SLEEP LOSS AND CIRCADIAN DISRUPTION

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Extended work schedules almost invariably result in reduced time for sleep. Work schedules that produce the shortest sleep times are those of night workers. In addition to sleep loss, shift work also results in chronic maldaptation of circadian rhythms. The overall goal of the present proposal is to test the hypothesis that sleep loss occurs during extended work schedules may results in adverse health consequences and that circadian maladaptation, independently of sleep loss, has also negative health consequences. We propose to use two experimental protocol involving 8 days of bedtime curtailment. The first protocol simulates a schedule of regular extended daytime hours with restricted nighttime sleep. The second protocol simulates a work schedule altering between day work and night work.