Advance Clinical and Translational Research (Advance-CTR)

高级临床和转化研究（Advance-CTR）

• 批准号: 10726129
• 负责人: Sharon Irene Smith Rounds
• 金额: $ 30.79万
• 依托单位: BROWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-01 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10726129
• 关键词: Acceleration; Address; Area; Award; Basic Science; Big Data; Biological; Biometry; Caring; Clinical; Clinical Research; Clinical Sciences; Clinical effectiveness; Collaborations; Communities; Community Mental Health Services; Community Outreach; Core Facility; Data; Development; Discipline of Nursing; Education; Environment; Epidemiology; Evolution; Extramural Activities; Fostering; Funding; Funding Opportunities; Future; Goals; Government Agencies; Grant; Health; Health Policy; Health Priorities; Health Services; Health system; Healthcare Systems; Home; Hospitals; Human Resources; Infrastructure; Institution; Learning; Longevity; Mentors; Modeling; National Institute of General Medical Sciences; New England; Nonprofit Organizations; Outcome; Pharmacy facility; Pilot Projects; Population; Positioning Attribute; Productivity; Program Development; Program Evaluation; Protocols documentation; Public Health; Publications; Research; Research Design; Research Infrastructure; Research Personnel; Research Proposals; Research Support; Resources; Rhode Island; Services; Teacher Professional Development; Testing; Training; Translating; Translational Research; United States National Institutes of Health; Universities; Vulnerable Populations; bench to bedside; biomedical informatics; career; career development; clinical application; clinical infrastructure; clinical practice; clinical translation; community engaged research; community engagement; community organizations; coronavirus disease; cost; demographics; health care delivery; health disparity; health equity; hospital organization; improved; innovation; laboratory development; multidisciplinary; organizational structure; patient oriented; prevent; programs; success; synergism; translational research program; translational scientist; virtual

ABSTRACT – OVERALL The universities, hospitals, government agencies and community organizations in Rhode Island are well positioned to bridge the gaps between the worlds of clinical and basic science. Rhode Island’s small size, population demographics, and organizational structure are assets and present opportunities to implement and test transformative clinical and translational research. The health care delivery environment within the state is highly conducive to clinical research due to the relatively limited number of health care systems. Further contributing to Rhode Island’s translational research infrastructure are a number of well-organized Institutional Developmental Award (IDeA) Programs, each with core facility, faculty development and collaborative research resources. But despite Rhode Island’s impressive educational institutions, streamlined clinical environment, and successful IDeA sponsored research and mentoring programs, the majority of these resources have not been coordinately focused towards developing a multi-institutional, clinical and translational research infrastructure that would serve to improve the effectiveness of clinical practice and health care policy in Rhode Island. The objective of the Advance Clinical and Translation Research Award (Advance-CTR) is to bridge these infrastructure gaps by creating an overarching, multidisciplinary, central organization to better coordinate and leverage existing resources for program management and thereby provide the infrastructure necessary to address current and future health concerns in Rhode Island. The goals of the Advance-CTR are to: 1. Educate, mentor and encourage young investigators in clinical research professional development. 2. Eliminate the obstacles that may prevent researchers from pursuing clinical research initiatives that can lead to funded research programs. 3. Bring together the diverse clinical research resources to provide a virtual home that facilitates new collaborations and enhanced efficiencies. 4. Facilitate research to gather preliminary data necessary for developing competitive research proposals. 5. Provide contemporary infrastructure for clinical and translational research including research planning and implementation, advanced biostatistics and epidemiology support and biomedical informatics. 6. Foster coordination between translational researchers at our participating entities so as to create new productive collaborations with translational outcomes. 7. Sustain a clinical translational research environment by providing the necessary management and coordination of resources. 8. Create an innovative Tracking and Evaluation program that will combine support requests with use and cost data and apply lessons learned in the CTSA program to the CTR environment.

