Contingency Management for Alcohol Abuse Using Transdermal Alcohol Detection

使用透皮酒精检测进行酒精滥用应急管理

• 批准号: 7688126
• 负责人: NANCY P BARNETT
• 金额: $ 19.19万
• 依托单位: BROWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-15 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7688126
• 关键词: Abstinence; Adult; Alcohol abuse; Alcohol consumption; Alcohol or Other Drugs use; Alcoholic beverage heavy drinker; Alcohols; Biochemical; Clinical; Clinical Trials; Code; Data; Data Collection; Dependence; Detection; Devices; Drug usage; Elements; Ethanol Metabolism; Feedback; Goals; Heavy Drinking; Indium; Intervention; Interview; Liver; Measures; Monitor; Outcome; Participant; Patient Self-Report; Pharmaceutical Preparations; Phase; Population; Prevention; Procedures; Psychological reinforcement; Randomized Controlled Clinical Trials; Randomized Controlled Trials; Reading; Records; Reinforcement Schedule; Reporting; Research; Secure; Series; Skin; Sweat; System; Testing; Text; Time; Tobacco; Training; alcohol abstinence; alcohol abuse therapy; alcohol and other drug; alcohol measurement; alcohol misuse; alcohol monitoring; base; comparison group; computer network; contingency management; drinking; efficacy trial; follow up assessment; follow-up; high risk drinking; post intervention; programs; public health priorities; reinforcer; sensor; voucher; web site

DESCRIPTION (provided by applicant): Prevention and treatment of alcohol abuse is a significant research and public health priority. To date one of the most promising approaches for substance use reduction, contingency management (CM), has not been well studied with alcohol abusers. Contingency management interventions provide substance users with cash, vouchers, or some other reinforcer that is contingent upon a desired treatment goal. A primary reason that CM has not been widely studied as an alcohol treatment is that due the rapid metabolism of alcohol by the liver there has not been a reliable and feasible way to verify abstinence or drinking reductions. However, devices are now available that provide an indication of alcohol use based on the concentration of alcohol in perspiration. A transdermal sensor is worn close to the skin and can be monitored remotely, which makes it possible to immediately reinforce abstinence or reduction. The objective of this proposal is to study the initial efficacy of CM for reducing drinking among heavy drinkers who are willing to reduce or stop drinking. Following necessary adaptations to established procedural, data collection, and intervention components with group of 15 (Aim 1), we will conduct a small (N = 30) clinical trial in which we will compare a 3-week CM condition to yoked noncontingent reinforcement (NR) (Aim 2). Participants in CM will receive reinforcement that is contingent upon maintaining abstinence as measured by a transdermal alcohol monitor; participants in NR will receive yoked reinforcement that is not contingent on their transdermal alcohol levels. A project website will be used to collect daily records of drinking, provide feedback about detection of alcohol to participants, and provide reinforcers. Transdermal alcohol concentrations and self-report data will provide information about changes in drinking during the active phase of treatment, and a 1-month follow-up assessment will measure short-term post-intervention outcomes. Establishing these components and an initial effect size for CM are essential first steps in a program of research with CM and alcohol monitoring to treat alcohol misuse and dependence. Our eventual goal is to conduct larger clinical trials to more rigorously evaluate the short and long-term outcomes of CM with this and other high-risk drinking populations.

描述（由申请人提供）：预防和治疗酒精滥用是一项重要的研究和公共卫生优先事项。迄今为止最有希望的药物使用方法之一

项目成果

Characterising patterns of alcohol use among heavy drinkers: A cluster analysis utilising alcohol biosensor data.

• DOI: 10.1111/dar.13306
• 发表时间: 2021-11
• 期刊: DRUG AND ALCOHOL REVIEW
• 影响因子: 3.8
• 作者: Gunn, Rachel L.;Steingrimsson, Jon A.;Merrill, Jennifer E.;Souza, Timothy;Barnett, Nancy
• 通讯作者: Barnett, Nancy

Contingency management for alcohol use reduction: a pilot study using a transdermal alcohol sensor.

• DOI: 10.1016/j.drugalcdep.2011.04.023
• 发表时间: 2011-11-01
• 期刊: DRUG AND ALCOHOL DEPENDENCE
• 影响因子: 4.2
• 作者: Barnett, Nancy P.;Tidey, Jennifer;Murphy, James G.;Swift, Robert;Colby, Suzanne M.
• 通讯作者: Colby, Suzanne M.