Bacterial Essential and Virulence Gene

细菌必需基因和毒力基因

• 批准号: 7617435
• 负责人: Colin Manoil
• 金额: $ 34.97万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-03-01 至 2009-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7617435
• 关键词: Affect; Affinity Chromatography; Alleles; Antibiotic Resistance; Antibiotics; Attenuated Live Virus Vaccine; Bacteriophage lambda; Biological Testing; Burkholderia pseudomallei; Chromosomes; Collection; Epitopes; Escherichia coli; Essential Genes; Francisella tularensis; Gene Fusion; Generations; Genes; Genetic; Genetic Recombination; In Vitro; Individual; Infection; Libraries; Methods; Molecular Profiling; Mus; Mutation; Polymerase Chain Reaction; Production; Proteomics; Reporter; Rodent Model; Screening procedure; Virulence; Virulence Factors; Yersinia pestis; base; drug development; high throughput screening; in vivo; loss of function; macrophage; mutant

WWAMI RCE Project 2: Bacterial Essential & Virulence Genes The project proposes to generate saturating libraries of sequence-defined transposon insertion mutants in B. pseudornallei, F. tularensis and Y. pestis. The libraries should facilitate comprehensive identification of essential genes, virulence determinants and antibiotic resistance determinants for the three species.

WWAMIRCE项目2：细菌必需基因和毒力基因 该项目建议在B.中生成序列定义的转座子插入突变体的饱和文库。 Passornallei、F.tularensis和鼠疫耶尔森菌。图书馆应促进全面识别 这三个物种的基本基因、毒力决定因素和抗生素抗性决定因素。