Center for Immunology of Emerging Infectious Diseases

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Dengue virus (DENV) infection of humans has steadily increased in importance as an emerging infectious disease, and the development of protective vaccines to DENV disease has been impeded by a lack of understanding of virus-specific immune responses and their role in OT. 7"o protection and disease. To address these critical issues related to DENV infection and disease, we have established a unique collaborative consortium, the Center for Immunology of Emerging Infectious Diseases (CIEID) located at the University of Pittsburgh. The focus of the CIEID is to conduct comprehensive analysis of immune responses to DENV virus infection of humans using the unique clinical samples previously obtained from patients in Recife, Brazil, and now archived at the Center for Vaccine Research at the University of Pittsburgh. We will use these samples to characterize the initial role of antigen-presenting cells in DENV immunopathogenesis (Project 1), to define the interaction of T-Iymphocytes with dendritic cells in the progression of immunity --. `". man <C) 0007 .O- (3p =!! and disease (Project 2), and to define how DENV suppresses innate immune responses to DENV infection (Project 3). These translational immunology studies will be supported by a combined administrative and clinical core. It is anticipated that the results of the proposed studies will produce important new insights into the role of DENy-specific immunity in infection and disease that can then inform strategies for treatment and vaccine development. It is also expected that the CIEID will provide platform technologies and comprehensive expertise in translational immunology that can readily be applied to other emerging infectious diseases or 3-6 m_3 0-3 ti. (OD biodefense pathogens.