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Defining the antibiotic intrinsic resistome of Acinetobacter baumannii

Defining the antibiotic intrinsic resistome of Acinetobacter baumannii
鲍曼不动杆菌抗生素固有耐药组的定义
批准号：
10220708
负责人：
Colin Manoil
金额：
$27.21万
依托单位：
UNIVERSITY OF WASHINGTON
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
项目状态：
已结题
起止时间：
2019-12-01 至 2023-08-31
来源：
https://reporter.nih.gov/project-details/10220708
关键词：
Acinetobacter baumanniiAllelesAntibiotic ResistanceAntibioticsBacteriaBiochemicalBiological AssayCell Membrane PermeabilityCell physiologyClinicalColistinDNADNA-Directed RNA PolymeraseEnzymesEssential GenesExhibitsFoundationsGene MutationGene OrderGoalsGrowthIn VitroInfectionMembraneMeropenemMethodsMutationPhenotypeProceduresResidual stateResistanceTestingTobramycinWorkbiological adaptation to stresscapsulecarbapenemaseclinically relevantcolistin resistanceefflux pumpexperimental studygenome-wideloss of functionmutantnew technologynovelnull mutationpathogenresistance generesistance mechanismtrait

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中文摘要
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英文摘要
The project aims to define the functional basis of Acinetobacter baumannii intrinsic resistance to three clinically-relevant antibiotics (meropenem, colistin, and tobramycin) at a comprehensive scale. The work will identify resistance functions at genome-scale using transposon mutant sequencing, and will validate results through single mutant testing. The study will employ new technology that makes it possible to include mutants inactivating essential genes, which is usually missing from such studies. Top, validated mutants exhibiting increased sensitivity to one or more of the antibiotics will be further evaluated for whether they act through established or novel resistance mechanisms.
期刊论文(2)
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科研奖励(0)
会议论文
Genetic Dissection of Antibiotic Adjuvant Activity.
DOI： 10.1128/mbio.03084-21
发表时间： 2022-02-22
期刊： mBio
影响因子： 6.4
作者： [Bailey J, Gallagher L, Barker WT, Hubble VB, Gasper J, Melander C, Manoil C]
通讯作者： Manoil C
Defining the antibiotic intrinsic resistome of Acinetobacter baumannii
  • 批准号：
    10064113
  • 项目类别：
  • 资助金额：
    $27.21万
  • 财政年份：
    2019
  • 负责人：
    Colin Manoil
  • 依托单位：
    UNIVERSITY OF WASHINGTON
Targeting chronic Pseudomonas aeruginosa wound infections
  • 批准号：
    8509966
  • 项目类别：
  • 资助金额：
    $23.01万
  • 财政年份：
    2013
  • 负责人：
    Colin Manoil
  • 依托单位：
    UNIVERSITY OF WASHINGTON
Targeting chronic Pseudomonas aeruginosa wound infections
  • 批准号：
    8626358
  • 项目类别：
  • 资助金额：
    $19.02万
  • 财政年份：
    2013
  • 负责人：
    Colin Manoil
  • 依托单位：
    UNIVERSITY OF WASHINGTON
Assigning function of unknown genes of Acinetobacter baumanii by use of genetic
  • 批准号：
    8597717
  • 项目类别：
  • 资助金额：
    $35.88万
  • 财政年份：
    2013
  • 负责人：
    Colin Manoil
  • 依托单位：
    UNIVERSITY OF WASHINGTON
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