Bacterial Phenotypic Diversity
Bacterial Phenotypic Diversity
批准号:
8236984
负责人:
Colin Manoil
金额:
$29.29万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2011
资助国家:
美国
项目状态:
已结题
起止时间:
2011-03-01 至 2014-02-28
关键词:
AchievementAnti-Bacterial AgentsAntibiotic ResistanceBase SequenceBurkholderia pseudomalleiCenters of Research ExcellenceDatabasesDiagnosticDiagnostic testsDrug Delivery SystemsEmerging Communicable DiseasesGenerationsGenesGoalsGrowthLibrariesPhenotypePhysiologicalResearchResistanceStressTechnologyTestingVariantVirulencebasebiodefenseinsightmutantresearch studystress tolerancetrait
中文摘要
该研究的主要目标是确定负责几种内在抗生素的FT和BP基因
抗性、毒力和耐逆性状。这些结果应该提供机械的见解,
生理基础,并可能确定潜在的抗菌药物的目标。附加的一组
实验将有助于确定BP物种多样性在这些和其他表型,并可能确定诊断
测试以区分自然分离物。作为该项目的一部分,新一代测序技术
用于评估转座子突变库的组成。
英文摘要
The primary goal of the research is to identify the FT and BP genes responsible for several intrinsic antibiotic
resistance, virulence and stress tolerance traits. The results should provide mechanistic insights into the
physiological basis of each and may identify potential antibacterial drug targets. An additional set of
experiments will help define BP species diversity in these and other phenotypes, and may identify diagnostic
tests to differentiate natural isolates. As part of the project, a new-generation sequencing-based technology
for assessing the makeup of transposon mutant pools of will be developed.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Defining the antibiotic intrinsic resistome of Acinetobacter baumannii
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批准号:10220708
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项目类别:
-
资助金额:$27.21万
-
财政年份:2019
-
负责人:Colin Manoil
-
依托单位:
Defining the antibiotic intrinsic resistome of Acinetobacter baumannii
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批准号:10064113
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项目类别:
-
资助金额:$27.21万
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财政年份:2019
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负责人:Colin Manoil
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依托单位:
Targeting chronic Pseudomonas aeruginosa wound infections
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批准号:8509966
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项目类别:
-
资助金额:$23.01万
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财政年份:2013
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负责人:Colin Manoil
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依托单位:
Targeting chronic Pseudomonas aeruginosa wound infections
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批准号:8626358
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项目类别:
-
资助金额:$19.02万
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财政年份:2013
-
负责人:Colin Manoil
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依托单位:
Assigning function of unknown genes of Acinetobacter baumanii by use of genetic
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批准号:8597717
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项目类别:
-
资助金额:$35.88万
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财政年份:2013
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负责人:Colin Manoil
-
依托单位:
Bacterial Mutant Library Core
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批准号:8236990
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项目类别:
-
资助金额:$21.86万
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财政年份:2011
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负责人:Colin Manoil
-
依托单位:
Bacterial Mutant Library Core
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批准号:7675902
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项目类别:
-
资助金额:$21.14万
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财政年份:2009
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负责人:Colin Manoil
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依托单位:
Bacterial Phenotypic Diversity
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批准号:7675874
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项目类别:
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资助金额:$28.58万
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财政年份:2009
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负责人:Colin Manoil
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依托单位:
Undermining aminoglycoside resistance in Pseudomonas aeruginosa
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批准号:7460318
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项目类别:
-
资助金额:$22.7万
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财政年份:2008
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负责人:Colin Manoil
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依托单位:
Bacterial Essential and Virulence Gene
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批准号:7617435
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项目类别:
-
资助金额:$34.97万
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财政年份:2008
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负责人:Colin Manoil
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依托单位:
Undermining aminoglycoside resistance in Pseudomonas aeruginosa
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批准号:7642380
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项目类别:
-
资助金额:$18.98万
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财政年份:2008
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负责人:Colin Manoil
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依托单位:
Bacterial Strain
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批准号:7640331
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项目类别:
-
资助金额:$22.44万
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财政年份:2008
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负责人:Colin Manoil
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依托单位:
Alternatives to antibiotic resistance selective markers for Francisella
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批准号:7287111
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项目类别:
-
资助金额:$23.13万
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财政年份:2007
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负责人:Colin Manoil
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依托单位:
Alternatives to antibiotic resistance selective markers for Francisella
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批准号:7415216
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项目类别:
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资助金额:$18.86万
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财政年份:2007
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负责人:Colin Manoil
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依托单位:
Genetic tools for analyzing B. pseudomallei virulence
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批准号:7084476
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项目类别:
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资助金额:$18.5万
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财政年份:2005
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负责人:Colin Manoil
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依托单位:
Genetic tools for analyzing B. pseudomallei virulence
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批准号:6905789
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项目类别:
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资助金额:$22.61万
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财政年份:2005
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负责人:Colin Manoil
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依托单位:
C. elegans models for human transport disorders
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批准号:6440275
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项目类别:
-
资助金额:$14.94万
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财政年份:2001
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负责人:Colin Manoil
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依托单位:
C. elegans models for human transport disorders
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批准号:6526907
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项目类别:
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资助金额:$15.2万
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财政年份:2001
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负责人:Colin Manoil
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依托单位:
DETERMINANTS OF A SIMPLE MEMBRANE PROTEIN TOPOLOGY
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批准号:2183982
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项目类别:
-
资助金额:$8.52万
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财政年份:1991
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负责人:Colin Manoil
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依托单位:
DETERMINANTS OF A SIMPLE MEMBRANE PROTIN TOPOLOGY
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批准号:2183979
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项目类别:
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资助金额:$6.33万
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财政年份:1991
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负责人:Colin Manoil
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依托单位:
海外基金