IMPACT OF A SLEEP DEBT IN MID & OLDER AGED ADULTS

中期睡眠债的影响

• 批准号: 7604769
• 负责人: Eve Van Cauter
• 金额: $ 2.58万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7604769
• 关键词: Adult; Adverse effects; Affect; Age; Biological; Blood Pressure; Cardiac; Cardiovascular Physiology; Computer Retrieval of Information on Scientific Projects Database; Electroencephalography; End Point; Endocrine; Funding; Gender; Grant; Health; Heart Rate; Hormonal; Hunger; Hydrocortisone; Individual; Inflammatory; Institution; Intervention; Leptin; Measures; Metabolic; Monitor; Moods; Phase; Phase III Clinical Trials; Physiological; Predisposition; Recovery; Research; Research Personnel; Resources; Satiation; Sleep; Sleep Deprivation; Source; United States National Institutes of Health; Variant; Woman; Work; aged; cognitive function; design; electric impedance; glucose tolerance; impaired glucose tolerance; men' s group; middle age; neurobehavioral; neurobehavioral test; older men; young adult

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Previous work has demonstrated that sleep curtailment in young adults results in impaired glucose tolerance, elevated cortisol levels, reduced leptin levels, and increased cardiac sympathetic activity. In this study these same markers will be examined in young, middle-aged and older men and women before and after sleep interventions. This project is designed to determine whether: 1. sleep restriction has adverse effects on glucose tolerance, endocrine profiles, cardiovascular function and neurobehavioral 2. extending bedtimes (paying a sleep debt) will reverse the alterations seen after sleep restriction; 3. there is a relationship between individual sleep capacity and the impact of sleep restriction on health and neurobehavioral function; 4. the magnitude of sleep loss predicts the magnitude in the biological alterations explored in # 1; 5. individual variation in slow wave activity (SWA) predicts individual susceptibility to the adverse effects of sleep restriction; 6. there are age or gender related differences in the effects of sleep restriction. Metabolic and endocrine endpoints will include measures of glucose tolerance and 24h hormonal profiles. Pro-inflammatory markers known to be affected by sleep deprivation, blood pressure, heart rate variability and cardiac impedance, mood, cognitive function, hunger, satiety, and wake EEG will be monitored. Three groups of men and women age 18-25, 35-50 and 60-75 will undergo the following study phases; 3 nights with 8h bedtimes (baseline), 6 nights of 4h bedtimes (restriction), 7 nights of 12h bedtimes (recovery) and 6 nights of 10h bedtimes (capacity). Each phase will be followed by physiological and neurobehavioral testing.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 先前的工作表明，年轻人的睡眠减少会导致葡萄糖耐量受损，皮质醇水平升高，瘦素水平降低以及心脏交感神经活动增加。在这项研究中，将在睡眠干预前后的年轻，中年和老年男女中检查这些相同的标记。 该项目旨在确定是否： 1。睡眠限制对葡萄糖耐受性，内分泌特征，心血管功能和神经行为的不利影响 2。延长床位（支付睡眠债务）将扭转睡眠限制后看到的更改； 3。个人睡眠能力与睡眠限制对健康和神经行为功能的影响之间存在关系； 4。睡眠损失的幅度预测了＃1中探索的生物学变化的幅度； 5。慢波活动（SWA）的个体变化预测了对睡眠限制的不利影响的个人敏感性； 6。在睡眠限制的影响上存在年龄或性别相关的差异。 代谢和内分泌终点将包括葡萄糖耐受性和24H激素谱的度量。将监测已知的炎症标志物受到睡眠剥夺，血压，心率变异性和心脏阻抗，情绪，认知功能，饥饿，饱腹感和唤醒脑电图的影响。 18-25岁，35-50和60-75岁的男女将经历以下研究阶段； 3夜，有8h床的时间（基线），6夜床（限制）6晚，7晚12h床点（恢复）和6夜的10h床位（容量）。每个阶段将进行生理和神经行为测试。