EXTENDED WORK SCHEDULES AND HEALTH: ROLE OF SLEEP LOSS

延长工作时间与健康：睡眠不足的影响

• 批准号: 7604747
• 负责人: Eve Van Cauter
• 金额: $ 1.07万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7604747
• 关键词: Address; Age; Cardiovascular system; Catecholamines; Circadian Rhythms; Computer Retrieval of Information on Scientific Projects Database; Condition; Disruption; Endocrine; Epidemiologic Studies; Funding; Gender; Grant; Health; Hour; Hydrocortisone; Individual; Institution; Invasive; Mediating; Metabolic; Numbers; Outcome; Pathway interactions; Procedures; Protocols documentation; Recovery; Research; Research Personnel; Resources; Role; Rotation; Saliva; Schedule; Sleep; Source; Stress; Surveys; Testing; Time; United States National Institutes of Health; Urinary system; Work; carbohydrate metabolism; day; design; neurobehavioral; psychosocial; shift work; simulation

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Millions of individuals have extended work schedules and/or work schedules that result in circadian misalignment. Epidemiological studies and surveys indicate that such schedules nearly always result in restriction on the time allocated to sleep and that they are associated with adverse health outcomes. The mechanisms underlying the adverse health effects of these schedules are poorly understood and probably involve multiple psychosocial and pathophysiological pathways. This protocol addresses possible roles of sleep loss and circadian disruption in mediating some of the adverse health impact of shifted work schedules. The study is designed to test the hypotheses that 1. sleep loss as occurs during extended work schedules may result in adverse health consequences and that 2. circadian maladaptation, independently of sleep loss, has intrinsic adverse health consequences. Two groups of gender and age-matched healthy subjects age 21-39 will undergo either 1. simulation of extended activity without circadian disruption (night-time sleep of 5h) or 2. simulation of extended activities with rotations between daytime and nighttime activity (5h of daytime or nighttime sleep). The total number of bedtime hours is identical in both protocols. Metabolic, endocrine, cardiovascular and neurobehavioral functions are examined under baseline condition and at the end of 8 days of restricted bedtimes. An intermediate assessment using non-invasive procedures is conducted at the mid point of the period of sleep restriction. Assessments of stress-responsive systems (urinary catecholamines and saliva cortisol), carbohydrate metabolism and neurobehavioral function are also conducted after partial sleep recovery.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 数以百万计的人有延长的工作时间表和/或导致昼夜节律失调的工作时间表。流行病学研究和调查表明，这种时间表几乎总是导致分配给睡眠的时间受到限制，并与不利的健康后果有关。这些时间表对健康的不利影响的潜在机制尚不清楚，可能涉及多种心理社会和病理生理途径。该方案解决了睡眠不足和昼夜节律紊乱在调节改变工作时间对健康的一些不利影响方面可能起到的作用。这项研究旨在测试以下假设：1.在延长工作时间期间发生的睡眠不足可能会导致不利的健康后果，以及2.昼夜适应不良，与睡眠不足无关，具有内在的不利健康后果。 年龄21-39岁的两组年龄和性别匹配的健康受试者将接受以下两种实验：1.模拟无昼夜节律干扰的延长活动(夜间睡眠5小时)；2.模拟白天和夜间活动轮换的延长活动(白天或夜间睡眠5小时)。两种方案的总就寝时间是相同的。代谢、内分泌、心血管和神经行为功能在基线条件下和8天限制就寝结束时进行检查。使用非侵入性程序的中期评估是在睡眠限制的中点进行的。在部分睡眠恢复后，还进行压力反应系统(尿儿茶酚胺和唾液皮质醇)、碳水化合物代谢和神经行为功能的评估。