Renovation of Building 4 to Provide BSL-2 Housing for Infectious Disease Research

描述（由申请人提供）：传染病研究已经并将继续是西南国家灵长类动物研究中心（SNPRC） phs支持的研究项目的重要组成部分。NPRC计划为核心教师和需要非人类灵长类动物模型的更广泛的研究社区成员提供资源和专业知识。传染病研究的最新趋势，包括需要恒河猴模型的艾滋病相关研究和生物防御/新发感染研究，导致越来越需要为需要严格控制的项目提供服务。在SNPRC，缺乏可用于研究方案的非人类灵长类动物的BSL-2空间导致延误，阻碍了我们开展传染病（包括艾滋病相关）研究的能力。

DESCRIPTION (provided by applicant): Research on infectious diseases has been and will continue to be an important component of the PHS-supported research program at the Southwest National Primate Research Center (SNPRC). The NPRC program makes available resources and expertise to core faculty and to members of the broader research community who require nonhuman primate models. Recent trends in infectious disease research, including AIDS-related research requiring rhesus macaque models and biodefense/emerging infections research, have resulted in an increased need to service projects requiring stringent containment. At the SNPRC, the lack of BSL-2 space available for housing nonhuman primates on research protocols has resulted in delays that impede our ability to conduct infectious disease, including AIDS-related, research. This application seeks funds to improve the infrastructure at SNPRC by renovation of an existing 3,280 gross square foot building to provide new BSL-2 containment for nonhuman primates. The renovated building will contain three animal housing rooms providing a total of 1,593 square feet of housing space, a 185 square foot procedure room, and associated support spaces, and will remediate current deficiencies of space utilization and traffic movement. The existing heating, ventilation and air conditioning system, which provides recirculated air, will be replaced with a new system providing 100% fresh air. Other building systems, including electrical distribution equipment and wiring and plumbing, both of which date from original construction in 1966, will be replaced and upgraded during the renovation to provide reliable service and adequate capacity.