NEIBank: Est Analysis And Bioinformatics For Ocular Genomics

NEIBank：眼部基因组学的 Est 分析和生物信息学

• 批准号: 7734608
• 负责人: Graeme J Wistow
• 金额: $ 100.25万
• 依托单位: NATIONAL EYE INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7734608
• 关键词: Animal Model; Bioinformatics; Collaborations; Complex; Conjunctival Pterygium; DNA; DNA Microarray Chip; DNA Microarray format; Data; Databases; Development; Ear; Essential Genes; Expressed Sequence Tags; Eye; Eye diseases; Genes; Genetic; Genome; Genomics; Human; Hybrids; Informatics; Libraries; Modeling; Molecular; Molecular Profiling; Mus; Optic Nerve; Oryctolagus cuniculus; Protein Analysis; Range; Research; Resources; Sensory; System; Taste Buds; Tissues; Yeasts; cDNA Arrays; improved; mouse model; response; tool

Many human eye (and also ear) tissues and those of important animal models have now been analyzed. In addition NEIBank collaborations have added data on other sensory tissues, ear and taste bud. Recent eye additions include human optic nerve and human pterygium. This DNA resource has been used to create cDNA microarrays with 13,000 non-redundant human eye expressed sequences and 6500 sequences from mouse eye. These are being used in analysis of human cellular responses and genetically modified mouse models. A powerful addition to the informatics tools for eye research is EyeBrowse, a dedicated genome browser for eye-expressed genes, produced in collaboration with CIT. http://eyebrowse.cit.nih.gov/genome/. Major additions are an annotated database of human eye disease genes and databases of candidate eye disease regions of the genome which are displayed in EyeBrowse with all known human eye-derived cDNAs and SAGE data, indicating expression profiles specific to eye.

许多人类的眼睛(以及耳朵)组织和重要的动物模型的组织现在已经被分析。此外，NEIBank的合作还增加了其他感官组织、耳朵和味蕾的数据。最近增加的眼睛包括人类视神经和人类翼状胬肉。该DNA资源已被用来创建包含13,000个非冗余人眼表达序列和6500个来自小鼠眼睛的序列的基因芯片。这些正被用于分析人类细胞反应和转基因小鼠模型。 眼睛研究信息学工具的一个强大补充是EyeBrowse，这是与CIT合作开发的专门用于眼睛表达基因的基因组浏览器。Http://eyebrowse.cit.nih.gov/genome/.主要增加的是一个带注释的人类眼病基因数据库和基因组候选眼病区域的数据库，这些数据库与所有已知的人类眼睛衍生的cDNA和SAGE数据一起显示在EyeBrowse中，表明眼睛特有的表达谱。

项目成果

A project for ocular bioinformatics: NEIBank.

眼部生物信息学项目：NEIBank。

• 发表时间: 2002
• 期刊: Molecular vision
• 影响因子: 2.2
• 作者: Wistow,Graeme

Development of a microarray chip for gene expression in rabbit ocular research

• 发表时间: 2007-02
• 期刊: Molecular Vision
• 影响因子: 2.2
• 作者: M. Popp;Li Liu;A. Timmers;D. Esson;L. Shiroma;C. Meyers;S. Berceli;M. Tao;G. Wistow;G. Schultz;M. Sherwood

Grouping and identification of sequence tags (GRIST): bioinformatics tools for the NEIBank database.

序列标签的分组和识别 (GRIST)：NEIBank 数据库的生物信息学工具。

• 发表时间: 2002
• 期刊: Molecular vision
• 影响因子: 2.2
• 作者: Wistow,Graeme;Bernstein,StevenL;Touchman,JeffreyW;Bouffard,Gerald;Wyatt,MKeith;Peterson,Katherine;Behal,Amita;Gao,James;Buchoff,Patee;Smith,Don
• 通讯作者: Smith,Don

Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants.

NEIBank 项目的人类 RPE/脉络膜表达序列标签分析：超过 6000 个非冗余转录本、新基因和剪接变体。

• 发表时间: 2002
• 期刊: Molecular vision
• 影响因子: 2.2
• 作者: Wistow,Graeme;Bernstein,StevenL;Wyatt,MKeith;Fariss,RobertN;Behal,Amita;Touchman,JeffreyW;Bouffard,Gerald;Smith,Don;Peterson,Katherine
• 通讯作者: Peterson,Katherine

Expressed sequence tag analysis of adult human iris for the NEIBank Project: steroid-response factors and similarities with retinal pigment epithelium.

为 NEIBank 项目进行成人虹膜的表达序列标签分析：类固醇反应因子以及与视网膜色素上皮的相似性。

• 发表时间: 2002
• 期刊: Molecular vision
• 影响因子: 2.2
• 作者: Wistow,Graeme;Bernstein,StevenL;Ray,Sugata;Wyatt,MKeith;Behal,Amita;Touchman,JeffreyW;Bouffard,Gerald;Smith,Don;Peterson,Katherine
• 通讯作者: Peterson,Katherine