NEIBank：眼部基因组学的 Est 分析和生物信息学-猫眼课题宝

NEIBank：眼部基因组学的 Est 分析和生物信息学

批准号：

7734608

负责人：

Graeme J Wistow

金额：

$100.25万

依托单位：

NATIONAL EYE INSTITUTE

依托单位国家：

美国

项目类别：

财政年份：

资助国家：

美国

项目状态：

未结题

起止时间：

至

来源：

https://reporter.nih.gov/project-details/7734608

项目摘要

项目成果

Graeme J Wistow的其他基金

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中文摘要

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英文摘要

Many human eye (and also ear) tissues and those of important animal models have now been analyzed. In addition NEIBank collaborations have added data on other sensory tissues, ear and taste bud. Recent eye additions include human optic nerve and human pterygium. This DNA resource has been used to create cDNA microarrays with 13,000 non-redundant human eye expressed sequences and 6500 sequences from mouse eye. These are being used in analysis of human cellular responses and genetically modified mouse models. A powerful addition to the informatics tools for eye research is EyeBrowse, a dedicated genome browser for eye-expressed genes, produced in collaboration with CIT. http://eyebrowse.cit.nih.gov/genome/. Major additions are an annotated database of human eye disease genes and databases of candidate eye disease regions of the genome which are displayed in EyeBrowse with all known human eye-derived cDNAs and SAGE data, indicating expression profiles specific to eye.

期刊论文(10)

专著(0)

科研奖励(0)

会议论文

A project for ocular bioinformatics: NEIBank.

眼部生物信息学项目：NEIBank。

DOI： --

发表时间： 2002

期刊：

Molecular vision

影响因子： 2.2

作者：

[Wistow,Graeme]

通讯作者： Wistow,Graeme

Development of a microarray chip for gene expression in rabbit ocular research

DOI： --

发表时间： 2007-02

期刊：

Molecular Vision

影响因子： 2.2

作者：

[M. Popp;Li Liu;A. Timmers;D. Esson;L. Shiroma;C. Meyers;S. Berceli;M. Tao;G. Wistow;G. Schultz;M. Sherwood]

通讯作者： M. Popp;Li Liu;A. Timmers;D. Esson;L. Shiroma;C. Meyers;S. Berceli;M. Tao;G. Wistow;G. Schultz;M. Sherwood

Grouping and identification of sequence tags (GRIST): bioinformatics tools for the NEIBank database.

序列标签的分组和识别 (GRIST)：NEIBank 数据库的生物信息学工具。

DOI： --

发表时间： 2002

期刊：

Molecular vision

影响因子： 2.2

作者：

[Wistow,Graeme, Bernstein,StevenL, Touchman,JeffreyW, Bouffard,Gerald, Wyatt,MKeith, Peterson,Katherine, Behal,Amita, Gao,James, Buchoff,Patee, Smith,Don]

通讯作者： Smith,Don

Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants.

NEIBank 项目的人类 RPE/脉络膜表达序列标签分析：超过 6000 个非冗余转录本、新基因和剪接变体。

DOI： --

发表时间： 2002

期刊：

Molecular vision

影响因子： 2.2

作者：

[Wistow,Graeme, Bernstein,StevenL, Wyatt,MKeith, Fariss,RobertN, Behal,Amita, Touchman,JeffreyW, Bouffard,Gerald, Smith,Don, Peterson,Katherine]

通讯作者： Peterson,Katherine

Expressed sequence tag analysis of adult human iris for the NEIBank Project: steroid-response factors and similarities with retinal pigment epithelium.