NEIBank: Est Analysis And Bioinformatics For Ocular Genomics

许多人的眼睛（和耳朵）组织和重要的动物模型的组织现在已经被分析。此外，NEIBank的合作项目还增加了其他感觉组织、耳朵和味蕾的数据。最近增加的眼睛包括人类视神经，人类翼状胬肉，恒河猴和牛的晶状体和斑马鱼的角膜。该DNA资源已被用于创建含有13,000个非冗余人眼表达序列和6500个小鼠眼睛序列的cDNA微阵列。这些被用于分析人类细胞反应和转基因小鼠模型。来自NEIBank兔眼库的数据已被用于与佛罗里达大学的研究小组合作创建兔眼研究的第一个DNA微阵列。

Many human eye (and also ear) tissues and those of important animal models have now been analyzed. In addition NEIBank collaborations have added data on other sensory tissues, ear and taste bud. Recent eye additions include human optic nerve, human pterygium, rhesus monkey and cow lens and zebrafish cornea,. This DNA resource has been used to create cDNA microarrays with 13,000 non-redundant human eye expressed sequences and 6500 sequences from mouse eye. These are being used in analysis of human cellular responses and genetically modified mouse models. Data from NEIBank rabbit eye libraries have been used to create the first DNA microarray for rabbit eye research in collaboration with groups from the University of Florida. A powerful addition to the informatics tools for eye research is EyeBrowse, a dedicated genome browser for eye-expressed genes, produced in collaboration with CIT. http://eyebrowse.cit.nih.gov/genome/; a database for known human eye disease genes and a new tool to compare expression patterns of different tissues and species. In addition, NEIBank now incorporates data from the EyeSAGE project (Duke U) with a custom genome browser track for human eye-derived SAGE data. Another addition is a database of human eye disease genes which is currently undergoing update and annotation.