SLEEP LOSS AND CIRCADIAN DISRUPTION

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。长时间的工作几乎必然导致睡眠时间的减少。夜间工作者的睡眠时间最短。除了睡眠不足，倒班工作还会导致昼夜节律的慢性失调。本提案的总体目标是检验这样一种假设，即在长时间工作期间发生的睡眠不足可能会导致不利的健康后果，以及与睡眠不足无关的昼夜节律适应不良也会对健康产生负面影响。我们建议采用两种实验方案，包括8天的睡眠减少。第一个方案模拟了一个有规律的延长白天时间和限制夜间睡眠的时间表。第二个协议模拟了白天工作和夜间工作之间的工作时间表变化。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Extended work schedules almost invariably result in reduced time for sleep. Work schedules that produce the shortest sleep times are those of night workers. In addition to sleep loss, shift work also results in chronic maldaptation of circadian rhythms. The overall goal of the present proposal is to test the hypothesis that sleep loss occurs during extended work schedules may results in adverse health consequences and that circadian maladaptation, independently of sleep loss, has also negative health consequences. We propose to use two experimental protocol involving 8 days of bedtime curtailment. The first protocol simulates a schedule of regular extended daytime hours with restricted nighttime sleep. The second protocol simulates a work schedule altering between day work and night work.