IMPACT OF A SLEEP DEBT IN MID & OLDER AGED ADULTS

中期睡眠债的影响

• 批准号: 7378639
• 负责人: Eve Van Cauter
• 金额: $ 16.2万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-18 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7378639
• 关键词: sleep

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Previous work has demonstrated that sleep curtailment in young adults results in impaired glucose tolerance, elevated cortisol levels, reduced leptin levels, and increased cardiac sympathetic activity. We will examine these same markers in the following ways: 1. Examining the impact of recurrent partial sleep loss in young, middle-aged and older adults. Sleep will be restricted to 4 hrs. 2. Testing whether extending bedtimes for sleep recovery will reverse the alterations resulting from sleep restriction. Sleep will be extended to 12 hours. 3. Examining age and gender related differences in the total amount of sleep recovery obtained during the week of 12-hour bedtimes. 4. Testing whether sleep capacity is partly determine by baseline levels of slow-wave sleep and slow-wave activity. 6. Examining whether sleep capacity is related to sleep need, by comparing the magnitude of changes to the magnitude of sleep debt.

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。先前的研究表明，年轻人睡眠减少会导致糖耐量受损，皮质醇水平升高，瘦素水平降低，心脏交感神经活动增加。我们将从以下几个方面检验这些指标：1.检验反复出现的部分睡眠不足对年轻人、中年人和老年人的影响。睡眠将被限制在4小时内。2.测试延长上床睡觉时间以恢复睡眠是否会逆转睡眠限制造成的变化。睡眠时间将延长至12小时。3.检查在12小时就寝时间的一周内获得的睡眠恢复总量在年龄和性别方面的差异。4.测试睡眠能力是否部分取决于慢波睡眠和慢波活动的基线水平。6.通过比较变化的幅度和睡眠负债的幅度，检查睡眠能力是否与睡眠需求有关。