摘要-总体 罗得岛的大学、医院、政府机构和社区组织都很好 定位于弥合临床和基础科学世界之间的差距。罗得岛面积小， 人口统计数据和组织结构是资产，并提供实施的机会， 测试变革性临床和转化研究。国家的卫生保健提供环境是 由于卫生保健系统的数量相对有限，因此非常有利于临床研究。进一步 为罗得岛的转化研究基础设施做出贡献的是一些组织良好的机构 发展奖（IDEA）计划，每个核心设施，教师发展和协作 研究资源。但是，尽管罗得岛有令人印象深刻的教育机构， 环境，以及成功的IDEA赞助的研究和指导计划，其中大多数 资源没有协调地集中在发展一个多机构，临床和 转化研究基础设施，有助于提高临床实践的有效性， 罗得岛的医疗保健政策。高级临床和翻译研究奖的目的 （Advance-CTR）旨在通过创建一个全面的、多学科的、中心的 组织更好地协调和利用现有资源进行项目管理， 提供必要的基础设施，以解决罗得岛当前和未来的健康问题。的目标 Advance-CTR的目标是： 1.教育，指导和鼓励年轻的研究人员在临床研究专业发展。 2.消除可能阻碍研究人员开展临床研究的障碍， 导致资助的研究项目。 3.汇集各种临床研究资源，提供一个虚拟的家， 合作和提高效率。 4.促进研究，收集必要的初步数据，以制定有竞争力的研究建议。 5.为临床和转化研究提供现代基础设施，包括研究规划 高级生物统计和流行病学支助以及生物医学信息学。 6.促进我们参与实体的翻译研究人员之间的协调，以创造新的 富有成效的合作与翻译成果。 7.通过提供必要的管理来维持临床转化研究环境， 协调资源。 8.创建一个创新的跟踪和评估计划，将联合收割机支持请求与使用和 成本数据，并将CTSA计划中的经验教训应用于CTR环境。

项目成果

Detection of clonotypic DNA in the cerebrospinal fluid as a marker of central nervous system invasion in lymphoma.

• DOI: 10.1182/bloodadvances.2021004512
• 发表时间: 2021-12-28
• 期刊: Blood advances
• 影响因子: 7.5
• 作者: Olszewski AJ;Chorzalska AD;Petersen M;Ollila TA;Zayac A;Kurt H;Treaba DO;Reagan JL;Hsu A;Egan PC;Butera J;Niroula R;Vatkevich J;Robison J;Sahin I;Jacob AP;Mullins CD;Dubielecka PM
• 通讯作者: Dubielecka PM

Wealth and depression: A scoping review.

• DOI: 10.1002/brb3.2486
• 发表时间: 2022-03
• 期刊: Brain and behavior
• 影响因子: 3.1
• 作者: Ettman CK;Adam GP;Clark MA;Wilson IB;Vivier PM;Galea S
• 通讯作者: Galea S

Association of Emergency Department Evaluation With Public Insurance Use and Treatment Delays for ACL Injury.

• DOI: 10.1177/23259671231212241
• 发表时间: 2023-11
• 期刊: ORTHOPAEDIC JOURNAL OF SPORTS MEDICINE
• 影响因子: 2.6
• 作者: Zhu, Angela S.;Morrissey, Patrick;Byrne, Rory A.;Albright, J. Alex;Lemme, Nicholas J.;Cruz, Aristides I.;Owens, Brett D.
• 通讯作者: Owens, Brett D.

Implementing an Open Source Electronic Health Record System in Kenyan Health Care Facilities: Case Study.

• DOI: 10.2196/medinform.8403
• 发表时间: 2018-04-18
• 期刊: JMIR medical informatics
• 影响因子: 3.2
• 作者: Muinga N;Magare S;Monda J;Kamau O;Houston S;Fraser H;Powell J;English M;Paton C
• 通讯作者: Paton C

Current Concepts in Meniscus Tissue Engineering and Repair.

• DOI: 10.1002/adhm.201701407
• 发表时间: 2018-06
• 期刊: Advanced healthcare materials
• 影响因子: 10
• 作者: Bilgen B;Jayasuriya CT;Owens BD
• 通讯作者: Owens BD