IMPACT OF A SLEEP DEBT IN MID & OLDER AGED ADULTS

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Previous work has demonstrated that sleep curtailment in young adults results in impaired glucose tolerance, elevated cortisol levels, reduced leptin levels, and increased cardiac sympathetic activity. In this study these same markers will be examined in young, middle-aged and older men and women before and after sleep interventions. This project is designed to determine whether: 1. sleep restriction has adverse effects on glucose tolerance, endocrine profiles, cardiovascular function and neurobehavioral 2. extending bedtimes (paying a sleep debt) will reverse the alterations seen after sleep restriction; 3. there is a relationship between individual sleep capacity and the impact of sleep restriction on health and neurobehavioral function; 4. the magnitude of sleep loss predicts the magnitude in the biological alterations explored in # 1; 5. individual variation in slow wave activity (SWA) predicts individual susceptibility to the adverse effects of sleep restriction; 6. there are age or gender related differences in the effects of sleep restriction. Metabolic and endocrine endpoints will include measures of glucose tolerance and 24h hormonal profiles. Pro-inflammatory markers known to be affected by sleep deprivation, blood pressure, heart rate variability and cardiac impedance, mood, cognitive function, hunger, satiety, and wake EEG will be monitored. Three groups of men and women age 18-25, 35-50 and 60-75 will undergo the following study phases; 3 nights with 8h bedtimes (baseline), 6 nights of 4h bedtimes (restriction), 7 nights of 12h bedtimes (recovery) and 6 nights of 10h bedtimes (capacity). Each phase will be followed by physiological and neurobehavioral testing.