像
- 批准号:
8735353 - 财政年份:2014
- 资助金额:
$ 24.79万 - 项目类别:
Intracoronary imaging of plaque collagen in patients
患者斑块胶原的冠状动脉内成像
- 批准号:
9263997 - 财政年份:2014
- 资助金额:
$ 24.79万 - 项目类别:
Intracoronary imaging of plaque collagen in patients
患者斑块胶原的冠状动脉内成像
- 批准号:
8842192 - 财政年份:2014
- 资助金额:
$ 24.79万 - 项目类别:
Increasing the diagnostic yield of low-risk bronchial biopsy in the evaluation of
提高低风险支气管活检评估的诊断率
- 批准号:
8531402 - 财政年份:2013
- 资助金额:
$ 24.79万 - 项目类别:
Increasing the diagnostic yield of low-risk bronchial biopsy in the evaluation of
提高低风险支气管活检评估的诊断率
- 批准号:
8654306 - 财政年份:2013
- 资助金额:
$ 24.79万 - 项目类别:
Center for Biomedical OCT Research and Translation
生物医学OCT研究与转化中心
- 批准号:
10494619 - 财政年份:2011
- 资助金额:
$ 24.79万 - 项目类别:
Center for Biomedical OCT Research and Translation
生物医学OCT研究与转化中心
- 批准号:
8078519 - 财政年份:2011
- 资助金额:
$ 24.79万 - 项目类别:
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